PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23029106-6 2012 However, while the inhibition of DNA topoisomerase 1 activity by FL118 was no better than the active form of irinotecan, SN-38 at 1 microM, FL118 effectively inhibited cancer cell growth at less than nM levels in a p53 status-independent manner. 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione 65-70 DNA topoisomerase I Homo sapiens 33-52