PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23317181-7 2012 Bufalin, bufotalin and gamabufotalin, key bufadienolides, significantly sensitize human breast cancer cells with differing ER-alpha status to apoptosis induction by the TNF-related apoptosis-inducing ligand (TRAIL). gamabufotalin 23-36 estrogen receptor 1 Homo sapiens 123-131 21259053-4 2011 In the current study, we found that bufalin, bufotalin and gamabufotalin, key members of bufadienolides isolated from a traditional Chinese medicine ChanSu, significantly potentiated human breast cancer cells with different status of ER-alpha to apoptosis induction of TRAIL, as evidenced by enhanced Annexin V/FITC positive cells (apoptotic cells), cytoplasmic histone-associated-DNA-fragments, membrane permeability transition (MPT), caspases activation and PARP cleavage. gamabufotalin 59-72 estrogen receptor 1 Homo sapiens 234-242