PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34257824-5 2021 Dietary intake of flavonoids, a C15 group of polyphenols, is known to inhibit cancer progression and assist DNA repair through p53-mediated mechanisms in human cells via their antioxidant activities. Polyphenols 45-56 tumor protein p53 Homo sapiens 127-130 34744708-5 2021 We describe the protein modifications induced by these polyphenols and their effect on the central elements of several signaling pathways including PI3K, Akt, mTOR, RAS, and MAPK and particularly those affecting the tumor suppressor p53 protein. Polyphenols 55-66 tumor protein p53 Homo sapiens 233-236 34744708-6 2021 Modifications of p53 induced by these polyphenols regulate p53 gene expression and protein levels and posttranslational modifications such as phosphorylation, acetylation, and ubiquitination that influence stability, subcellular location, activation of new transcriptional targets, and the role of p53 in response to DNA damage, apoptosis control, cell- cycle regulation, senescence, and cell fate. Polyphenols 38-49 tumor protein p53 Homo sapiens 17-20 34744708-6 2021 Modifications of p53 induced by these polyphenols regulate p53 gene expression and protein levels and posttranslational modifications such as phosphorylation, acetylation, and ubiquitination that influence stability, subcellular location, activation of new transcriptional targets, and the role of p53 in response to DNA damage, apoptosis control, cell- cycle regulation, senescence, and cell fate. Polyphenols 38-49 tumor protein p53 Homo sapiens 59-62 34959709-0 2021 Mulberry Leaf Polyphenol Extract and Rutin Induces Autophagy Regulated by p53 in Human Hepatoma HepG2 Cells. Polyphenols 14-24 tumor protein p53 Homo sapiens 74-77 34959709-3 2021 We previously revealed that apoptosis was mediated in p53-negative Hep3B cells, and mulberry leaf polyphenol extract (MLPE) induced autophagy in p53-transfected Hep3B cells. Polyphenols 98-108 tumor protein p53 Homo sapiens 145-148 34257824-7 2021 Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Polyphenols 6-17 tumor protein p53 Homo sapiens 49-52 34257824-7 2021 Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Polyphenols 6-17 tumor protein p53 Homo sapiens 106-109 34257824-7 2021 Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Polyphenols 6-17 tumor protein p53 Homo sapiens 178-181 31004736-0 2020 Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions. Polyphenols 23-34 tumor protein p53 Homo sapiens 49-52 33918387-0 2021 Distinct Classes of Flavonoids and Epigallocatechin Gallate, Polyphenol Affects an Oncogenic Mutant p53 Protein, Cell Growth and Invasion in a TNBC Breast Cancer Cell Line. Polyphenols 61-71 tumor protein p53 Homo sapiens 100-103 33573023-2 2021 The purpose of this study was to elucidate the role of JNK on the anticancer effects of the Korean plant Artemisia annua L. (pKAL) polyphenols in p53 wild-type HCT116 human colorectal cancer cells. Polyphenols 131-142 tumor protein p53 Homo sapiens 146-149 33297377-0 2020 p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells. Polyphenols 32-43 tumor protein p53 Homo sapiens 0-3 33297377-0 2020 p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells. Polyphenols 32-43 tumor protein p53 Homo sapiens 87-90 33297377-2 2020 The aim of this study was to investigate the role of p53 on the anticancer effect of polyphenols isolated from Korean Artemisia annua L. (pKAL) in HCT116 human colorectal cancer cells. Polyphenols 85-96 tumor protein p53 Homo sapiens 53-56 31974389-3 2020 We reported that both polyphenols show antioxidant and oto-protective activity in the cochlea by up-regulating Nrf-2/HO-1 pathway and downregulating p53 phosphorylation. Polyphenols 22-33 tumor protein p53 Homo sapiens 149-152 31004736-1 2020 The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Polyphenols 26-37 tumor protein p53 Homo sapiens 117-133 31004736-1 2020 The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Polyphenols 26-37 tumor protein p53 Homo sapiens 135-138 31004736-3 2020 A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. Polyphenols 12-23 tumor protein p53 Homo sapiens 80-83 31004736-4 2020 The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression. Polyphenols 125-136 tumor protein p53 Homo sapiens 170-173 25100434-5 2014 By RT-PCR and western blot assays, Kuding tea polyphenol significantly induced apoptosis in BcaCD885 cancer cells (p < 0.05) by upregulating caspase-3, caspase-8, caspase-9, Fas/FasL, Bax, p53, p21, E2F1, p73 and downregulating Bcl-2, Bcl-xL, HIAP-1, and HIAP-2 mRNA and protein expressions. Polyphenols 46-56 tumor protein p53 Homo sapiens 192-195 29681859-6 2018 All studied polyphenols evoked anti-proliferative activity, accompanied by increased PRODH/POX, P53, active caspases-3 and -9 expressions and decreased collagen biosynthesis, prolidase activity and proline concentration in CAL-27 cells. Polyphenols 12-23 tumor protein p53 Homo sapiens 96-125 31974389-9 2020 Thanks to their biphasic activity of antioxidant in normal cells undergoing stressful conditions and pro-oxidant in cancer cells, these polyphenols probably engage an interplay among the key factors Nrf-2, NF-kappaB, STAT-3 and p53. Polyphenols 136-147 tumor protein p53 Homo sapiens 228-231 31089945-0 2019 Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt-p53-p21 pathways. Polyphenols 12-23 tumor protein p53 Homo sapiens 121-124 31353662-0 2019 Protective effects of hawthorn (Crataegus pinnatifida) polyphenol extract against UVB-induced skin damage by modulating the p53 mitochondrial pathway in vitro and in vivo. Polyphenols 55-65 tumor protein p53 Homo sapiens 124-127 31353662-6 2019 Treatment with HPE or its polyphenol components inhibited the UVB-induced damage by removing an excess of reactive oxygen species (ROS), reducing DNA damage and p53 activation, regulating the protein expression of B-cell lymphoma 2 family members toward antiapoptotic ratios, and reducing caspase activation. Polyphenols 26-36 tumor protein p53 Homo sapiens 161-164 26231140-4 2015 In the resting neutrophils resveratrol and to lesser extent other polyphenols increased DNA damage and increased the level of p53. Polyphenols 66-77 tumor protein p53 Homo sapiens 126-129 24839007-0 2014 Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells. Polyphenols 46-56 tumor protein p53 Homo sapiens 80-83 24839007-1 2014 Green tea polyphenol (GTP) is one of the most promising chemopreventive agent for cancer; it can inhibit cancer cell proliferation and induce apoptosis through p53-dependent cell signaling pathways. Polyphenols 10-20 tumor protein p53 Homo sapiens 160-163 23285096-0 2012 Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. Polyphenols 10-21 tumor protein p53 Homo sapiens 29-32 27481281-0 2013 Molecular Dynamics Investigation on the Inhibition of MDM2-p53 Interaction by Polyphenols. Polyphenols 78-89 tumor protein p53 Homo sapiens 59-62 22676643-0 2012 Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell. Polyphenols 14-24 tumor protein p53 Homo sapiens 149-152 22676643-3 2012 In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells. Polyphenols 66-76 tumor protein p53 Homo sapiens 118-121 22676643-3 2012 In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells. Polyphenols 66-76 tumor protein p53 Homo sapiens 143-146 22676643-3 2012 In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells. Polyphenols 66-76 tumor protein p53 Homo sapiens 143-146 22676643-3 2012 In this study, we aimed to detect the effect of the mulberry leaf polyphenol extract (MLPE) on inducing cell death in p53-negative (Hep3B) and p53-positive (Hep3B with transfected p53) hepatocellular carcinoma cells and also to clarify the role of p53 in MLPE-treated cells. Polyphenols 66-76 tumor protein p53 Homo sapiens 143-146 22552582-0 2012 Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. Polyphenols 10-21 tumor protein p53 Homo sapiens 31-34 22552582-3 2012 In this study, we demonstrate that green tea polyphenols (GTPs) and their major constituent, (-) epigallocatechin-3-gallate (EGCG), activate p53 through acetylation at the Lys373 and Lys382 residues by inhibiting class I HDACs in LNCaP human prostate cancer cells. Polyphenols 45-56 tumor protein p53 Homo sapiens 141-144 25337568-0 2014 Polyphenols Isolated from Allium cepa L. Induces Apoptosis by Induction of p53 and Suppression of Bcl-2 through Inhibiting PI3K/Akt Signaling Pathway in AGS Human Cancer Cells. Polyphenols 0-11 tumor protein p53 Homo sapiens 75-78 22202062-2 2012 Regulation of anti-tumor p53 functions by dietary plant polyphenols particularly black tea and its active component theaflavins has gained immense recognition from the point of view of both efficacy and safety. Polyphenols 56-67 tumor protein p53 Homo sapiens 25-28 23285096-0 2012 Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. Polyphenols 10-21 tumor protein p53 Homo sapiens 47-50 20070102-0 2010 Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase. Polyphenols 0-10 tumor protein p53 Homo sapiens 120-123 21196432-5 2011 Both strategies could use tyrosinase-mediated activation of quercetin, a dietary polyphenol that induces the expression of p53 and modulates reactive oxygen species. Polyphenols 81-91 tumor protein p53 Homo sapiens 123-126 19406223-0 2009 Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549. Polyphenols 58-69 tumor protein p53 Homo sapiens 93-96 17499812-3 2007 In the present study, we report that black tea polyphenol, Theaflavins (TF)-induced apoptosis in human prostate carcinoma, LNCaP cells is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-kappa B activity, causing a change in the ratio of pro-and antiapoptotic proteins leading to apoptosis. Polyphenols 47-57 tumor protein p53 Homo sapiens 204-207 11522280-0 2001 Do wine polyphenols modulate p53 gene expression in human cancer cell lines? Polyphenols 8-19 tumor protein p53 Homo sapiens 29-32 11522280-8 2001 CONCLUSIONS: The observed p53 concentration changes upon stimulation by polyphenols are relatively small, do not follow a uniform pattern in the four cell lines tested, and do not exhibit a dose-response effect. Polyphenols 72-83 tumor protein p53 Homo sapiens 26-29