PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24065523-3 2013 Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-alpha (TNF-alpha), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Fatty Acids, Nonesterified 0-16 interleukin 6 Homo sapiens 111-124 24065523-3 2013 Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-alpha (TNF-alpha), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Fatty Acids, Nonesterified 0-16 interleukin 6 Homo sapiens 126-130 15075299-3 2004 In the present study, we hypothesized that suppressing lipolysis, and subsequent free fatty acid (FFA) availability, would result in a compensatory elevation in IL-6 at rest and during exercise. Fatty Acids, Nonesterified 81-96 interleukin 6 Homo sapiens 161-165 24378274-11 2013 A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha. Fatty Acids, Nonesterified 204-207 interleukin 6 Homo sapiens 61-65 24378274-11 2013 A time- and dose-dependent upregulation of the expression of IL-6 and IL-8 mRNA was observed during the treatment at 3 and 24 h. In contrast, TNF-alpha mRNA expression was highly upregulated at 3 h after FFA exposure but returned to control values at 24 h. In conclusion, hepatocytes exposed in vitro for a short time to low FFA concentrations showed a significant upregulation of IL-6 and IL-8 to,and a rapid but transitory elevation of TNF-alpha. Fatty Acids, Nonesterified 325-328 interleukin 6 Homo sapiens 61-65 21054880-5 2010 We have examined whether saturated nonesterified fatty acids (NEFA) and insulin, which increase in concentration with developing insulin resistance, can trigger the production of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human monocytes. Fatty Acids, Nonesterified 62-66 interleukin 6 Homo sapiens 179-197 20526368-4 2010 Increased levels of free fatty acids (FFA), as observed in obese patients, can induce IL-6 production in various cell types. Fatty Acids, Nonesterified 20-36 interleukin 6 Homo sapiens 86-90 20526368-4 2010 Increased levels of free fatty acids (FFA), as observed in obese patients, can induce IL-6 production in various cell types. Fatty Acids, Nonesterified 38-41 interleukin 6 Homo sapiens 86-90 17185492-8 2007 IL-6 is a cytokine that may have beneficial systemic effects by mobilizing glucose from the liver and free fatty acids from the adipose tissue and providing them to the strenuously working respiratory muscles. Fatty Acids, Nonesterified 102-118 interleukin 6 Homo sapiens 0-4 15561952-10 2004 We show here that the common plasma FFA palmitate induces high levels of IL-6 in CAECs. Fatty Acids, Nonesterified 36-39 interleukin 6 Homo sapiens 73-77 23650203-1 2013 SCOPE: We aimed to study the effects of free fatty acids (FFAs) alone and combined with the exercise mimetics adrenaline and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in the production of IL6, IL15 and Irisin in muscle cells, using a time-sequential model. Fatty Acids, Nonesterified 40-56 interleukin 6 Homo sapiens 200-203 15075299-3 2004 In the present study, we hypothesized that suppressing lipolysis, and subsequent free fatty acid (FFA) availability, would result in a compensatory elevation in IL-6 at rest and during exercise. Fatty Acids, Nonesterified 98-101 interleukin 6 Homo sapiens 161-165 10720087-6 2000 Serum IL-6 levels correlated positively with fasting triglycerides, VLDL-triglycerides, and postload free fatty acids (r = 0.61, 0.65 and 0.60, respectively; P < 0.001) and negatively with high-density lipoprotein-cholesterol (r = -0.42, P < 0.05). Fatty Acids, Nonesterified 101-117 interleukin 6 Homo sapiens 6-10 12794182-5 2003 Furthermore, IL-6 has been demonstrated to have a lipolytic effect, thus possibly playing a role in mobilisation of energy as free fatty acids (FFA) in response to exercise. Fatty Acids, Nonesterified 126-142 interleukin 6 Homo sapiens 13-17 11287357-10 2001 Plasma IL-6 was significantly associated with plasma nonesterified fatty acid levels (r = 0.49, P < 0.002). Fatty Acids, Nonesterified 53-77 interleukin 6 Homo sapiens 7-11 30598636-1 2018 Objective: To investigate the role and possible molecular mechanism of Kruppel-like factor 7 (KLF7) in the TLR4/NF-kappaB/IL-6 inflammatory signaling pathway activated by free fatty acids (FFA). Fatty Acids, Nonesterified 171-187 interleukin 6 Homo sapiens 122-126 34622233-0 2021 Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men. Fatty Acids, Nonesterified 49-65 interleukin 6 Homo sapiens 20-24 35115578-10 2022 The dimensions of response to the exercises observed through the changes in the concentration of 25(OH)D3, PTH, NEFA and glycerol were associated with the significant increases of IL-6 level. Fatty Acids, Nonesterified 112-116 interleukin 6 Homo sapiens 180-184 28606092-6 2017 In addition, we found an increase in the cytokine secretion of IL-6 and chemokine IL-8 in FFA-treated HC in comparison to the untreated HC. Fatty Acids, Nonesterified 90-93 interleukin 6 Homo sapiens 63-67 28990058-7 2017 The results demonstrated that MCP-1 and IL-6 secretion, as well as TNF-alpha expression, were significantly increased following FFA treatment, which was attenuated by Rb1 in a dose-dependent manner. Fatty Acids, Nonesterified 128-131 interleukin 6 Homo sapiens 40-44 30001663-4 2018 Mechanistically, IL-6 induces the release of free fatty acid (FFA) and leptin from adipocytes thereby affecting liver metabolism and pancreatic beta-cell function, respectively. Fatty Acids, Nonesterified 45-60 interleukin 6 Homo sapiens 17-21 27186262-0 2016 Overexpression of variant PNPLA3 gene at I148M position causes malignant transformation of hepatocytes via IL-6-JAK2/STAT3 pathway in low dose free fatty acid exposure: a laboratory investigation in vitro and in vivo. Fatty Acids, Nonesterified 143-158 interleukin 6 Homo sapiens 107-111 23941872-3 2013 As such, the report that increased release of free fatty acids (FFA) via lipolysis from skeletal muscle, but not from adipose tissue, is responsible for the increased systemic lipolysis during IL-6 infusion in healthy humans is somewhat unexpected (26). Fatty Acids, Nonesterified 46-62 interleukin 6 Homo sapiens 193-197 24285492-8 2015 RESULTS: In rheumatoid arthritis synovial fibroblasts (RASF), FFA dose-dependently enhanced the secretion of the proinflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, as well as the matrix-degrading enzymes pro-MMP1 and MMP3. Fatty Acids, Nonesterified 62-65 interleukin 6 Homo sapiens 138-142 26352938-7 2015 Furthermore, a significant correlation was observed between the levels of IL-6 immediately post-exercise and free fatty acids 2 h post-exercise in the evening (r = 0.68, P < 0.01). Fatty Acids, Nonesterified 109-125 interleukin 6 Homo sapiens 74-78 26352938-9 2015 In addition, IL-6 was involved in increasing free fatty acids, suggesting that the evening is more effective for exercise-induced lipolysis compared with the morning. Fatty Acids, Nonesterified 45-61 interleukin 6 Homo sapiens 13-17