PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31083300-2 2019 Tiparp-/- mice exhibit increased sensitivity to the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including lethal wasting syndrome. Polychlorinated Dibenzodioxins 77-112 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 0-6 31083300-2 2019 Tiparp-/- mice exhibit increased sensitivity to the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including lethal wasting syndrome. Polychlorinated Dibenzodioxins 114-118 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 0-6 23508103-6 2013 Activation of AhR induced tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP) gene expression, depleted NAD(+), deactivated the mitochondrial sirtuin deacetylase 3 (Sirt3), increased SOD2 acetylation, and thereby decreased SOD2 activity. Polychlorinated Dibenzodioxins 26-53 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 100-106 29873790-3 2018 We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. Polychlorinated Dibenzodioxins 36-40 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 104-110 29873790-3 2018 We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. Polychlorinated Dibenzodioxins 36-40 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 111-116 29873790-3 2018 We previously reported that loss of TCDD-inducible poly(adenosine diphosphate [ADP]-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. Polychlorinated Dibenzodioxins 36-40 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 117-123 26814197-3 2016 In the present study, we report that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP), mono-ADP-ribosylates and positively regulates liver X receptor alpha (LXRalpha) and LXRbeta activity. Polychlorinated Dibenzodioxins 37-72 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 118-124 26814197-3 2016 In the present study, we report that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP), mono-ADP-ribosylates and positively regulates liver X receptor alpha (LXRalpha) and LXRbeta activity. Polychlorinated Dibenzodioxins 74-78 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 118-124 23508103-6 2013 Activation of AhR induced tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP) gene expression, depleted NAD(+), deactivated the mitochondrial sirtuin deacetylase 3 (Sirt3), increased SOD2 acetylation, and thereby decreased SOD2 activity. Polychlorinated Dibenzodioxins 55-59 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 100-106 23275542-9 2013 TCDD-dependent induction of AHR target genes was enhanced in Tiparp(-/-) mouse embryonic fibroblasts compared with wildtype controls. Polychlorinated Dibenzodioxins 0-4 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 61-67 12147270-1 2002 The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a novel poly(ADP-ribose) polymerase (TiPARP). Polychlorinated Dibenzodioxins 30-65 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 118-124 12147270-1 2002 The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a novel poly(ADP-ribose) polymerase (TiPARP). Polychlorinated Dibenzodioxins 67-71 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 118-124 12147270-3 2002 Induction of TiPARP by TCDD occurs in both hepa1c1c7 cells and C57 mouse liver. Polychlorinated Dibenzodioxins 23-27 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 13-19 12147270-10 2002 These findings establish that induction of TiPARP by TCDD is mediated through an AhR and Arnt transcription activation-dependent signal transduction that is repressed by a labile factor through the ubiquitin-26S proteasome-mediated protein degradation. Polychlorinated Dibenzodioxins 53-57 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 43-49 34146543-8 2021 This study reveals a novel function of TiPARP in controlling TCDD-activated AHR nuclear export and subsequent proteasomal degradation. Polychlorinated Dibenzodioxins 61-65 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 39-45 34129049-0 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. Polychlorinated Dibenzodioxins 0-35 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 81-87 34129049-0 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. Polychlorinated Dibenzodioxins 0-35 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 88-93 34129049-0 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. Polychlorinated Dibenzodioxins 37-41 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 81-87 34129049-0 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. Polychlorinated Dibenzodioxins 37-41 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 88-93 34129049-0 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. Polychlorinated Dibenzodioxins 164-168 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 81-87 34129049-0 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality. Polychlorinated Dibenzodioxins 164-168 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 88-93 34129049-1 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. Polychlorinated Dibenzodioxins 0-35 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 81-87 34129049-1 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. Polychlorinated Dibenzodioxins 0-35 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 88-93 34129049-1 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. Polychlorinated Dibenzodioxins 37-41 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 81-87 34129049-1 2021 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. Polychlorinated Dibenzodioxins 37-41 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 88-93 34129049-3 2021 We hypothesized that the loss of TIPARP catalytic activity would increase sensitivity to TCDD-induced toxicity in vivo. Polychlorinated Dibenzodioxins 89-93 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 33-39 34129049-5 2021 Treatment of mouse embryonic fibroblasts or hepatocytes isolated from TiparpH532A mice confirmed the increased TCDD-induced expression of the AHR target genes Cyp1a1, Cyp1b1 and Tiparp. Polychlorinated Dibenzodioxins 111-115 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 178-184 34129049-11 2021 Taken together, these data further support TIPARP as a critical negative regulator of AHR activity and show that loss of its catalytic activity is sufficient to increase sensitivity to TCDD-induced steatohepatitis and lethality. Polychlorinated Dibenzodioxins 185-189 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 43-49 34146543-0 2021 Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR. Polychlorinated Dibenzodioxins 73-77 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 63-69 35055106-0 2022 Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice. Polychlorinated Dibenzodioxins 34-69 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 98-104 35055106-0 2022 Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice. Polychlorinated Dibenzodioxins 34-69 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 105-110