PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10453996-5	1999	Cytochrome P450 4A1 modulates the cellular level of lauric acid, an inhibitor of phospholipid synthesis.	lauric acid	52-63	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	0-19	
10620324-7	2000	The highest activity for lauric acid was obtained with CYP4A1 and CYP4A8, but for all the proteins the activity decreased with increasing fatty acid chain length.	lauric acid	25-36	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	55-61	
9581653-10	1998	Immunoinhibitions specific to CYP2E1 significantly decreased the (omega-1)-hydroxylation of lauric acid in liver, but not in kidney microsomes, whereas the polyclonal anti-CYP4A1 antibody inhibited omega- and (omega-1)-hydroxylations of lauric acid in kidney microsomes.	lauric acid	92-103	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	172-178	
9738460-8	1998	The stimulatory effect of CLA administration on the efficiency of the ethanolamine-specific PLBE reaction can be explained by elimination of lauric acid, a known inhibitor of de novo PE synthesis, during the course of omega-hydroxylation catalysed by CYP4A1, and by increased expression of the PLBE enzyme.	lauric acid	141-152	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	251-257	
9581653-10	1998	Immunoinhibitions specific to CYP2E1 significantly decreased the (omega-1)-hydroxylation of lauric acid in liver, but not in kidney microsomes, whereas the polyclonal anti-CYP4A1 antibody inhibited omega- and (omega-1)-hydroxylations of lauric acid in kidney microsomes.	lauric acid	237-248	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	172-178	
9701504-2	1998	This was accompanied by 3.4-fold activation of microsomal omega-hydroxylation of lauric acid by cytochrome P450 4A1 isoform (CYP4A1) and an increase in the protein content of this isoform in endoplasmic reticulum (ER) membranes.	lauric acid	81-92	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	96-115	
9701504-2	1998	This was accompanied by 3.4-fold activation of microsomal omega-hydroxylation of lauric acid by cytochrome P450 4A1 isoform (CYP4A1) and an increase in the protein content of this isoform in endoplasmic reticulum (ER) membranes.	lauric acid	81-92	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	125-131	
8837739-2	1996	To elucidate the chemical basis of this specificity we probed the active site of a CYP4A1 fusion protein (f4A1) with bulky and/ or rigid analogs of lauric acid, the optimum natural substrate for f4A1 and CYP4A1.	lauric acid	148-159	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	83-89	
8529824-9	1995	Cytochrome P450 4A1 increased in both species at doses of 25 mg/kg or greater and correlated with increased lauric acid hydroxylation.	lauric acid	108-119	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	0-19	
3929789-0	1985	Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 to the metabolism of lauric acid and arachidonic acid.	lauric acid	105-116	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	67-83	
7872779-0	1995	Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein.	lauric acid	32-43	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	69-75	
7872779-1	1995	The binding and hydroxylation of lauric acid by a genetically engineered and expressed fusion protein comprised of an N-truncated form of rat CYP4A1 linked to an N-truncated form of rat NADPH cytochrome P450 oxidoreductase (OR) (constructed by Fisher et al., (1992) Proc.	lauric acid	33-44	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	142-148	
7872779-8	1995	(omega-1)-Hydroxylation of lauric acid was barely detectable (omega/(omega-1) = 135) with f4A1 or with reconstituted CYP4A1, but it accounted for up to 50% of total products formed by microsomes from clofibrate-induced rats.	lauric acid	27-38	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	117-123	
1662512-6	1991	This was confirmed by the observations that (1) lauric acid hydroxylation was inhibited by 0.02% Tween 20 or Tween 80 and 25 microM capric or myristic acids, whereas omega-MMEN hydroxylation was not, (2) omega-MMEN hydroxylation was inhibited by ketoconazole, cholesterol and acetone, whereas lauric acid hydroxylation was not, and (3) CYP4A1 and CYP4A3 expressed in Hep G2 cells did not catalyze MMEN hydroxylation.	lauric acid	48-59	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	336-342	
8216351-3	1993	Consistent with these conclusions, both trimer and tetramer increased the hydroxylation of lauric acid indicating that the CTFEs were inducers of the CYP4A subfamily, a conclusion further supported by substantial increases in the steady-state levels of the cognate CYP4A1 mRNA as determined by northern blotting.	lauric acid	91-102	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	265-271	
2776771-3	1989	There was a marked compound dependence on induction of both cytochrome P-450-IVA1-dependent omega-hydroxylation of lauric acid and enzymes of the peroxisomal fatty acid beta-oxidation pathway (measured as cyanide-insensitive palmitoyl-CoA oxidation and enoyl-CoA hydratase).	lauric acid	115-126	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	60-81	
2776771-4	1989	Cytochrome P-450 IVA1 (or a very closely related isoenzyme in the same gene family) was a major constitutive haemoprotein in rat kidney microsomes and actively supported the omega-hydroxylation of lauric acid.	lauric acid	197-208	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	0-21	
2776771-6	1989	By using a cDNA probe to the cytochrome P-450 IVA1 gene in Northern blot analysis, we have shown that increased renal and hepatic omega-hydroxylation of lauric acid, after treatment with peroxisome proliferators is a consequences of a substantial increase in the mRNA coding for this haemoprotein.	lauric acid	153-164	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	29-50	
3365259-2	1988	In this study, it has been observed that the nodules show a large decrease in an additional cytochrome P-450, cytochrome P-452, which is very active in the hydroxylation of lauric acid at C-11 and C-12.	lauric acid	173-184	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	110-126	
3931693-10	1985	A close linkage was established between bilirubin UDPglucuronosyltransferase induction and that of cytochrome P-452, as shown by enhanced omega-oxidation of lauric acid.	lauric acid	157-168	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	99-115	
3929789-2	1985	All of the hypolipidaemic drugs tested significantly induced the hydroxylation of lauric acid and, furthermore, this was accompanied by a concomitant 3-fold induction of a specific isoenzyme of cytochrome P-450 (termed cytochrome P-452) as determined by a single radial immunodiffusion technique.	lauric acid	82-93	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	219-235	
3929789-5	1985	Cytochrome P-452 plays a significant role in the hydroxylation of lauric acid as evidenced by inhibition of hydroxylase activity in the presence of an anti-P-452 IgG fraction.	lauric acid	66-77	cytochrome P450, family 4, subfamily a, polypeptide 1	Rattus norvegicus	0-16