PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9605431-3 1998 Doses of 2 and 10 microg TCDD/kg decreased adipose tissue epidermal growth factor receptor (EGFR) binding activity 5 and 7 days later in immature and mature females, respectively. Polychlorinated Dibenzodioxins 25-29 epidermal growth factor receptor Rattus norvegicus 58-90 11752688-8 2002 TCDD induced alterations within the developing reproductive tract in the subcellular and temporal expression of transforming growth factor-beta3 (TGF-beta3) and epidermal growth factor receptor (EGFR). Polychlorinated Dibenzodioxins 0-4 epidermal growth factor receptor Rattus norvegicus 161-193 11752688-8 2002 TCDD induced alterations within the developing reproductive tract in the subcellular and temporal expression of transforming growth factor-beta3 (TGF-beta3) and epidermal growth factor receptor (EGFR). Polychlorinated Dibenzodioxins 0-4 epidermal growth factor receptor Rattus norvegicus 195-199 9653074-0 1998 Treatment of rats during pubertal development with 2,3,7,8-tetrachlorodibenzo-p-dioxin alters both signaling kinase activities and epidermal growth factor receptor binding in the testis and the motility and acrosomal reaction of sperm. Polychlorinated Dibenzodioxins 51-86 epidermal growth factor receptor Rattus norvegicus 131-163 9653074-15 1998 These findings provide evidence for involvement of Src kinase signaling and EGFR in the mechanism by which TCDD disrupts testicular development and subsequently affects testis function. Polychlorinated Dibenzodioxins 107-111 epidermal growth factor receptor Rattus norvegicus 76-80 9605431-3 1998 Doses of 2 and 10 microg TCDD/kg decreased adipose tissue epidermal growth factor receptor (EGFR) binding activity 5 and 7 days later in immature and mature females, respectively. Polychlorinated Dibenzodioxins 25-29 epidermal growth factor receptor Rattus norvegicus 92-96 9605431-11 1998 Geldanamycin antagonized the effects of TCDD on EGFR binding activity and TK activity. Polychlorinated Dibenzodioxins 40-44 epidermal growth factor receptor Rattus norvegicus 48-52 1313194-4 1992 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), which exhibits a broad spectrum of antiestrogenic effects in the female rat uterus, inhibited the 17 beta-estradiol-induced increase in uterine wet weights, cytosolic and nuclear ER and PR levels, peroxidase activity, and EGF receptor binding activity. Polychlorinated Dibenzodioxins 0-35 epidermal growth factor receptor Rattus norvegicus 266-278 21781670-1 1996 Epidermal growth factor (EGF) receptor has been implied as having a role in certain actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 95-130 epidermal growth factor receptor Rattus norvegicus 0-38 21781670-1 1996 Epidermal growth factor (EGF) receptor has been implied as having a role in certain actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins 132-136 epidermal growth factor receptor Rattus norvegicus 0-38 21781670-5 1996 In the TCDD-sensitive L-E strain both the B(max) of the EGF receptor and the receptor protein as measured by Western blots, decreased dose and time dependently. Polychlorinated Dibenzodioxins 7-11 epidermal growth factor receptor Rattus norvegicus 56-68 21781670-11 1996 The results demonstrate that downregulation of the EGF receptor by TCDD is strain-dependent as well as dose- and time-dependent. Polychlorinated Dibenzodioxins 67-71 epidermal growth factor receptor Rattus norvegicus 51-63 7482548-4 1995 It suggests that TCDD-stimulated production of a peptide ligand of the epidermal growth factor (EGF) receptor and subsequent activation of the receptor"s tyrosine kinase activity may increase the rate of proliferation of susceptible cells. Polychlorinated Dibenzodioxins 17-21 epidermal growth factor receptor Rattus norvegicus 71-109 8403215-0 1993 TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD. Polychlorinated Dibenzodioxins 0-4 epidermal growth factor receptor Rattus norvegicus 33-65 8403215-0 1993 TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD. Polychlorinated Dibenzodioxins 126-130 epidermal growth factor receptor Rattus norvegicus 33-65 8403215-11 1993 These results demonstrate that the observed down modulation of the EGFR by TCDD is ovarian-dependent and is a sensitive effect induced at dose levels associated with TCDD hepatocarcinogenicity in rodent bioassays. Polychlorinated Dibenzodioxins 75-79 epidermal growth factor receptor Rattus norvegicus 67-71 7785053-0 1995 TCDD reduces rat hepatic epidermal growth factor receptor: comparison of binding, immunodetection, and autophosphorylation. Polychlorinated Dibenzodioxins 0-4 epidermal growth factor receptor Rattus norvegicus 25-57 7785053-1 1995 Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent tumor promoter, to rats resulted in a dose-dependent decrease in hepatic plasma membrane epidermal growth factor receptor (EGFR). Polychlorinated Dibenzodioxins 18-53 epidermal growth factor receptor Rattus norvegicus 160-192 7785053-1 1995 Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent tumor promoter, to rats resulted in a dose-dependent decrease in hepatic plasma membrane epidermal growth factor receptor (EGFR). Polychlorinated Dibenzodioxins 18-53 epidermal growth factor receptor Rattus norvegicus 194-198 7785053-1 1995 Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent tumor promoter, to rats resulted in a dose-dependent decrease in hepatic plasma membrane epidermal growth factor receptor (EGFR). Polychlorinated Dibenzodioxins 55-59 epidermal growth factor receptor Rattus norvegicus 160-192 7785053-1 1995 Administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent tumor promoter, to rats resulted in a dose-dependent decrease in hepatic plasma membrane epidermal growth factor receptor (EGFR). Polychlorinated Dibenzodioxins 55-59 epidermal growth factor receptor Rattus norvegicus 194-198 7785053-3 1995 All three methods similarly demonstrated that the level of hepatic EGFR is significantly decreased at a dose of TCDD as low as 1 micrograms/kg. Polychlorinated Dibenzodioxins 112-116 epidermal growth factor receptor Rattus norvegicus 67-71 7785053-5 1995 It is concluded that TCDD decreased total EGFR protein and maximum binding capacity without altering ligand binding affinity (Kd). Polychlorinated Dibenzodioxins 21-25 epidermal growth factor receptor Rattus norvegicus 42-46 1313194-4 1992 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), which exhibits a broad spectrum of antiestrogenic effects in the female rat uterus, inhibited the 17 beta-estradiol-induced increase in uterine wet weights, cytosolic and nuclear ER and PR levels, peroxidase activity, and EGF receptor binding activity. Polychlorinated Dibenzodioxins 37-41 epidermal growth factor receptor Rattus norvegicus 266-278 2289633-0 1990 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression. Polychlorinated Dibenzodioxins 0-35 epidermal growth factor receptor Rattus norvegicus 101-133 2289633-3 1990 In contrast, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused a dose-response decrease in constitutive rat uterine EGF receptor binding activity and this was paralleled by a decrease in steady-state levels of uterine EGF receptor mRNA. Polychlorinated Dibenzodioxins 13-48 epidermal growth factor receptor Rattus norvegicus 116-128 2289633-3 1990 In contrast, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused a dose-response decrease in constitutive rat uterine EGF receptor binding activity and this was paralleled by a decrease in steady-state levels of uterine EGF receptor mRNA. Polychlorinated Dibenzodioxins 13-48 epidermal growth factor receptor Rattus norvegicus 218-230 2289633-3 1990 In contrast, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused a dose-response decrease in constitutive rat uterine EGF receptor binding activity and this was paralleled by a decrease in steady-state levels of uterine EGF receptor mRNA. Polychlorinated Dibenzodioxins 50-54 epidermal growth factor receptor Rattus norvegicus 116-128 2289633-3 1990 In contrast, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) caused a dose-response decrease in constitutive rat uterine EGF receptor binding activity and this was paralleled by a decrease in steady-state levels of uterine EGF receptor mRNA. Polychlorinated Dibenzodioxins 50-54 epidermal growth factor receptor Rattus norvegicus 218-230 2289633-4 1990 Cotreatment of the animals with both TCDD (16 nmol/kg) and 17 beta-estradiol (5 micrograms/rat) gave results which showed that TCDD significantly inhibited the estrogen-induced increases in rat uterine EGF receptor binding activity and EGF receptor mRNA levels. Polychlorinated Dibenzodioxins 127-131 epidermal growth factor receptor Rattus norvegicus 202-214 2289633-4 1990 Cotreatment of the animals with both TCDD (16 nmol/kg) and 17 beta-estradiol (5 micrograms/rat) gave results which showed that TCDD significantly inhibited the estrogen-induced increases in rat uterine EGF receptor binding activity and EGF receptor mRNA levels. Polychlorinated Dibenzodioxins 127-131 epidermal growth factor receptor Rattus norvegicus 236-248 3600186-3 1987 The TCDD-evoked rise in such protein tyrosine kinase activity precedes the down-regulation of the EGF (epidermal growth factor) receptor in the plasma membrane in vivo. Polychlorinated Dibenzodioxins 4-8 epidermal growth factor receptor Rattus norvegicus 103-136 2718174-4 1989 Recent studies have shown that TCDD modifies the equilibrium binding kinetics of the rat liver cytosolic glucocorticoid receptor (GRc) and the hepatic plasma membrane epidermal growth factor (EGF) receptor. Polychlorinated Dibenzodioxins 31-35 epidermal growth factor receptor Rattus norvegicus 167-205 3266253-0 1988 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an increase in protein kinases associated with epidermal growth factor receptor in the hepatic plasma membrane. Polychlorinated Dibenzodioxins 0-35 epidermal growth factor receptor Rattus norvegicus 90-122 3266253-1 1988 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), administered to male rats at a single intraperitoneal (IP) injection dose of 25 micrograms/kg causes down-regulation of epidermal growth factor (EGF) receptor in the plasma membrane of rat liver which starts after two days and continues throughout the experimental period (20 days). Polychlorinated Dibenzodioxins 0-35 epidermal growth factor receptor Rattus norvegicus 164-202 3266253-1 1988 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), administered to male rats at a single intraperitoneal (IP) injection dose of 25 micrograms/kg causes down-regulation of epidermal growth factor (EGF) receptor in the plasma membrane of rat liver which starts after two days and continues throughout the experimental period (20 days). Polychlorinated Dibenzodioxins 37-41 epidermal growth factor receptor Rattus norvegicus 164-202 15592923-5 2005 Because TCDD leads to phosphorylation of the epidermal growth factor receptor and an increase in c-Src-activation in WB-F344 cells, we investigated the functional relevance of this observation. Polychlorinated Dibenzodioxins 8-12 epidermal growth factor receptor Rattus norvegicus 45-77 6095293-1 1984 The effect of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF) receptor activity of the rat hepatic plasma membrane was studied. Polychlorinated Dibenzodioxins 35-70 epidermal growth factor receptor Rattus norvegicus 81-119 6095293-1 1984 The effect of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF) receptor activity of the rat hepatic plasma membrane was studied. Polychlorinated Dibenzodioxins 72-76 epidermal growth factor receptor Rattus norvegicus 81-119 6095293-11 1984 TCDD was also found to stimulate phosphorylation of the EGF receptor in the rat hepatic plasma membrane. Polychlorinated Dibenzodioxins 0-4 epidermal growth factor receptor Rattus norvegicus 56-68 6095293-14 1984 Accordingly, a hypothesis has been proposed to ascribe some of the EGF-like effects of TCDD, such as fatty infiltration of the liver and hyperplastic proliferation of gastric epithelia and epidermal cells to its action on the EGF receptor. Polychlorinated Dibenzodioxins 87-91 epidermal growth factor receptor Rattus norvegicus 226-238