PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30853873-5 2019 With the increase in TCDD (0.5-10 nM), the expression of TGF-beta3 increased, but at TCDD concentrations greater than 10 nM, the expression of TGF-beta3 reduced. Polychlorinated Dibenzodioxins 21-25 transforming growth factor, beta 3 Mus musculus 57-66 15668235-0 2005 Transforming growth factor-beta3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polychlorinated Dibenzodioxins 79-114 transforming growth factor, beta 3 Mus musculus 0-32 30853873-5 2019 With the increase in TCDD (0.5-10 nM), the expression of TGF-beta3 increased, but at TCDD concentrations greater than 10 nM, the expression of TGF-beta3 reduced. Polychlorinated Dibenzodioxins 21-25 transforming growth factor, beta 3 Mus musculus 143-152 30853873-9 2019 In addition, we found that the expression of p-Smad2, p-Smad3,and Smad7 were increased by TCDD, TGF-beta3, combination of TCDD and TGF-beta3, but the expression of Smad4 were decreased by TCDD, TGF-beta3, combination of TCDD and TGF-beta3. Polychlorinated Dibenzodioxins 90-94 transforming growth factor, beta 3 Mus musculus 131-140 30853873-9 2019 In addition, we found that the expression of p-Smad2, p-Smad3,and Smad7 were increased by TCDD, TGF-beta3, combination of TCDD and TGF-beta3, but the expression of Smad4 were decreased by TCDD, TGF-beta3, combination of TCDD and TGF-beta3. Polychlorinated Dibenzodioxins 90-94 transforming growth factor, beta 3 Mus musculus 131-140 30853873-9 2019 In addition, we found that the expression of p-Smad2, p-Smad3,and Smad7 were increased by TCDD, TGF-beta3, combination of TCDD and TGF-beta3, but the expression of Smad4 were decreased by TCDD, TGF-beta3, combination of TCDD and TGF-beta3. Polychlorinated Dibenzodioxins 90-94 transforming growth factor, beta 3 Mus musculus 131-140 30479586-4 2018 The result showed that with increase of TCDD (0.5 nM-10 nM), the expression of TGF-beta3 increased, but after 10 nM TCDD, the expression of TGF-beta3 reduced. Polychlorinated Dibenzodioxins 40-44 transforming growth factor, beta 3 Mus musculus 79-88 30479586-4 2018 The result showed that with increase of TCDD (0.5 nM-10 nM), the expression of TGF-beta3 increased, but after 10 nM TCDD, the expression of TGF-beta3 reduced. Polychlorinated Dibenzodioxins 40-44 transforming growth factor, beta 3 Mus musculus 140-149 30479586-4 2018 The result showed that with increase of TCDD (0.5 nM-10 nM), the expression of TGF-beta3 increased, but after 10 nM TCDD, the expression of TGF-beta3 reduced. Polychlorinated Dibenzodioxins 116-120 transforming growth factor, beta 3 Mus musculus 140-149 30479586-8 2018 In addition, we found that the expression of phosphorylated Smad2/3 and Smad7 was increased by 10 nM TCDD, 10 ng/mL TGF-beta3, or combination of 10 nM TCDD and 10 ng/mL TGF-beta3 induced, but the expression of Smad4 was decreased. Polychlorinated Dibenzodioxins 101-105 transforming growth factor, beta 3 Mus musculus 169-178 30479586-8 2018 In addition, we found that the expression of phosphorylated Smad2/3 and Smad7 was increased by 10 nM TCDD, 10 ng/mL TGF-beta3, or combination of 10 nM TCDD and 10 ng/mL TGF-beta3 induced, but the expression of Smad4 was decreased. Polychlorinated Dibenzodioxins 151-155 transforming growth factor, beta 3 Mus musculus 169-178 30479586-9 2018 These data revealed that the TGF-beta/Smad signaling pathway affected TCDD and TGF-beta3 in MEPM cells. Polychlorinated Dibenzodioxins 70-74 transforming growth factor, beta 3 Mus musculus 29-37 27279340-7 2016 On GD 13.5 and GD 14.5, TGF-beta3 mRNA expression, HAT activity and acetylated H3 levels were significantly increased in the TCDD group compared with the control. Polychlorinated Dibenzodioxins 125-129 transforming growth factor, beta 3 Mus musculus 24-33 27279340-9 2016 In conclusion, at the critical period of palate fusion (GD 13.5-14.5), TCDD significantly increased TGF-beta3 gene expression, HAT activity and H3 acetylation. Polychlorinated Dibenzodioxins 71-75 transforming growth factor, beta 3 Mus musculus 100-109 25619290-13 2014 Meanwhile, TCDD repressed the TGF-beta3 expression during the palatal development. Polychlorinated Dibenzodioxins 11-15 transforming growth factor, beta 3 Mus musculus 30-39 24599693-5 2014 Our results suggest that vitamin B12 may inhibit the expression of some cleft palate inducers such as TGF-beta3 and ALK5 in DEX+TCDD exposed mice, which may be beneficial against palatogenesis to some degree, even though we were unable to observe a protective role of vitamin B12 in morphological and histological alterations of palatal shelves induced by DEX and TCDD. Polychlorinated Dibenzodioxins 128-132 transforming growth factor, beta 3 Mus musculus 102-111 24599693-5 2014 Our results suggest that vitamin B12 may inhibit the expression of some cleft palate inducers such as TGF-beta3 and ALK5 in DEX+TCDD exposed mice, which may be beneficial against palatogenesis to some degree, even though we were unable to observe a protective role of vitamin B12 in morphological and histological alterations of palatal shelves induced by DEX and TCDD. Polychlorinated Dibenzodioxins 364-368 transforming growth factor, beta 3 Mus musculus 102-111 20350561-14 2010 TCDD increased IDO1, IDO2 and TGF-beta3 mRNA levels in BMDCs as compared to vehicle. Polychlorinated Dibenzodioxins 0-4 transforming growth factor, beta 3 Mus musculus 30-39 21097750-12 2011 TCDD-BMDCs displayed increased messenger RNA expression of the regulatory gene IDO2 and following LPS stimulation upregulated IDO1, IDO2, TGFbeta1, and TGFbeta3 gene expression. Polychlorinated Dibenzodioxins 0-4 transforming growth factor, beta 3 Mus musculus 152-160 22292409-16 2011 The TGF-beta3 promoters were at the un-methylation state both in the TCDD treated and control group. Polychlorinated Dibenzodioxins 69-73 transforming growth factor, beta 3 Mus musculus 4-13 20848923-8 2010 CONCLUSION: Combined effects of TCDD and DEX could induce a stable formation of cleft palate and down-regulated mRNA of TGF-beta3 and up-regulated Alk5 may contribute to the occurrence of cleft palate. Polychlorinated Dibenzodioxins 32-36 transforming growth factor, beta 3 Mus musculus 120-129 19783572-0 2009 Transforming growth factor-beta3 expression up-regulates on cleft palates induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice. Polychlorinated Dibenzodioxins 85-120 transforming growth factor, beta 3 Mus musculus 0-32 19783572-3 2009 In this developmental toxicity study, we investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the expression of TGF-beta3 in fetal mice. Polychlorinated Dibenzodioxins 69-104 transforming growth factor, beta 3 Mus musculus 133-142 19783572-3 2009 In this developmental toxicity study, we investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the expression of TGF-beta3 in fetal mice. Polychlorinated Dibenzodioxins 106-110 transforming growth factor, beta 3 Mus musculus 133-142 19783572-6 2009 We found that the expression of TGF-beta3 was gradually up-regulated in TCDD-treated group. Polychlorinated Dibenzodioxins 72-76 transforming growth factor, beta 3 Mus musculus 32-41 19783572-7 2009 These results suggest that cleft palate can be induced by TCDD exposure, the modification of TGF-beta3 is related to its pathogenesis. Polychlorinated Dibenzodioxins 58-62 transforming growth factor, beta 3 Mus musculus 93-102 18684927-8 2008 Several genes were significantly up-regulated in TCDD-CD4(+) cells including TGF-beta3, Blimp-1, and granzyme B, as well as genes associated with the IL12-Rb2 signaling pathway. Polychlorinated Dibenzodioxins 49-53 transforming growth factor, beta 3 Mus musculus 77-86