PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1905127-11 1991 The development of the IL-2-marker in culture was only slightly affected by TCDD, and concentrations of 1 x 10(-12) M were required to slightly reduce the number of CD2+CD25+ cells. Polychlorinated Dibenzodioxins 76-80 interleukin 2 Homo sapiens 23-27 16696175-0 2004 Coumestrol, bisphenol-A, DDT, and TCDD modulation of interleukin-2 expression in activated CD+4 Jurkat T cells. Polychlorinated Dibenzodioxins 34-38 interleukin 2 Homo sapiens 53-66 16696175-7 2004 Coumestrol, DDT and TCDD (but not BPA) significantly suppressed IL-2 production in activated CD4+ Jurkat T cells, at the transcriptional and translational levels. Polychlorinated Dibenzodioxins 20-24 interleukin 2 Homo sapiens 64-68 16696175-9 2004 Although the direct mechanisms of xenoestrogens modulation of the immune system remain to be elucidated, coumestrol-, DDT- and TCDD-induced suppression of IL-2 may have ramifications for our understanding of the impact of xenoestrogens on health and disease. Polychlorinated Dibenzodioxins 127-131 interleukin 2 Homo sapiens 155-159 8732953-7 1996 No significant differences could be detected between the individuals tested and controls for surface marker distribution or mitogen-induced lymphoproliferation TCDD-exposed subjects showed a reduced response to human lymphocyte antigen-allogeneic lymphocytes and interleukin-2-boosted proliferation. Polychlorinated Dibenzodioxins 160-164 interleukin 2 Homo sapiens 263-276 8732953-9 1996 Furthermore, the capacity of a pool of T cells isolated from TCDD-exposed subjects to proliferate upon interleukin-2 stimulation was significantly diminished (p < or = 0.05). Polychlorinated Dibenzodioxins 61-65 interleukin 2 Homo sapiens 103-116