PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21658435-0 2011 Administration of the 5-HT2C receptor antagonist SB-242084 into the nucleus accumbens blocks the expression of ethanol-induced behavioral sensitization in Albino Swiss mice. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 49-58 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 22-37 22512261-9 2012 administration or local injection into ACC(S) of the 5-HT(2C) receptor antagonist, SB-242084, suppressed voluntary alcohol-drinking behavior in the alcohol-exposed mice. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 85-94 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 54-72 23303047-9 2013 In contrast to the 2CKO phenotype in the 5-CSRTT, wild-type mice treated with the 5-HT2C receptor antagonist SB242084 exhibited diminished response inhibition, suggesting differing effects of acute pharmacological blockade and constitutive loss of 5-HT2C receptor activity. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 109-117 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 82-97 23303047-9 2013 In contrast to the 2CKO phenotype in the 5-CSRTT, wild-type mice treated with the 5-HT2C receptor antagonist SB242084 exhibited diminished response inhibition, suggesting differing effects of acute pharmacological blockade and constitutive loss of 5-HT2C receptor activity. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 109-117 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 248-263 23192316-9 2013 The 5-HT2C receptor antagonist SB242084 increased premature responding in WT mice only. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 31-39 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 4-19 23349838-7 2013 Furthermore, treatment with a 5-HT(2C)R antagonist (SB242084) increased insulin secretion from pancreatic islets isolated from db/db mice in a dose-dependent manner, but had no effect in islets from control mice. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 52-60 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 30-39 17141810-4 2007 The selective 5-HT(2C) receptor antagonist SB242084 (0.3mg/kg) reversed the mCPP-induced hypolocomotion into hyperlocomotion. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 43-51 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 14-31 18262506-8 2008 Here, we demonstrate that handling-induced convulsions are less severe in congenic vs. background strain mice in response to either a 5-HT2C receptor antagonist (SB242084) or a GABAB receptor agonist (baclofen), but not a GABAA receptor channel blocker (pentylenetetrazol). 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 162-170 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 134-149 16959056-2 2007 Here, we report that fluvoxamine (3-30 mg/kg), a selective serotonin reuptake inhibitor (SSRI), in the presence of SB 242084 (1-2 mg/kg), a selective 5-HT2C receptor antagonist, exerts appetite-suppressing effects while fluvoxamine or SB 242084 alone has no effect. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 115-124 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 150-165 17141810-5 2007 In contrast, MK212 induced hypolocomotion that was blocked by SB242084, indicating a specific 5-HT(2C) receptor involvement. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 62-70 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 94-111 33359368-4 2021 While the 5-HT2AR antagonist M100907 blocked the effect of DOI and the 5-HT2CR antagonist SB242084 blocked the effect of citalopram, neither antagonist blocked the effect of psilocybin. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 90-98 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 71-78 34130255-12 2021 If mice were treated with the selective 5-HT2CR antagonist SB 242084 (0.5 or 1 mg/kg) plus lorcaserin (3 mg/kg), a significantly increased HTR was observed, relative to vehicle (P = 0.01 and P = 0.03), however, the HTR was much lower than what was elicited by DOI or DOI plus lorcaserin. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 59-68 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 40-47 9225286-0 1997 SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 43-58 9225286-15 1997 The results suggest that SB 242084 is the first reported selective potent and brain penetrant 5-HT2C receptor antagonist and has anxiolytic-like activity, but does not possess either proconvulsant or hyperphagic properties which are characteristic of mutant mice lacking the 5-HT2C receptor. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 25-34 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 94-109 9225286-15 1997 The results suggest that SB 242084 is the first reported selective potent and brain penetrant 5-HT2C receptor antagonist and has anxiolytic-like activity, but does not possess either proconvulsant or hyperphagic properties which are characteristic of mutant mice lacking the 5-HT2C receptor. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 25-34 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 275-290 34803706-6 2021 Dose-dependent activation of 5-HT2CR by lorcaserin suppressed GSIS and SB242084 or knockdown of 5-HT2CR abolished lorcaserin"s effect in vitro. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 71-79 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 29-36 32123974-3 2020 OBJECTIVES: These experiments first assessed gambling and loss-chasing performance under different win/lose probabilities in C57Bl/6 mice, and then investigated the effects of antagonism of 5-HT2CR with SB242084, 5-HT1AR agonism with 8-OH-DPAT and modafinil, a putative cognitive enhancer. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 203-211 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 190-197 29548885-7 2018 Interestingly, prior injection of SB 242084 (a selective 5-HT2C antagonist) into the amygdala also blocked the MK-212 effects on OAA. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 34-43 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 57-63 31778691-7 2020 We found that intra-LHb infusion of SB242084, a selective 5-HT2CR antagonist alleviated AB and reduced the elevated c-Fos expression in the LHb of Post-EtOH rats. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 36-44 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 58-65 30412729-7 2019 Moreover, the blockade of ketamine-induced hypothermia by WAY-163909 was reversed by pretreatment with the selective 5-HT2C receptor antagonist SB-242084. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 144-153 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 117-132 31987863-5 2020 This effect was prevented by the 5-HT2CR antagonist SB242084. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 52-60 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 33-40 30353709-5 2018 Experiments utilized appetite stimulants which included a 5-hydroxytryptamine (5-HT) 2c receptor antagonist (SB242084), as the 5-HT2cR is implicated in central signaling of satiety. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 109-117 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 58-96 30353709-5 2018 Experiments utilized appetite stimulants which included a 5-hydroxytryptamine (5-HT) 2c receptor antagonist (SB242084), as the 5-HT2cR is implicated in central signaling of satiety. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 109-117 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 127-134 27480795-9 2017 Interestingly, 3-week isolation and treatment with agomelatine or the 5-hydroxytryptamine-2C (5-HT2C) receptor antagonist SB242084 reversed the anhedonic-like state in GluN2D KO mice. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 122-130 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 94-110 28588509-8 2017 The effects of fluoxetine, but not of d-amphetamine, were prevented by the selective 5-HT2C receptor antagonist SB242084. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 112-120 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 85-100 29367407-1 2018 The functionally selective 5-HT2C receptor ligand SB242084 can increase motivation and have rapid onset anti-depressant-like effects. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 50-58 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 27-33 27565217-10 2016 and 5-HT2C receptor antagonist SB242084 (1-5.6mg/kg, i.p.) 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 31-39 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 4-19 26308619-10 2015 SB 242084, a 5-HT2cR selective antagonist, can reverse the social behavior deficits observed in Pten haploinsufficient mice. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 13-20 25656481-7 2015 Increased IPSC activity was restored to baseline levels following bath application of the 5-HT2C receptor antagonist, SB 242084. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 118-127 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 90-105 23657439-7 2013 The specific 5-HT2C receptor antagonist SB242084 also led to enhanced response control in this task. 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline 40-48 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 13-28