PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29877088-0	2018	Lauric Acid Accelerates Glycolytic Muscle Fiber Formation through TLR4 Signaling.	lauric acid	0-11	toll like receptor 4	Homo sapiens	66-70	
15843537-5	2005	The dominant negative mutant of TLR4 or its downstream signaling components inhibits lauric acid-induced expression of a CD86 promoter-reporter gene.	lauric acid	85-96	toll like receptor 4	Homo sapiens	32-36	
19648648-4	2009	Here, we report for the first time that the saturated fatty acid lauric acid induced dimerization and recruitment of TLR4 into lipid rafts, however, dimerization was not observed in non-lipid raft fractions.	lauric acid	65-76	toll like receptor 4	Homo sapiens	117-121	
19648648-5	2009	Similarly, LPS and lauric acid enhanced the association of TLR4 with MD-2 and downstream adaptor molecules, TRIF and MyD88, into lipid rafts leading to the activation of downstream signaling pathways and target gene expression.	lauric acid	19-30	toll like receptor 4	Homo sapiens	59-63	
19648648-6	2009	However, docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, inhibited LPS- or lauric acid-induced dimerization and recruitment of TLR4 into lipid raft fractions.	lauric acid	90-101	toll like receptor 4	Homo sapiens	142-146	
19648648-7	2009	Together, these results demonstrate that lauric acid and DHA reciprocally modulate TLR4 activation by regulation of the dimerization and recruitment of TLR4 into lipid rafts.	lauric acid	41-52	toll like receptor 4	Homo sapiens	83-87	
19648648-7	2009	Together, these results demonstrate that lauric acid and DHA reciprocally modulate TLR4 activation by regulation of the dimerization and recruitment of TLR4 into lipid rafts.	lauric acid	41-52	toll like receptor 4	Homo sapiens	152-156	
12865424-4	2003	Saturated fatty acid (lauric acid)-induced NFkappaB activation was inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6, or IkappaBalpha in macrophages (RAW264.7) and 293T cells transfected with TLR4 and MD2.	lauric acid	22-33	toll like receptor 4	Homo sapiens	212-216	
12865424-9	2003	These results demonstrate that NFkappaB activation and COX-2 expression induced by lauric acid are at least partly mediated through the TLR4/PI3K/AKT signaling pathway.	lauric acid	83-94	toll like receptor 4	Homo sapiens	136-140