PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15692831-11	2005	CONCLUSION: These results show that some EPHX1 haplotypes are associated with altered CBZ-epoxide metabolism.	carbamazepine epoxide	86-97	epoxide hydrolase 1	Homo sapiens	41-46	
2501059-2	1989	In this study, therapeutic concentrations of valproic acid (less than 1 mmol/L) and valpromide (less than 10 mumol/L) inhibited hydrolysis of carbamazepine epoxide and styrene oxide in human liver microsomes and in preparations of purified human liver microsomal epoxide hydrolase.	carbamazepine epoxide	142-163	epoxide hydrolase 1	Homo sapiens	252-280	
24861996-8	2014	EPHX1 c.337T>C polymorphisms may contribute to the risk of severe CBZ-SJS/TEN by increasing the concentration of a CBZ metabolite, CBZ-10,11-epoxide, in patients with epilepsy.	carbamazepine epoxide	134-151	epoxide hydrolase 1	Homo sapiens	0-5	
17375979-13	2007	Likewise, the active metabolite of carbamazepine, carbamazepine-10,11-epoxide, is transformed by the microsomal epoxide hydrolase, an enzyme that is also highly polymorphic, but the pharmacokinetic and clinical consequences still need to be evaluated.	carbamazepine epoxide	50-77	epoxide hydrolase 1	Homo sapiens	101-129	
31650507-7	2019	EPHX1 rs1051740 polymorphism was significantly associated with adjusted concentrations of both carbamazepine (CC vs. TT: P = 0.02; CC vs. CT + TT: P = 0.005) and carbamazepine-10,11-epoxide (CC vs. CT + TT: P = 0.03).	carbamazepine epoxide	162-189	epoxide hydrolase 1	Homo sapiens	0-5	
24817818-1	2014	BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the active metabolite of CBZ) by evaluating the variation in serum CBZ 10,11-epoxide levels 4 hours after administration of the drug.	carbamazepine epoxide	320-337	epoxide hydrolase 1	Homo sapiens	142-147	
15692831-0	2005	Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.	carbamazepine epoxide	69-96	epoxide hydrolase 1	Homo sapiens	24-29	
15692831-1	2005	OBJECTIVE: Microsomal epoxide hydrolase (mEH) is an enzyme that detoxifies reactive epoxides and catalyzes the biotransformation of carbamazepine-10,11-epoxide (CBZ-epoxide) to carbamazepine-10,11-diol (CBZ-diol).	carbamazepine epoxide	132-159	epoxide hydrolase 1	Homo sapiens	11-39	
15692831-1	2005	OBJECTIVE: Microsomal epoxide hydrolase (mEH) is an enzyme that detoxifies reactive epoxides and catalyzes the biotransformation of carbamazepine-10,11-epoxide (CBZ-epoxide) to carbamazepine-10,11-diol (CBZ-diol).	carbamazepine epoxide	161-172	epoxide hydrolase 1	Homo sapiens	11-39	
8453849-9	1993	We conclude that distribution of microsomal epoxide hydrolase activity in a study group can be measured pharmacokinetically by use of carbamazepine epoxide.	carbamazepine epoxide	134-155	epoxide hydrolase 1	Homo sapiens	33-61