PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20570689-9	2010	Although FMO3 mRNA is highly induced by 3MC or TCDD in mouse liver and in Hepa-1 cells, FMO protein levels and FMO catalytic function showed only modest elevation.	Polychlorinated Dibenzodioxins	47-51	flavin containing monooxygenase 3	Mus musculus	9-13	
16214954-7	2006	The flavin-containing monooxygenases, Fmo2 and Fmo3, considered previously to be uninducible, were highly induced by TCDD in an AHR-dependent manner.	Polychlorinated Dibenzodioxins	117-121	flavin containing monooxygenase 3	Mus musculus	47-51	
18765683-2	2008	Our recent microarray studies revealed induction of FMO2 and FMO3 mRNAs by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver of mice with wild-type aryl hydrocarbon receptor (AHR) but not in Ahr-null mice.	Polychlorinated Dibenzodioxins	75-110	flavin containing monooxygenase 3	Mus musculus	61-65	
18765683-2	2008	Our recent microarray studies revealed induction of FMO2 and FMO3 mRNAs by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver of mice with wild-type aryl hydrocarbon receptor (AHR) but not in Ahr-null mice.	Polychlorinated Dibenzodioxins	112-116	flavin containing monooxygenase 3	Mus musculus	61-65	
18765683-5	2008	In adult female mice basal FMO3 mRNA is high and was not induced at 4 h but was elevated 8-fold at 24 h. FMO5 mRNA was significantly down-regulated by TCDD in both male and female adult mice.	Polychlorinated Dibenzodioxins	151-155	flavin containing monooxygenase 3	Mus musculus	27-31	
18765683-6	2008	Juvenile mice show no sex difference in response to TCDD; FMO3 was induced 4 to 6-fold by TCDD in both sexes.	Polychlorinated Dibenzodioxins	90-94	flavin containing monooxygenase 3	Mus musculus	58-62	
18765683-7	2008	Chromatin immunoprecipitation demonstrated recruitment of AHR and aryl hydrocarbon nuclear translocator proteins to Fmo3 regulatory regions, suggesting that induction by TCDD is a primary AHR-mediated event.	Polychlorinated Dibenzodioxins	170-174	flavin containing monooxygenase 3	Mus musculus	116-120	
18765683-8	2008	Although FMO2 and FMO3 mRNAs were highly induced by TCDD in adult males, overall FMO catalytic activity increased only modestly.	Polychlorinated Dibenzodioxins	52-56	flavin containing monooxygenase 3	Mus musculus	18-22	
20036217-8	2010	Similarly, treatment with 10 microg/kg TCDD alone increased Fmo3 mRNA 130- and 180-fold in the sham-castrated and castrated mice compared to their controls respectively, whereas, Fmo3 mRNA increased approximately 1900-fold between the sham control and castrated TCDD-treated mice.	Polychlorinated Dibenzodioxins	39-43	flavin containing monooxygenase 3	Mus musculus	60-64	
20036217-8	2010	Similarly, treatment with 10 microg/kg TCDD alone increased Fmo3 mRNA 130- and 180-fold in the sham-castrated and castrated mice compared to their controls respectively, whereas, Fmo3 mRNA increased approximately 1900-fold between the sham control and castrated TCDD-treated mice.	Polychlorinated Dibenzodioxins	39-43	flavin containing monooxygenase 3	Mus musculus	179-183	
20036217-9	2010	An increase in hepatic Fmo3 protein in TCDD-treated mice was observed by immunoblotting and assaying methionine S-oxidase activity.	Polychlorinated Dibenzodioxins	39-43	flavin containing monooxygenase 3	Mus musculus	23-27	
35448550-4	2022	Here, we show that TCDD exposure in mice profoundly stimulates the hepatic expression of flavin-containing monooxygenase 3 (Fmo3), which is a hepatic xenobiotic metabolizing enzyme that is also responsible for the production of the gut microbiome-associated metabolite trimethylamine N-oxide (TMAO).	Polychlorinated Dibenzodioxins	19-23	flavin containing monooxygenase 3	Mus musculus	89-122	
35448550-4	2022	Here, we show that TCDD exposure in mice profoundly stimulates the hepatic expression of flavin-containing monooxygenase 3 (Fmo3), which is a hepatic xenobiotic metabolizing enzyme that is also responsible for the production of the gut microbiome-associated metabolite trimethylamine N-oxide (TMAO).	Polychlorinated Dibenzodioxins	19-23	flavin containing monooxygenase 3	Mus musculus	124-128	
35448550-6	2022	Therefore, here, we examined TCDD-induced alterations in the gut microbiome, host liver transcriptome, and glucose tolerance in Fmo3+/+ and Fmo3-/- mice.	Polychlorinated Dibenzodioxins	29-33	flavin containing monooxygenase 3	Mus musculus	128-132	
35448550-6	2022	Therefore, here, we examined TCDD-induced alterations in the gut microbiome, host liver transcriptome, and glucose tolerance in Fmo3+/+ and Fmo3-/- mice.	Polychlorinated Dibenzodioxins	29-33	flavin containing monooxygenase 3	Mus musculus	140-144	
35448550-7	2022	Our results show that Fmo3 is a critical component of the transcriptional response to TCDD, impacting the gut microbiome, host liver transcriptome, and systemic glucose tolerance.	Polychlorinated Dibenzodioxins	86-90	flavin containing monooxygenase 3	Mus musculus	22-26	
26290441-9	2015	4) A subset of genes demonstrated sex-dependent TCDD-induced transcriptional changes, including Fmo3 and Nr1i3, which were significantly induced in livers of male mice only.	Polychlorinated Dibenzodioxins	48-52	flavin containing monooxygenase 3	Mus musculus	96-100