PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32183037-4 2020 The inflammatory kinase c-jun N-terminal kinase (JNK) responds to various cellular stress signals activated by cytokines, free fatty acids and hyperglycemia, and is a key mediator in the transition between obesity and T2D. Fatty Acids, Nonesterified 122-138 mitogen-activated protein kinase 8 Homo sapiens 24-47 34902437-13 2022 SIGNIFICANCE: To summarize, the protective effect of PSTi8 on FFA-induced insulin resistance is mediated via inhibition of JNK signaling, which leads to decreased ROS generation and enhanced insulin sensitivity. Fatty Acids, Nonesterified 62-65 mitogen-activated protein kinase 8 Homo sapiens 123-126 32183037-4 2020 The inflammatory kinase c-jun N-terminal kinase (JNK) responds to various cellular stress signals activated by cytokines, free fatty acids and hyperglycemia, and is a key mediator in the transition between obesity and T2D. Fatty Acids, Nonesterified 122-138 mitogen-activated protein kinase 8 Homo sapiens 49-52 29602237-0 2018 NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis. Fatty Acids, Nonesterified 0-4 mitogen-activated protein kinase 8 Homo sapiens 57-60 29602237-5 2018 PGC-1alpha and Mfn-2 overexpression significantly decreased the NEFA-induced ROS production and TNF-alpha and IL-6 mRNA expressions, reversed the inhibitory effect of NEFAs on mitochondrial function and attenuated the overactivation of the ROS-JNK/p38MAPK pathway, alleviated insulin resistance induced by NEFAs in cow hepatocytes and HepG2 cells. Fatty Acids, Nonesterified 64-68 mitogen-activated protein kinase 8 Homo sapiens 244-247 29602237-5 2018 PGC-1alpha and Mfn-2 overexpression significantly decreased the NEFA-induced ROS production and TNF-alpha and IL-6 mRNA expressions, reversed the inhibitory effect of NEFAs on mitochondrial function and attenuated the overactivation of the ROS-JNK/p38MAPK pathway, alleviated insulin resistance induced by NEFAs in cow hepatocytes and HepG2 cells. Fatty Acids, Nonesterified 167-172 mitogen-activated protein kinase 8 Homo sapiens 244-247 29602237-6 2018 These findings indicate that NEFAs induce mitochondrial dysfunction and insulin resistance mediated by the ROS-JNK/p38MAPK pathway. Fatty Acids, Nonesterified 29-34 mitogen-activated protein kinase 8 Homo sapiens 111-114 23512893-0 2013 IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFalpha expression in human subcutaneous preadipocytes. Fatty Acids, Nonesterified 17-20 mitogen-activated protein kinase 8 Homo sapiens 43-47 26054298-10 2015 These results suggest that JNK regulates activation of Panx1 channels, and provide evidence that Pannexin1-dependent pathophysiological eATP release in lipoapoptosis is capable of stimulating migration of human monocytes, and may participate in the recruitment of monocytes in chronic liver injury induced by saturated FFA. Fatty Acids, Nonesterified 319-322 mitogen-activated protein kinase 8 Homo sapiens 27-30 28930674-3 2017 Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH2-terminal kinase (JNK) signaling pathway is implicated in this process. Fatty Acids, Nonesterified 0-15 mitogen-activated protein kinase 8 Homo sapiens 109-112 28930674-3 2017 Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH2-terminal kinase (JNK) signaling pathway is implicated in this process. Fatty Acids, Nonesterified 17-20 mitogen-activated protein kinase 8 Homo sapiens 109-112 23512893-1 2013 OBJECTIVE: Free fatty acids (FFAs) are increased in visceral fat and contribute to insulin resistance through multiple mechanisms, including c-Jun N-terminal kinase (JNK) activation and expression of TNFalpha. Fatty Acids, Nonesterified 11-27 mitogen-activated protein kinase 8 Homo sapiens 141-164 23512893-1 2013 OBJECTIVE: Free fatty acids (FFAs) are increased in visceral fat and contribute to insulin resistance through multiple mechanisms, including c-Jun N-terminal kinase (JNK) activation and expression of TNFalpha. Fatty Acids, Nonesterified 11-27 mitogen-activated protein kinase 8 Homo sapiens 166-169 23512893-12 2013 CONCLUSIONS: IGF-I attenuated FFA-induced JNK1 phosphorylation and TNFalpha expression through activation of AKT in human subcutaneous but not omental preadipocytes. Fatty Acids, Nonesterified 30-33 mitogen-activated protein kinase 8 Homo sapiens 42-46 17916553-0 2007 A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. Fatty Acids, Nonesterified 91-107 mitogen-activated protein kinase 8 Homo sapiens 144-147 16085647-0 2005 JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. Fatty Acids, Nonesterified 44-59 mitogen-activated protein kinase 8 Homo sapiens 0-35 16085647-7 2005 We found that JNK activation by FFAs was not inhibited by blocking TNF-alpha signaling, whereas the FFA-induced increase in TNF-alpha secretion was inhibited by RNA interference-mediated JNK knockdown. Fatty Acids, Nonesterified 32-35 mitogen-activated protein kinase 8 Homo sapiens 14-17 16085647-8 2005 Together, these results indicate that 1) JNK can be activated by FFAs through TNF-alpha-independent mechanisms, 2) activated JNK is a major contributor to FFA-induced cellular insulin resistance, and 3) TNF-alpha is an autocrine/paracrine downstream effector of activated JNK that can also mediate insulin resistance. Fatty Acids, Nonesterified 65-68 mitogen-activated protein kinase 8 Homo sapiens 41-44 22226987-4 2012 Free fatty acids mediate adipose tissue signalling through toll-like receptor 4 and the expression of these pro-inflammatory mediators via NF-kappaB or JNK. Fatty Acids, Nonesterified 0-16 mitogen-activated protein kinase 8 Homo sapiens 152-155 21505982-0 2011 Genistein reverses free fatty acid-induced insulin resistance in HepG2 hepatocytes through targeting JNK. Fatty Acids, Nonesterified 19-34 mitogen-activated protein kinase 8 Homo sapiens 101-104 17470478-14 2007 CONCLUSION: Our results suggest that FFA induced hepatocyte steatosis sensitises to TRAIL by a DR5 mediated JNK dependent mechanism. Fatty Acids, Nonesterified 37-40 mitogen-activated protein kinase 8 Homo sapiens 108-111 16932311-4 2006 Both free fatty acids and adipocytokines activate inflammatory pathways that include protein kinase C, the transcription factor nuclear factor kappaB, and c-Jun N-terminal kinase 1 and can thereby accelerate the progression of hepatic steatosis to nonalcoholic steatohepatitis and cirrhosis. Fatty Acids, Nonesterified 5-21 mitogen-activated protein kinase 8 Homo sapiens 155-180