PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34966805-0 2021 NEFAs Influence the Inflammatory and Insulin Signaling Pathways Through TLR4 in Primary Calf Hepatocytes in vitro. Fatty Acids, Nonesterified 0-5 insulin Bos taurus 37-44 7771575-0 1995 Effect of arterially infused catecholamines and insulin on plasma glucose and free fatty acids in carp. Fatty Acids, Nonesterified 78-94 insulin Bos taurus 48-55 34966805-5 2021 Our experiments indicated that NEFAs could activate the NF-kappaB inflammatory signaling pathway and influence insulin resistance through TLR4. Fatty Acids, Nonesterified 31-36 insulin Bos taurus 111-118 34966805-6 2021 However, an inhibitor of TLR4 alleviated the inhibitory effects of NEFAs on the insulin pathway. Fatty Acids, Nonesterified 67-72 insulin Bos taurus 80-87 34966805-7 2021 In conclusion, all of these results indicate that high-dose NEFAs (2.4 mM) can activate the TLR4/NF-kappaB inflammatory signaling pathway and reduce the sensitivity of the insulin pathway through the TLR4/PI3K/AKT metabolic axis. Fatty Acids, Nonesterified 60-65 insulin Bos taurus 172-179 10219522-0 1999 Insulin-dependent whole-body glucose utilization and insulin-responses to glucose in week 9 and week 19 of lactation in dairy cows fed rumen-protected crystalline fat or free fatty acids. Fatty Acids, Nonesterified 170-186 insulin Bos taurus 0-7 10219522-1 1999 Whole-body insulin-dependent glucose utilization and insulin responses to glucose in euglycemic-hyperinsulinemic clamps (EHGC) and in hyperglycemic clamps (HGC) were evaluated in high yielding dairy cows fed rumen-protected fat (triglycerides), free fatty acids, or a starch-rich ration (n = 5 per group) in Week 9 and Week 19 of lactation. Fatty Acids, Nonesterified 245-261 insulin Bos taurus 11-18 7771575-3 1995 INfusion of bovine insulin in carp resulted in a long lasting (24 h) decrease of plasma free fatty acids (FFA; -0.41 +/- 0.06 mM) and glucose levels (-3.14 +/- 0.25 mM) compared with preinfusion levels at t = 0. Fatty Acids, Nonesterified 88-104 insulin Bos taurus 19-26 7771575-3 1995 INfusion of bovine insulin in carp resulted in a long lasting (24 h) decrease of plasma free fatty acids (FFA; -0.41 +/- 0.06 mM) and glucose levels (-3.14 +/- 0.25 mM) compared with preinfusion levels at t = 0. Fatty Acids, Nonesterified 106-109 insulin Bos taurus 19-26 30292556-11 2018 Higher insulin levels were needed in HEI cows than in CEI cows to elicit a similar decrement of nonesterified fatty acid concentration in prepartal IVGTT, suggesting reduced inhibition of lipolysis by insulin in HEI cows before parturition. Fatty Acids, Nonesterified 96-120 insulin Bos taurus 7-14 5071176-3 1972 When livers from fed rats were perfused with blood containing elevated concentrations of rat insulin or blood to which fructose was added, the oxidation of free fatty acids was depressed and their esterification was increased. Fatty Acids, Nonesterified 156-172 insulin Bos taurus 93-100 5071176-5 1972 Raised concentrations of insulin or addition of fructose increased secretion of triglyceride in very-low-density lipoproteins, but only insulin caused more of the free fatty acids taken up by the liver to be incorporated into very-low-density lipoproteins. Fatty Acids, Nonesterified 163-179 insulin Bos taurus 136-143 5071176-7 1972 When insulin and fructose were added together the combined effect on oxidation and esterification of free fatty acids and on secretion of very-low-density lipoproteins was equal to the sum of the effects of either alone. Fatty Acids, Nonesterified 101-117 insulin Bos taurus 5-12 31301559-6 2019 Thus, the objective of the present study was to evaluate the association between plasma NEFA concentration and metabolic hormones (insulin, ghrelin, and GIP) before parturition and their associations with the resumption of postpartum ovulations in dairy cows. Fatty Acids, Nonesterified 88-92 insulin Bos taurus 131-138 31301559-10 2019 Plasma NEFA concentration (H-NEFA mean = 294 muM, SD = 141.2; and L-NEFA mean = 122 muM, SD = 25.3) was correlated (P < 0.01) with plasma insulin (r = -0.374) and ghrelin (r = -0.346) concentrations but not with plasma GIP concentration (P = 0.64). Fatty Acids, Nonesterified 7-11 insulin Bos taurus 138-145 31301559-11 2019 The greater the concentration of insulin, the lesser the prepartum NEFA concentration (for each 1 muU/mL of plasma insulin increase, there is a decrease of 1.223 +- 0.62 muM of NEFA). Fatty Acids, Nonesterified 67-71 insulin Bos taurus 33-40 31301559-11 2019 The greater the concentration of insulin, the lesser the prepartum NEFA concentration (for each 1 muU/mL of plasma insulin increase, there is a decrease of 1.223 +- 0.62 muM of NEFA). Fatty Acids, Nonesterified 67-71 insulin Bos taurus 115-122 31301559-11 2019 The greater the concentration of insulin, the lesser the prepartum NEFA concentration (for each 1 muU/mL of plasma insulin increase, there is a decrease of 1.223 +- 0.62 muM of NEFA). Fatty Acids, Nonesterified 177-181 insulin Bos taurus 33-40 31301559-11 2019 The greater the concentration of insulin, the lesser the prepartum NEFA concentration (for each 1 muU/mL of plasma insulin increase, there is a decrease of 1.223 +- 0.62 muM of NEFA). Fatty Acids, Nonesterified 177-181 insulin Bos taurus 115-122 28063290-9 2017 At the level of the fatty acid metabolism, greater adiponectin concentrations were negatively correlated with lower NEFA levels during the HEC test reflecting the insulin responsiveness of the NEFA metabolism (r = -0.61, P = 0.08), whereas there was no association with the insulin sensitivity of the NEFA metabolism (r = -0.16, P = 0.67). Fatty Acids, Nonesterified 193-197 insulin Bos taurus 163-170 29602237-5 2018 PGC-1alpha and Mfn-2 overexpression significantly decreased the NEFA-induced ROS production and TNF-alpha and IL-6 mRNA expressions, reversed the inhibitory effect of NEFAs on mitochondrial function and attenuated the overactivation of the ROS-JNK/p38MAPK pathway, alleviated insulin resistance induced by NEFAs in cow hepatocytes and HepG2 cells. Fatty Acids, Nonesterified 64-68 insulin Bos taurus 276-283 29602237-5 2018 PGC-1alpha and Mfn-2 overexpression significantly decreased the NEFA-induced ROS production and TNF-alpha and IL-6 mRNA expressions, reversed the inhibitory effect of NEFAs on mitochondrial function and attenuated the overactivation of the ROS-JNK/p38MAPK pathway, alleviated insulin resistance induced by NEFAs in cow hepatocytes and HepG2 cells. Fatty Acids, Nonesterified 167-172 insulin Bos taurus 276-283 28069424-5 2017 Higher plasma insulin levels and decreased plasma free fatty acid levels were detected at 8h post insulin injection in A strain induced hypoglycemia. Fatty Acids, Nonesterified 50-65 insulin Bos taurus 98-105 28063290-9 2017 At the level of the fatty acid metabolism, greater adiponectin concentrations were negatively correlated with lower NEFA levels during the HEC test reflecting the insulin responsiveness of the NEFA metabolism (r = -0.61, P = 0.08), whereas there was no association with the insulin sensitivity of the NEFA metabolism (r = -0.16, P = 0.67). Fatty Acids, Nonesterified 193-197 insulin Bos taurus 163-170 22720937-2 2012 Reduced suppression of lipolysis by insulin facilitates mobilization of nonesterified fatty acids (NEFA) from adipose tissue, resulting in elevated plasma NEFA concentrations. Fatty Acids, Nonesterified 72-97 insulin Bos taurus 36-43 27209137-13 2016 In conclusion, differences in serum concentrations of NEFA between cows overfed energy prepartum and high blood concentrations of BHB are likely due to greater negative energy balance postpartum reflected in lower circulating concentrations of glucose and insulin and an increase in the total amount of mobilized adipose tissue mass rather than due to changes in adipose tissue insulin signaling. Fatty Acids, Nonesterified 54-58 insulin Bos taurus 256-263 28131575-0 2017 Responses of plasma glucose and nonesterified fatty acids to intravenous insulin tolerance tests in dairy cows during a 670-day lactation. Fatty Acids, Nonesterified 32-57 insulin Bos taurus 73-80 27638262-2 2016 The progressive recovery of insulin sensitivity as cows advance toward late lactation is accompanied by reductions in circulating nonesterified fatty acids (NEFA) and milk yield. Fatty Acids, Nonesterified 157-161 insulin Bos taurus 28-35 22720937-2 2012 Reduced suppression of lipolysis by insulin facilitates mobilization of nonesterified fatty acids (NEFA) from adipose tissue, resulting in elevated plasma NEFA concentrations. Fatty Acids, Nonesterified 99-103 insulin Bos taurus 36-43 12362450-1 2002 The objective of this experiment was to determine whether there is a dose of slow-release insulin (SRI) that decreases concentrations of plasma nonesterified fatty acids (NEFA) and liver triglyceride (TG) without decreasing plasma glucose concentration, dry matter intake (DMI), and milk yield. Fatty Acids, Nonesterified 144-169 insulin Bos taurus 90-97 17931417-6 2007 The method, "Revised Quantitative Insulin Sensitivity Check Index" (RQUICKI) is based on plasma concentrations of glucose, insulin and free fatty acids (FFA) and it generates good and linear correlations with different estimates of insulin sensitivity in human populations. Fatty Acids, Nonesterified 135-151 insulin Bos taurus 34-41 17881684-1 2007 The objective was to investigate the relationship between elevated plasma nonesterified fatty acid (NEFA) concentration and insulin resistance in Holstein cows. Fatty Acids, Nonesterified 74-98 insulin Bos taurus 124-131 17881684-1 2007 The objective was to investigate the relationship between elevated plasma nonesterified fatty acid (NEFA) concentration and insulin resistance in Holstein cows. Fatty Acids, Nonesterified 100-104 insulin Bos taurus 124-131 17699036-11 2007 Cows that received isoflupredone with insulin and isoflupredone alone had higher beta-hydroxybutyrate and nonesterified fatty acid concentrations 1 wk after treatment compared with control cows. Fatty Acids, Nonesterified 106-130 insulin Bos taurus 38-45 17517713-16 2007 The induction of insulin resistance by TG, NEFA, or both may increase the availability of glucogenic nutrients to the periparturient dairy cow. Fatty Acids, Nonesterified 43-47 insulin Bos taurus 17-24 15129009-10 2004 Insulin treatment also resulted in reduced circulating nonesterified fatty acids, and increased circulating total and free insulin-like growth factor-I concentrations. Fatty Acids, Nonesterified 55-80 insulin Bos taurus 0-7 12362450-1 2002 The objective of this experiment was to determine whether there is a dose of slow-release insulin (SRI) that decreases concentrations of plasma nonesterified fatty acids (NEFA) and liver triglyceride (TG) without decreasing plasma glucose concentration, dry matter intake (DMI), and milk yield. Fatty Acids, Nonesterified 171-175 insulin Bos taurus 90-97 11781499-1 2001 Circulating free fatty acids (FFAs) are elevated in various disorders like states of insulin resistance, and an increase of FFAs has been reported to be associated with endothelial dysfunction. Fatty Acids, Nonesterified 12-28 insulin Bos taurus 85-92