PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18813848-0 2008 Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. Polyphenols 44-55 fatty acid synthase Homo sapiens 84-103 22676643-0 2012 Mulberry leaf polyphenol extract induced apoptosis involving regulation of adenosine monophosphate-activated protein kinase/fatty acid synthase in a p53-negative hepatocellular carcinoma cell. Polyphenols 14-24 fatty acid synthase Homo sapiens 124-143 22753716-8 2012 Our studies in vitro demonstrated that FAS might also be a molecular target for the antiproliferative activity of olive oil polyphenols in a metabolically defined subset of patients with colon cancer. Polyphenols 124-135 fatty acid synthase Homo sapiens 39-42 21437031-0 2011 Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Polyphenols 21-32 fatty acid synthase Homo sapiens 36-55 20008854-2 2009 The natural polyphenol (-)-epigallocatechin-3-gallate blocks in vitro FASN activity and leads to apoptosis in breast cancer cells without any effects on carnitine palmitoyltransferase-1 (CPT-1) activity, and in vivo, does not decrease body weight. Polyphenols 12-22 fatty acid synthase Homo sapiens 70-74 16611078-0 2006 Inhibition of fatty acid synthase by polyphenols. Polyphenols 37-48 fatty acid synthase Homo sapiens 14-33 18482975-4 2008 Polyphenols substantially prevent the impairment in phosphorylation of AMPK and its downstream target, ACC (acetyl-CoA carboxylase), elevation in expression of FAS (fatty acid synthase), and lipid accumulation in human HepG2 hepatocytes exposed to high glucose. Polyphenols 0-11 fatty acid synthase Homo sapiens 160-163 18482975-4 2008 Polyphenols substantially prevent the impairment in phosphorylation of AMPK and its downstream target, ACC (acetyl-CoA carboxylase), elevation in expression of FAS (fatty acid synthase), and lipid accumulation in human HepG2 hepatocytes exposed to high glucose. Polyphenols 0-11 fatty acid synthase Homo sapiens 165-184 16611078-15 2006 From these results, a common model for polyphenol inhibitor of FAS is conceived. Polyphenols 39-49 fatty acid synthase Homo sapiens 63-66 17539658-0 2007 Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. Polyphenols 4-14 fatty acid synthase Homo sapiens 81-100 16404708-4 2006 The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways. Polyphenols 109-120 fatty acid synthase Homo sapiens 65-84 16611078-3 2006 It is found that tea polyphenols inhibit FAS in both reversible and irreversible manners. Polyphenols 21-32 fatty acid synthase Homo sapiens 41-44 16428296-0 2005 Structure-activity relationship of polyphenols that inhibit fatty acid synthase. Polyphenols 35-46 fatty acid synthase Homo sapiens 60-79 16428296-2 2005 Here, using nordihydroguaiaretic acid (NDGA), with two phenyl rings connected by a four-carbon chain, as a representative, the structural basis for the inhibition of animal fatty acid synthase (FAS) by polyphenols was investigated. Polyphenols 202-213 fatty acid synthase Homo sapiens 173-192 16428296-2 2005 Here, using nordihydroguaiaretic acid (NDGA), with two phenyl rings connected by a four-carbon chain, as a representative, the structural basis for the inhibition of animal fatty acid synthase (FAS) by polyphenols was investigated. Polyphenols 202-213 fatty acid synthase Homo sapiens 194-197 16428296-8 2005 A structure-activity relationship study indicated that a biphenyl core exists in all FAS polyphenol inhibitors. Polyphenols 89-99 fatty acid synthase Homo sapiens 85-88 16428296-9 2005 Thus, we propose a common model possibly shared by all FAS polyphenol inhibitors. Polyphenols 59-69 fatty acid synthase Homo sapiens 55-58 29751678-1 2018 (-)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. Polyphenols 51-61 fatty acid synthase Homo sapiens 156-175 29751678-1 2018 (-)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. Polyphenols 51-61 fatty acid synthase Homo sapiens 177-181 12931129-0 2003 Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Polyphenols 79-90 fatty acid synthase Homo sapiens 15-34 12931129-5 2003 The expression of FAS was also suppressed by the tea polyphenol (-)-epigallocatechin 3-gallate (EGCG), theaflavin (TF-1), TF-2 and theaflavin 3,3"-digallate(TF-3) at both protein and mRNA levels that may lead to the inhibition of cell lipogenesis and proliferation. Polyphenols 53-63 fatty acid synthase Homo sapiens 18-21 12931129-8 2003 These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS. Polyphenols 32-43 fatty acid synthase Homo sapiens 53-56 12931129-8 2003 These findings suggest that tea polyphenols suppress FAS expression by downregulating EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway, and tea and tea polyphenols might induce hypolipidemic and antiproliferative effects by suppressing FAS. Polyphenols 32-43 fatty acid synthase Homo sapiens 242-245