PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24923354-14 2014 The Ca(2+) -independent phospholipase A2 (iPLA2 ), a FFA (free fatty acids)-generating membrane-attached mitochondrial phospholipase, is potential to regulate ROS (reactive oxygen species) generation by mitochondria. Fatty Acids, Nonesterified 58-74 phospholipase A2 group IB Rattus norvegicus 24-40 19775433-1 2009 BACKGROUND: Phospholipase A2 liberates free fatty acids and lysophospholipids upon hydrolysis of phospholipids and these products are often associated with detrimental effects such as inflammation and cerebral ischemia. Fatty Acids, Nonesterified 39-55 phospholipase A2 group IB Rattus norvegicus 12-28 18528752-7 2008 Overall data suggest that iPLA(2), a primary PLA(2) isoform in cerebral cortex, displays a housekeeping role in development and neurite outgrowth in cortical neurons in vitro probably via maintaining phospholipid membrane remodeling rather than generating free fatty acids and lysophospholipids. Fatty Acids, Nonesterified 256-272 phospholipase A2 group IB Rattus norvegicus 27-33 12144867-1 2002 BACKGROUND: Phospholipase A(2) (PLA(2)) catalyses the release of free fatty acids used for eicosanoid biosynthesis. Fatty Acids, Nonesterified 65-81 phospholipase A2 group IB Rattus norvegicus 12-30 11928070-2 2002 Thermal destabilization of the receptor with arachidonic acid along with digestion of membrane with phospholipase A2 and reversal of these effects when BSA was used as fatty acids scavenger, may indicate that free fatty acids are responsible for instability of the LH/hCG receptor. Fatty Acids, Nonesterified 209-225 phospholipase A2 group IB Rattus norvegicus 100-116 12144867-1 2002 BACKGROUND: Phospholipase A(2) (PLA(2)) catalyses the release of free fatty acids used for eicosanoid biosynthesis. Fatty Acids, Nonesterified 65-81 phospholipase A2 group IB Rattus norvegicus 32-38 11420051-3 2001 Studies using double-labelled PC and 2,3-diphosphoglycerate (as a phospholipase D inhibitor) showed that they were produced through different pathways: free fatty acid was released by phospholipase A2 (PLA2) while 1,2-diacylglycerol may be produced by sequential action of phospholipase D and phosphatidate phosphatase. Fatty Acids, Nonesterified 152-167 phospholipase A2 group IB Rattus norvegicus 184-200 11420051-3 2001 Studies using double-labelled PC and 2,3-diphosphoglycerate (as a phospholipase D inhibitor) showed that they were produced through different pathways: free fatty acid was released by phospholipase A2 (PLA2) while 1,2-diacylglycerol may be produced by sequential action of phospholipase D and phosphatidate phosphatase. Fatty Acids, Nonesterified 152-167 phospholipase A2 group IB Rattus norvegicus 202-206 11693379-4 2001 In membranes stored at -20 degrees C, the loss of binding is attributed to increased membrane fluidity by phospholipase A2 action on membrane phospholipids, resulting in an increase of free fatty acids. Fatty Acids, Nonesterified 185-201 phospholipase A2 group IB Rattus norvegicus 106-122 11432454-5 2001 The results of the present study, thus, demonstrate that phospholipase A2-linked free fatty acids and lysoPC are employed in the sustained facilitation of hippocampal neurotransmission, suggesting a significant role of a phospholipase A2 signaling pathway in the neuroplasticity. Fatty Acids, Nonesterified 81-97 phospholipase A2 group IB Rattus norvegicus 57-73 11432454-5 2001 The results of the present study, thus, demonstrate that phospholipase A2-linked free fatty acids and lysoPC are employed in the sustained facilitation of hippocampal neurotransmission, suggesting a significant role of a phospholipase A2 signaling pathway in the neuroplasticity. Fatty Acids, Nonesterified 81-97 phospholipase A2 group IB Rattus norvegicus 221-237 8648901-1 1996 Free fatty acids (FFA) and lysophospholipids accumulate during hypoxia (H) in rat proximal tubular epithelial cells partly as a result of increased phospholipase A2 (PLA2) activity. Fatty Acids, Nonesterified 0-16 phospholipase A2 group IB Rattus norvegicus 148-164 9663696-8 1998 These results suggest that free fatty acids are directly responsible for the observed effects induced by phospholipase A2 isoforms on oxygen consumption experiments. Fatty Acids, Nonesterified 27-43 phospholipase A2 group IB Rattus norvegicus 105-121 9350841-0 1997 Role of phospholipase A2 in the release of free fatty acids during ischemia-reperfusion in the rat cerebral cortex. Fatty Acids, Nonesterified 43-59 phospholipase A2 group IB Rattus norvegicus 8-24 8648901-1 1996 Free fatty acids (FFA) and lysophospholipids accumulate during hypoxia (H) in rat proximal tubular epithelial cells partly as a result of increased phospholipase A2 (PLA2) activity. Fatty Acids, Nonesterified 0-16 phospholipase A2 group IB Rattus norvegicus 166-170 8594879-10 1995 These studies provide direct evidence for PLA2 activation during hypoxia and suggest that multiple mechanisms regulate free fatty acid release associated with hypoxia injury. Fatty Acids, Nonesterified 119-134 phospholipase A2 group IB Rattus norvegicus 42-46 1532028-8 1992 These results indicate that the release of free fatty acids during the first 2 minutes of ischemia can be attributed mostly to the action of phospholipase C, and that the activation of phospholipase C further influences the activation of phospholipase A2 in the subsequent course, while phospholipase A2 predominantly acts after 2 minutes of ischemia. Fatty Acids, Nonesterified 43-59 phospholipase A2 group IB Rattus norvegicus 238-254 7844475-12 1995 The present results confirmed recent work showing that lipase and phospholipase A2 probably cause cell damage through release of free fatty acids and lysolecithin. Fatty Acids, Nonesterified 129-145 phospholipase A2 group IB Rattus norvegicus 66-82 7845615-5 1994 Treating the rat brain membranes with phospholipase A2 which released free fatty acids including DHA, significantly stimulated the DG kinase activity. Fatty Acids, Nonesterified 70-86 phospholipase A2 group IB Rattus norvegicus 38-54 1382129-1 1992 Phospholipase A2 (PLA2) activity results in the formation of lysophospholipids and free fatty acids which may contribute to ischemic myocardial dysfunction. Fatty Acids, Nonesterified 83-99 phospholipase A2 group IB Rattus norvegicus 0-16 1382129-1 1992 Phospholipase A2 (PLA2) activity results in the formation of lysophospholipids and free fatty acids which may contribute to ischemic myocardial dysfunction. Fatty Acids, Nonesterified 83-99 phospholipase A2 group IB Rattus norvegicus 18-22 1532028-8 1992 These results indicate that the release of free fatty acids during the first 2 minutes of ischemia can be attributed mostly to the action of phospholipase C, and that the activation of phospholipase C further influences the activation of phospholipase A2 in the subsequent course, while phospholipase A2 predominantly acts after 2 minutes of ischemia. Fatty Acids, Nonesterified 43-59 phospholipase A2 group IB Rattus norvegicus 287-303 2343144-4 1990 N. n. atra PLA2, beta-BuTX, and notexin (all 50 nM) produced a time dependent rise in free fatty acids as measured in synaptic plasma membranes isolated from treated synaptosomes. Fatty Acids, Nonesterified 86-102 phospholipase A2 group IB Rattus norvegicus 11-15 1608291-3 1992 Phospholipase A2 activation results in the formation of lysophospholipids and free fatty acids. Fatty Acids, Nonesterified 78-94 phospholipase A2 group IB Rattus norvegicus 0-16 2248970-4 1990 Incubation of intact nuclei with phospholipase A2 increased nuclear INB-activity in a time- and dose-dependent manner; this was correlated with a rise of free fatty acid concentration in the ether extract. Fatty Acids, Nonesterified 154-169 phospholipase A2 group IB Rattus norvegicus 33-49 3968975-3 1985 One hour later, regions around the cannulae tracts in PLA2-treated rats contained over 2.5 times more FFA than saline-injected controls, and 3H-dihydromorphine binding was reduced on average more than 70%. Fatty Acids, Nonesterified 102-105 phospholipase A2 group IB Rattus norvegicus 54-58 2447244-5 1988 The removal of free fatty acids by addition of bovine serum albumin both prevented and reversed the effect of PLA2. Fatty Acids, Nonesterified 15-31 phospholipase A2 group IB Rattus norvegicus 110-114 3495296-5 1987 Thus, in the presence of phospholipase A2 in liver microsomes of non-induced rats, when the phospholipid hydrolysis products are accumulated at low concentrations, 7-ethoxycumarin deethylase is inhibited by lysophospholipids but not by free fatty acids. Fatty Acids, Nonesterified 236-252 phospholipase A2 group IB Rattus norvegicus 25-41 3490281-5 1986 Under normal conditions the damaging effect of phospholipase A2 on cytochrome P-450 is mainly provided for by lysophospholipids, while under vitamin E deficiency both lysophospholipids and free fatty acids exert a damaging action. Fatty Acids, Nonesterified 189-205 phospholipase A2 group IB Rattus norvegicus 47-63 6097234-6 1984 This was associated with an increase of AA in free fatty acids (FFA), indicating an enhanced activity of phospholipase A2. Fatty Acids, Nonesterified 46-62 phospholipase A2 group IB Rattus norvegicus 105-121 7464984-9 1980 The increased hydrolysis of polyunsaturated acyl groups in brain membrane phosphoglycerides due to the ischemic and hypoxic treatments seemed to correlate well with the implication of phospholipase A(2) involvement in eliciting the increase in free fatty acids during brain stimulation. Fatty Acids, Nonesterified 244-260 phospholipase A2 group IB Rattus norvegicus 184-202 25971887-1 2015 BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Fatty Acids, Nonesterified 168-184 phospholipase A2 group IB Rattus norvegicus 12-28 638160-7 1978 Phospholipase A2 and phospholipase A1 deacylated dipalmitoyl phophatidylcholine to the corresponding lyso compound and free fatty acid. Fatty Acids, Nonesterified 119-134 phospholipase A2 group IB Rattus norvegicus 0-16 25971887-1 2015 BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Fatty Acids, Nonesterified 168-184 phospholipase A2 group IB Rattus norvegicus 30-34 25971887-1 2015 BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Fatty Acids, Nonesterified 186-189 phospholipase A2 group IB Rattus norvegicus 12-28 25971887-1 2015 BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Fatty Acids, Nonesterified 186-189 phospholipase A2 group IB Rattus norvegicus 30-34