PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29877088-0 2018 Lauric Acid Accelerates Glycolytic Muscle Fiber Formation through TLR4 Signaling. lauric acid 0-11 toll like receptor 4 Homo sapiens 66-70 15843537-5 2005 The dominant negative mutant of TLR4 or its downstream signaling components inhibits lauric acid-induced expression of a CD86 promoter-reporter gene. lauric acid 85-96 toll like receptor 4 Homo sapiens 32-36 19648648-4 2009 Here, we report for the first time that the saturated fatty acid lauric acid induced dimerization and recruitment of TLR4 into lipid rafts, however, dimerization was not observed in non-lipid raft fractions. lauric acid 65-76 toll like receptor 4 Homo sapiens 117-121 19648648-5 2009 Similarly, LPS and lauric acid enhanced the association of TLR4 with MD-2 and downstream adaptor molecules, TRIF and MyD88, into lipid rafts leading to the activation of downstream signaling pathways and target gene expression. lauric acid 19-30 toll like receptor 4 Homo sapiens 59-63 19648648-6 2009 However, docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, inhibited LPS- or lauric acid-induced dimerization and recruitment of TLR4 into lipid raft fractions. lauric acid 90-101 toll like receptor 4 Homo sapiens 142-146 19648648-7 2009 Together, these results demonstrate that lauric acid and DHA reciprocally modulate TLR4 activation by regulation of the dimerization and recruitment of TLR4 into lipid rafts. lauric acid 41-52 toll like receptor 4 Homo sapiens 83-87 19648648-7 2009 Together, these results demonstrate that lauric acid and DHA reciprocally modulate TLR4 activation by regulation of the dimerization and recruitment of TLR4 into lipid rafts. lauric acid 41-52 toll like receptor 4 Homo sapiens 152-156 12865424-4 2003 Saturated fatty acid (lauric acid)-induced NFkappaB activation was inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6, or IkappaBalpha in macrophages (RAW264.7) and 293T cells transfected with TLR4 and MD2. lauric acid 22-33 toll like receptor 4 Homo sapiens 212-216 12865424-9 2003 These results demonstrate that NFkappaB activation and COX-2 expression induced by lauric acid are at least partly mediated through the TLR4/PI3K/AKT signaling pathway. lauric acid 83-94 toll like receptor 4 Homo sapiens 136-140