PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12538606-6 2003 Western immunoblot analysis demonstrated that TCDD treatment of hLGC decreased the expression of P450c17 by as much 50% (P < 0.05). Polychlorinated Dibenzodioxins 46-50 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-104 12538606-9 2003 We conclude that the molecular target for endocrine disruption of hLGC by TCDD is P450c17, specifically decreasing the supply of androgens for E2 synthesis, and that it does not involve either P450arom or the redox partner protein reductase. Polychlorinated Dibenzodioxins 74-78 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 82-89 12493720-5 2003 The objective of the experiment was to test the hypothesis that exogenous steroid, substrate for P450(c17), would reduce the TCDD effects on E(2) synthesis. Polychlorinated Dibenzodioxins 125-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 97-105 12493720-12 2003 Thus, these data suggest that the most likely target for the TCDD-induced inhibition of estrogen synthesis by hLGC is the 17,20-lyase activity of the P450(c17) enzyme complex. Polychlorinated Dibenzodioxins 61-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 150-158