PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31645369-6	2019	We were able to demonstrate not only an accumulation of different forms of mutant huntingtin (mHTT) in TgHD brain, but also pathological changes associated with cellular damage caused by mHTT.	mhtt	94-98	huntingtin	Homo sapiens	82-92	
32796930-7	2020	Therapeutically, the first human trial of an HTT-lowering antisense oligonucleotide successfully, and safely, reduced the CSF concentration of mHTT in individuals with HD.	mhtt	143-147	huntingtin	Homo sapiens	45-48	
33310753-11	2021	Recently, it was demonstrated that intrathecal administration of a HTT lowering agent leads to dose-dependent reduction of CSF mHTT in HD patients.	mhtt	127-131	huntingtin	Homo sapiens	67-70	
33310753-13	2021	Our findings that HTT enters CSF by both passive release and active secretion followed by glymphatic clearance may have significant implications for interpretation of treatment-induced changes of CSF mHTT in clinical trials for HD.	mhtt	200-204	huntingtin	Homo sapiens	18-21	
32439599-6	2020	Despite the small degree of spreading, the presence of mHTT generated changes in endogenous huntingtin (HTT) levels in both models.	mhtt	55-59	huntingtin	Homo sapiens	92-102	
17034350-5	2006	Mutant htt-mediated toxicity in the brain disrupts a number of vital cellular processes in the course of disease progression, including energy metabolism, gene transcription, clathrin-dependent endocytosis, intraneuronal trafficking, and postsynaptic signaling, but the crucial initiation mechanism induced by mhtt is still unclear.	mhtt	310-314	huntingtin	Homo sapiens	7-10	
29362455-3	2018	In this study, we examine recruitment of ubiquitin to IBs of polyglutamine-expanded huntingtin fragments (mHtt) by using synthesized TAMRA-labeled ubiquitin moieties.	mhtt	106-110	huntingtin	Homo sapiens	84-94	
30452421-6	2018	Improving understanding of HTT expression and control may also uncover novel therapeutic approaches for HD through the development of methods to modulate mHTT levels.	mhtt	154-158	huntingtin	Homo sapiens	27-30	
22123826-12	2012	Our data suggest that Htt is an Hsp90 client protein and that Hsp90 inhibition may provide a means to reduce mHtt in HD.	mhtt	109-113	huntingtin	Homo sapiens	22-25	
15340079-6	2004	Consistent with a progressive loss of function, wild-type htt, trafficking motors, and mitochondrial components were selectively sequestered by mhtt in human Huntington"s disease-affected brain.	mhtt	144-148	huntingtin	Homo sapiens	58-61