PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34564697-4 2021 Here, we show that combining TKI (imatinib, nilotinib, dasatinib, or asciminib) treatment with the small-molecule MCL1 inhibitor S63845 exerted strong synergistic antiviability and proapoptotic effects on CML lines and CD34+ stem/progenitor cells isolated from untreated CML patients in chronic phase. asciminib 69-78 CD34 molecule Homo sapiens 219-223 34659899-8 2021 Most importantly, we were able to show that the combinations "asciminib+ponatinib" and "asciminib+ponatinib+HU" produce synergistic apoptosis-inducing effects in CD34+/CD38- CML stem cells obtained from patients with chronic phase CML or BCR-ABL1 T315I+ CML blast phase. asciminib 62-71 CD34 molecule Homo sapiens 162-166 34659899-8 2021 Most importantly, we were able to show that the combinations "asciminib+ponatinib" and "asciminib+ponatinib+HU" produce synergistic apoptosis-inducing effects in CD34+/CD38- CML stem cells obtained from patients with chronic phase CML or BCR-ABL1 T315I+ CML blast phase. asciminib 88-97 CD34 molecule Homo sapiens 162-166