PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22715906-0 2012 Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/beta-catenin signaling and FOXO1. Polyphenols 10-21 AKT serine/threonine kinase 1 Homo sapiens 76-79 21761876-1 2011 Polyphenols are known to induce vasodilatory function via activation of the redox-sensitive phosphatidylinositol-3 (PI3)/protein kinase B (Akt) pathway. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 139-142 23061908-0 2012 Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Polyphenols 6-17 AKT serine/threonine kinase 1 Homo sapiens 26-29 22252293-0 2012 Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition. Polyphenols 37-48 AKT serine/threonine kinase 1 Homo sapiens 149-152 22252293-7 2012 Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-kappaB), p38MAPK and Akt. Polyphenols 40-51 AKT serine/threonine kinase 1 Homo sapiens 198-201 20224869-5 2010 The polyphenol-induced NO formation is due to the redox-sensitive activation of the phosphatidylinositol3-kinase/Akt pathway leading to endothelial NO synthase (eNOS) activation subsequent to its phosphorylation on Ser 1177. Polyphenols 4-14 AKT serine/threonine kinase 1 Homo sapiens 113-116 21776820-0 2011 Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. Polyphenols 4-15 AKT serine/threonine kinase 1 Homo sapiens 107-110 21776820-7 2011 Thus, we can conclude that tea polyphenols inhibit the growth of cervical cancer cells by inducing apoptosis and regulating NF-kappaB and Akt. Polyphenols 31-42 AKT serine/threonine kinase 1 Homo sapiens 138-141 20224869-6 2010 Besides the phosphatidylinositol3-kinase/Akt pathway, polyphenols have also been shown to activate eNOS by increasing the intracellular free calcium concentration and by activating estrogen receptors in endothelial cells. Polyphenols 54-65 AKT serine/threonine kinase 1 Homo sapiens 41-44 25214119-0 2011 Antimetastatic activity of polyphenol-rich extract of Ecklonia cava through the inhibition of the Akt pathway in A549 human lung cancer cells. Polyphenols 27-37 AKT serine/threonine kinase 1 Homo sapiens 98-101 20117080-1 2010 Several rich sources of polyphenols stimulate the endothelial formation of nitric oxide (NO), a potent vasoprotecting factor, via the redox-sensitive activation of the PI3-kinase/Akt pathway leading to the phosphorylation of endothelial NO synthase (eNOS). Polyphenols 24-35 AKT serine/threonine kinase 1 Homo sapiens 179-182 16404708-4 2006 The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways. Polyphenols 109-120 AKT serine/threonine kinase 1 Homo sapiens 181-184 18059161-11 2007 Furthermore, AKT was found to be inhibited both at the RNA and protein level by polyphenol treatment. Polyphenols 80-90 AKT serine/threonine kinase 1 Homo sapiens 13-16 17539658-0 2007 Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. Polyphenols 4-14 AKT serine/threonine kinase 1 Homo sapiens 185-188 12931129-8 2003 These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS. Polyphenols 32-43 AKT serine/threonine kinase 1 Homo sapiens 104-107 15623569-0 2005 Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. Polyphenols 9-19 AKT serine/threonine kinase 1 Homo sapiens 115-118 15249422-0 2004 Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway. Polyphenols 9-20 AKT serine/threonine kinase 1 Homo sapiens 140-143 33794330-7 2021 The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa beta (NF-kappaB), mitogen activated protein kinases (MAPKs), Wnt/beta-catenin and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt) via selective actions on various components of the networks. Polyphenols 4-15 AKT serine/threonine kinase 1 Homo sapiens 261-264 11756245-0 2002 Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells. Polyphenols 10-21 AKT serine/threonine kinase 1 Homo sapiens 62-65 11756245-5 2002 Pre-treatment of PrEC and Du145 cells with doses as low as 20 microg/ml of a mixture of black tea polyphenols (BTP) substantially reduced IGF-I-mediated Akt phosphorylation. Polyphenols 98-109 AKT serine/threonine kinase 1 Homo sapiens 153-156 34744708-5 2021 We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, and MAPK and particularly those affecting the tumor suppressor p53 protein. Polyphenols 55-66 AKT serine/threonine kinase 1 Homo sapiens 154-157 33805467-0 2021 Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound. Polyphenols 105-115 AKT serine/threonine kinase 1 Homo sapiens 10-13 34896434-0 2022 Apple polyphenol phloretin complexed with ruthenium is capable of reprogramming the breast cancer microenvironment through modulation of PI3K/Akt/mTOR/VEGF pathways. Polyphenols 6-16 AKT serine/threonine kinase 1 Homo sapiens 142-145 35321703-5 2022 polyphenols (ILTPs) on human lung cancer cell line A549 (A549 cells) by regulating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 140-143 34044827-0 2021 The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway. Polyphenols 4-14 AKT serine/threonine kinase 1 Homo sapiens 108-111 32135183-0 2020 Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy. Polyphenols 45-56 AKT serine/threonine kinase 1 Homo sapiens 15-18 33884026-0 2021 Polyphenols from Broussonetia papyrifera Induce Apoptosis of HepG2 Cells via Inactivation of ERK and AKT Signaling Pathways. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 101-104 33641052-0 2021 New Insights into the Mechanisms of Polyphenol from Plum Fruit Inducing Apoptosis in Human Lung Cancer A549 Cells Via PI3K/AKT/FOXO1 Pathway. Polyphenols 36-46 AKT serine/threonine kinase 1 Homo sapiens 123-126 33443209-5 2020 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Polyphenols 103-113 AKT serine/threonine kinase 1 Homo sapiens 37-41 33443209-5 2020 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Polyphenols 103-113 AKT serine/threonine kinase 1 Homo sapiens 145-149 32135183-6 2020 One of the cellular pathways commonly affected by polyphenols is PI3K/Akt/mTOR pathway, which has far ranging effects on multiple key aspects of cellular growth, metabolism and death. Polyphenols 50-61 AKT serine/threonine kinase 1 Homo sapiens 70-73 32135183-7 2020 In this review article, evidence regarding the biology of polyphenols in cancer via PI3K/Akt/mTOR pathway is discussed and their application on cancer pathophysiology in various types of human malignancies is shown. Polyphenols 58-69 AKT serine/threonine kinase 1 Homo sapiens 89-92 32173528-4 2020 Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) directly binds to cell-surface 67LR and induces apoptosis through the protein kinase B (Akt)/endothelial nitric oxide synthase/nitric oxide/cyclic GMP (cGMP) axis. Polyphenols 10-20 AKT serine/threonine kinase 1 Homo sapiens 149-152 27610044-15 2016 Polyphenols prevented the stimulation of Akt phosphorylation, and in some cases also ERK phosphorylation. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 41-44 31089945-0 2019 Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt-p53-p21 pathways. Polyphenols 12-23 AKT serine/threonine kinase 1 Homo sapiens 117-120 28718669-8 2017 We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage. Polyphenols 21-31 AKT serine/threonine kinase 1 Homo sapiens 149-152 31059841-9 2019 Polyphenols activate intracellular pathways such as arachidonic acid dependent pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and epigenetic modulation, which regulate the host"s immune response. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 286-289 31195734-0 2019 Screening of Inhibitory Effects of Polyphenols on Akt-Phosphorylation in Endothelial Cells and Determination of Structure-Activity Features. Polyphenols 35-46 AKT serine/threonine kinase 1 Homo sapiens 50-53 31195734-4 2019 This work aimed to characterize effects of structurally different polyphenols on Akt-phosphorylation (pAkt) in endothelial cells (Ea.hy926) and to describe structure-activity features. Polyphenols 66-77 AKT serine/threonine kinase 1 Homo sapiens 81-84 31195734-8 2019 A strong positive and statistically significant correlation between the mean inhibitory effects of the tested polyphenols on both Akt-residues Ser473 and Thr308 (r = 0.9478, p = 0.0003) was determined by immunoblotting. Polyphenols 110-121 AKT serine/threonine kinase 1 Homo sapiens 130-133 31195734-12 2019 The suggested molecular mode of action of polyphenols involving Akt-inhibition contributes to understanding their effects on the cellular level. Polyphenols 42-53 AKT serine/threonine kinase 1 Homo sapiens 64-67 29088809-0 2017 Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-kappaB signaling pathway. Polyphenols 55-66 AKT serine/threonine kinase 1 Homo sapiens 109-112 28718669-9 2017 Our data demonstrated that fruit peel polyphenols suppressed breast cancer cell growth through increased intracellular oxidative stress and the activation of p38 MAPK and de-activation of the Erk 1/2 and Akt signaling pathways. Polyphenols 38-49 AKT serine/threonine kinase 1 Homo sapiens 204-207 24251781-7 2014 This review provides a systematic view that polyphenols target multiple inflammatory components and reinforce anti-inflammatory mechanisms by antioxidant potentials, AMPK activation, PI3K/AkT inhibition, IKK/JNK inhibition, mTORC1 inhibition, JAK/STAT inhibition, TLR suppression, and ACE inhibition. Polyphenols 44-55 AKT serine/threonine kinase 1 Homo sapiens 188-191 25337568-0 2014 Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 128-131 23222814-6 2013 However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1). Polyphenols 46-56 AKT serine/threonine kinase 1 Homo sapiens 179-183 24021570-0 2013 Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells. Polyphenols 0-11 AKT serine/threonine kinase 1 Homo sapiens 104-107 23963285-1 2013 Red wine polyphenols (RWP) induce nitric oxide (NO) and endothelium-derived hyperpolarization (EDH)-mediated coronary vasodilatation involving the redox-sensitive PI3-kinase/Akt-dependent pathway in the endothelium. Polyphenols 9-20 AKT serine/threonine kinase 1 Homo sapiens 174-177