PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30023810-0 2018 Effects of Natural Polyphenols on the Expression of Drug Efflux Transporter P-Glycoprotein in Human Intestinal Cells. Polyphenols 19-30 ATP binding cassette subfamily B member 1 Homo sapiens 76-90 33191444-2 2020 This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells. Polyphenols 11-21 ATP binding cassette subfamily B member 1 Homo sapiens 67-81 33191444-2 2020 This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells. Polyphenols 11-21 ATP binding cassette subfamily B member 1 Homo sapiens 83-87 33669953-8 2021 More recently, natural polyphenols have emerged as a promising class of compounds to address P-gp linked MDR. Polyphenols 23-34 ATP binding cassette subfamily B member 1 Homo sapiens 93-97 30023810-2 2018 We previously reported that dietary polyphenols such as quercetin, curcumin, honokiol, magnolol, caffeic acid phenetyl ester (CAPE), xanthohumol, and anacardic acid inhibit P-glycoprotein-mediated drug transport. Polyphenols 36-47 ATP binding cassette subfamily B member 1 Homo sapiens 173-187 30023810-3 2018 In the present study, we investigated the effects of polyphenols on the expression of P-glycoprotein using human intestinal epithelial LS174T cells and a reporter plasmid expressing 10.2 kbp of the upstream regulatory region of MDR1. Polyphenols 53-64 ATP binding cassette subfamily B member 1 Homo sapiens 86-100 30023810-4 2018 Honokiol, magnolol, CAPE, xanthohumol, and anacardic acid activated the MDR1 promoter in LS174T cells, and the cellular uptake of rhodamine 123 and calcein-AM, fluorescent substrates of P-glycoprotein, decreased in polyphenol-treated LS174T cells. Polyphenols 215-225 ATP binding cassette subfamily B member 1 Homo sapiens 186-200 30023810-5 2018 These results suggest that dietary natural polyphenols can induce the drug efflux transporter P-glycoprotein and have the potential to promote food-drug interactions. Polyphenols 43-54 ATP binding cassette subfamily B member 1 Homo sapiens 94-108 24828476-6 2014 Furthermore, polyphenols may act synergistically due to their influence on efflux transporters such as p-glycoprotein. Polyphenols 13-24 ATP binding cassette subfamily B member 1 Homo sapiens 103-117 26463658-5 2016 Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family. Polyphenols 204-214 ATP binding cassette subfamily B member 1 Homo sapiens 117-131 27069731-2 2016 Polyphenols have variable potencies to interact, and hence alter the activities of various transporter proteins, many of them classified as anion transporting polypeptide-binding cassette transporters like multidrug resistance protein and p-glycoprotein. Polyphenols 0-11 ATP binding cassette subfamily B member 1 Homo sapiens 239-253 20438634-0 2010 Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. Polyphenols 108-119 ATP binding cassette subfamily B member 1 Homo sapiens 35-49 23967153-10 2013 Thus, GSP reverses P-gp associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-kappaB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing MDR by natural polyphenol supplement compounds. Polyphenols 257-267 ATP binding cassette subfamily B member 1 Homo sapiens 19-23 23967153-10 2013 Thus, GSP reverses P-gp associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-kappaB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing MDR by natural polyphenol supplement compounds. Polyphenols 257-267 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 34959345-0 2021 Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity. Polyphenols 11-22 ATP binding cassette subfamily B member 1 Homo sapiens 26-40 17637191-6 2007 The findings also suggested that the presence of a large number of galloyl groups in polyphenols strengthens the interaction with regulatory regions in P-gp. Polyphenols 85-96 ATP binding cassette subfamily B member 1 Homo sapiens 152-156 16394499-0 2006 Inhibitory effects of polyphenols on p-glycoprotein-mediated transport. Polyphenols 22-33 ATP binding cassette subfamily B member 1 Homo sapiens 37-51 16394499-2 2006 It has been revealed that flavonoids and other polyphenols inhibit P-gp activity. Polyphenols 47-58 ATP binding cassette subfamily B member 1 Homo sapiens 67-71 16394499-3 2006 Due to their inhibitory activities of polyphenols on P-gp function and their physiological safety, they are possible candidates for modulators of MDR. Polyphenols 38-49 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 16394499-5 2006 Determining the structure-activity relationships is also meaningful because the intake of dietary polyphenols may also alter drug pharmacokinetics and pharmacodynamics via inhibition of P-gp-mediated drug efflux in tissues such as the intestinal epithelium, blood-brain barrier, hepatocytes and renal tubular cells. Polyphenols 98-109 ATP binding cassette subfamily B member 1 Homo sapiens 186-190 11853888-0 2002 Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Polyphenols 76-87 ATP binding cassette subfamily B member 1 Homo sapiens 39-53 11853888-2 2002 In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells. Polyphenols 56-67 ATP binding cassette subfamily B member 1 Homo sapiens 124-138 11853888-2 2002 In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells. Polyphenols 56-67 ATP binding cassette subfamily B member 1 Homo sapiens 140-144 34959345-13 2021 Generally, our data demonstrate diverse interactions of the tested polyphenols with Pgp. Polyphenols 67-78 ATP binding cassette subfamily B member 1 Homo sapiens 84-87 34959345-14 2021 Our results also call attention to the potential risks of drug-drug interactions (DDIs) associated with the consumption of dietary polyphenols concurrently with chemotherapy treatment involving Pgp substrate/inhibitor drugs. Polyphenols 131-142 ATP binding cassette subfamily B member 1 Homo sapiens 194-197 11518657-13 2001 The multidrug resistance reversion mechanism of tea polyphenol seems to be its inhibition of the activity of P-glycoprotein. Polyphenols 52-62 ATP binding cassette subfamily B member 1 Homo sapiens 109-123 34959345-0 2021 Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity. Polyphenols 11-22 ATP binding cassette subfamily B member 1 Homo sapiens 42-47 34959345-5 2021 Previous studies have shown that certain polyphenols interact with human Pgp. Polyphenols 41-52 ATP binding cassette subfamily B member 1 Homo sapiens 73-76 34959345-6 2021 We tested the effect of 15 polyphenols of sour cherry origin on the basal and verapamil-stimulated ATPase activity of Pgp, calcein-AM and daunorubicin transport as well as on the conformation of Pgp using the conformation sensitive UIC2 mAb. Polyphenols 27-38 ATP binding cassette subfamily B member 1 Homo sapiens 118-121