PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28178592-8	2017	RESULTS: QA treatment significantly altered body weight, motor performance, oxidative defense (increased LPO, nitrite and decreased GSH), pro-inflammatory cytokines levels (TNF-alpha, IL-6 and IL-1beta), neurochemical level (GABA, glutamate, nor-epinephrine, dopamine, serotonin, HVA, DOPAC, 5-HIAA).	Quinolinic Acid	9-11	tumor necrosis factor	Rattus norvegicus	173-182	
21362433-7	2011	Besides quinolinic acid (300 nmol) significantly depleted the mitochondrial enzyme complex levels and increased TNF-alpha, IL-6 and caspase-3 (marker of apoptotic cell death) levels in the striatum.	Quinolinic Acid	8-23	tumor necrosis factor	Rattus norvegicus	112-121	
22392362-5	2012	Intrastriatal administration of quinolinic acid caused a significant reduction in body weight, motor dysfunction (impaired locomotor activity, rotarod performance, and beam walk test), oxidative damage (as evidenced by increase in lipid peroxidation, nitrite concentration, and depletion of super oxide dismutase and catalase), increased TNF-alpha and IL-6 levels as compared to the sham-treated animals.	Quinolinic Acid	32-47	tumor necrosis factor	Rattus norvegicus	338-347	
26078029-9	2015	QA treatment significantly altered body weight, locomotor activity, motor coordination, oxidative defense (increased LPO, nitrite, and decreased GSH), pro-inflammatory levels (TNF-alpha, IL-6 and IL-1beta), GABA, glutamate, catecholamines level (norepinephrine, dopamine, and serotonin and their metabolites), and purines level (adenosine, inosine, and hypoxanthine).	Quinolinic Acid	0-2	tumor necrosis factor	Rattus norvegicus	176-185	
24752928-6	2014	Single bilateral intrastriatal injection of QA (200 nmol/2 mul saline) significantly caused motor incordination, memory impairment, oxidative damage, decrease in biogenic amines levels, cellular alterations (TNF-alpha, IL-6, PGE2, PGF2alpha, caspase-3, BDNF, mitochondrial function) and damage of striatal neurons compared to the sham treatment.	Quinolinic Acid	44-46	tumor necrosis factor	Rattus norvegicus	208-217	
21112316-5	2011	Intrastriatal quinolinic acid administration leads to significant motor [locomotor (72% reduction), rotarod (55% reduction), balance beam walk performance] dysfunction coupled with the marked oxidative damage and increased neuroinflammatory markers [TNF-alpha (140%), IL-6 (115%), caspase-3(75%)] levels in striatum as compared to the sham treatment.	Quinolinic Acid	14-29	tumor necrosis factor	Rattus norvegicus	250-259	
17304576-7	2007	Intrahippocampal TNF-alpha produced no effect alone but significantly reduced the neuronal loss produced by quinolinic acid.	Quinolinic Acid	108-123	tumor necrosis factor	Rattus norvegicus	17-26	
14725965-1	2004	We examined the expression of TNF-alpha within the substantia nigra pars reticulata (SNR) following intrastriatal injection of quinolinic acid (QA) and studied the effect of rolipram, a TNF-alpha-inhibitor, on the secondary neuronal damage.	Quinolinic Acid	127-142	tumor necrosis factor	Rattus norvegicus	30-39	
14725965-1	2004	We examined the expression of TNF-alpha within the substantia nigra pars reticulata (SNR) following intrastriatal injection of quinolinic acid (QA) and studied the effect of rolipram, a TNF-alpha-inhibitor, on the secondary neuronal damage.	Quinolinic Acid	144-146	tumor necrosis factor	Rattus norvegicus	30-39	
33078731-7	2020	Pro inflammatory mediators (tumor necrosis factor-alpha TNF-alpha and interleukin-1beta) were noted to increase in the hippocampus and striatum of QA-treated rats.	Quinolinic Acid	147-149	tumor necrosis factor	Rattus norvegicus	28-55	
33078731-7	2020	Pro inflammatory mediators (tumor necrosis factor-alpha TNF-alpha and interleukin-1beta) were noted to increase in the hippocampus and striatum of QA-treated rats.	Quinolinic Acid	147-149	tumor necrosis factor	Rattus norvegicus	56-65	
30130594-8	2018	QA-induced altered striatal oxido-nitrosative stress (superoxide dismutase, glutathione, malondialdehyde and nitric oxide), neuroinflammatory markers (TNF-alpha, IL"s and NF-kB mRNA) and apoptotic markers (Bax-Bcl-2, Caspase-3, and PPAR-gamma mRNA) were significantly attenuated by (p < 0.05) by naringin.	Quinolinic Acid	0-2	tumor necrosis factor	Rattus norvegicus	151-160	
21237233-4	2011	Intrastriatal administration of quinolinic acid significantly caused reduction in body weight and motor function (locomotor activity, rotarod performance and beam walk test), oxidative defense (as evidenced by increased lipid peroxidation, nitrite concentration and decreased endogenous antioxidant enzymes), alteration in mitochondrial enzyme complex (I, II and IV) activities, raised TNF-alpha level and striatal lesion volume as compared to sham treated animals.	Quinolinic Acid	32-47	tumor necrosis factor	Rattus norvegicus	386-395	
20696189-5	2011	Additionally, atorvastatin (10, 20 mg/kg), simvastatin (30 mg/kg) and fluvastatin (10 mg/kg) significantly decrease the TNF-alpha level and striatal lesion volume in quinolinic acid treated animals indicating their anti-inflammatory effects.	Quinolinic Acid	166-181	tumor necrosis factor	Rattus norvegicus	120-129