PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9705214-9	1998	For example, TCDD significantly inhibited E2-induced hyperphosphorylation of RB, cyclin D1 protein, and cdk2-, cdk4-, and cdk7-dependent kinase activities.	Polychlorinated Dibenzodioxins	13-17	cyclin D1	Homo sapiens	81-90	
15322241-4	2004	p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD.	Polychlorinated Dibenzodioxins	124-128	cyclin D1	Homo sapiens	53-88	
15322241-4	2004	p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD.	Polychlorinated Dibenzodioxins	254-258	cyclin D1	Homo sapiens	53-88	
9705214-10	1998	Inhibition of E2-induced cdk4-dependent kinase activity by TCDD may be related to the parallel decrease of E2-induced cyclin D1 protein, and inhibition of induced cdk2- and cdk4-dependent kinase activities may be due to significantly increased p21 levels in cells cotreated with TCDD plus E2.	Polychlorinated Dibenzodioxins	59-63	cyclin D1	Homo sapiens	118-127	
31217064-0	2019	2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway.	Polychlorinated Dibenzodioxins	0-35	cyclin D1	Homo sapiens	96-105	
31217064-7	2019	The exposure to TCDD resulted in the upregulation in the expression levels of phosphorylated protein kinase B (p-Akt), phosphorylated STAT3, and cyclin D1 in a dose- and time-dependent manner.	Polychlorinated Dibenzodioxins	16-20	cyclin D1	Homo sapiens	145-154	
31217064-8	2019	The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation.	Polychlorinated Dibenzodioxins	92-96	cyclin D1	Homo sapiens	105-114	
31217064-11	2019	CONCLUSION: TCDD exposure promotes the proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway, leading to astrogliosis.	Polychlorinated Dibenzodioxins	12-16	cyclin D1	Homo sapiens	90-99	
28103884-11	2017	Mechanistically, Induction of AhR/CYP1A1 by TCDD and DMBA was associated with significant increase in beta-Catenin mRNA and protein expression, nuclear translocation and its downstream target Cyclin D1, whereas AhR or CYP1A1 knockdown using shRNA dramatically inhibited beta-Catenin cellular content and nuclear translocation.	Polychlorinated Dibenzodioxins	44-48	cyclin D1	Homo sapiens	192-201	
27312872-6	2016	The protein level assays revealed that TCDD increased cyclin-dependent kinases 4 (cdk4), cyclin D1, cyclin E and p21 (Waf1/Cip1) but not cdk2, bcl-2, cyclin B1 and cyclin A.	Polychlorinated Dibenzodioxins	39-43	cyclin D1	Homo sapiens	89-98	
19917880-9	2010	In vitro assays for CDK4 kinase activity demonstrated that RB1 phosphorylation by the AHR/CDK4/CCND1 complex was reduced in the presence of TCDD.	Polychlorinated Dibenzodioxins	140-144	cyclin D1	Homo sapiens	95-100