PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12538606-6	2003	Western immunoblot analysis demonstrated that TCDD treatment of hLGC decreased the expression of P450c17 by as much 50% (P < 0.05).	Polychlorinated Dibenzodioxins	46-50	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	97-104	
12538606-9	2003	We conclude that the molecular target for endocrine disruption of hLGC by TCDD is P450c17, specifically decreasing the supply of androgens for E2 synthesis, and that it does not involve either P450arom or the redox partner protein reductase.	Polychlorinated Dibenzodioxins	74-78	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	82-89	
12493720-5	2003	The objective of the experiment was to test the hypothesis that exogenous steroid, substrate for P450(c17), would reduce the TCDD effects on E(2) synthesis.	Polychlorinated Dibenzodioxins	125-129	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	97-105	
12493720-12	2003	Thus, these data suggest that the most likely target for the TCDD-induced inhibition of estrogen synthesis by hLGC is the 17,20-lyase activity of the P450(c17) enzyme complex.	Polychlorinated Dibenzodioxins	61-65	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	150-158