PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34122599-5 2021 Cinobufotalin combined with gefitinib induced a significant enhancement in reactive oxygen species (ROS) production accompanied by cell cycle arrest in the S phase arrest, characterized by upregulation of p21 and downregulation of cyclin A, cyclin E, and CDK2. cinobufotalin 0-13 cyclin dependent kinase inhibitor 1A Homo sapiens 205-208