PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24251781-8 2014 As a result, polyphenols readily lead to NFkappaB, AP-1, HIF, and STAT inactivations with reduced proinflammatory mediator generation. Polyphenols 13-24 nuclear factor kappa B subunit 1 Homo sapiens 41-49 29616249-5 2018 Polyphenols, which are powerful phytochemicals, act as direct and indirect antioxidants, reduce the inflammatory response, improve proteostasis and mitochondrial biogenesis, modulate many cell signaling pathways, have a major role in cytoprotection, are Nrf2/ARE activators, down-regulate the NFkappaB system, promote anticancer potential, and prevent cell senescence. Polyphenols 0-11 nuclear factor kappa B subunit 1 Homo sapiens 293-301 24246683-3 2014 Hydroxytyrosol is an orally bioavailable polyphenol, obtained from olives, which inhibits NF-kappabeta activity and has elicited promising efficacy signals in several inflammatory diseases. Polyphenols 41-51 nuclear factor kappa B subunit 1 Homo sapiens 90-102 28432554-3 2017 However, in the presence of epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, BEAS-2B cells resisted LPS-induced apoptosis and restored the expression of GRP and its downstream effectors such as epidermal growth factor receptor and NF-kappaB, as analysed by immunoblotting and qPCR. Polyphenols 65-75 nuclear factor kappa B subunit 1 Homo sapiens 244-253 29192437-6 2017 In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food. Polyphenols 97-108 nuclear factor kappa B subunit 1 Homo sapiens 192-201 29088809-0 2017 Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-kappaB signaling pathway. Polyphenols 55-66 nuclear factor kappa B subunit 1 Homo sapiens 113-122 28235660-10 2017 Curcumin, another polyphenol, can suppress overexpression of inflammatory mediators via inhibiting the TLR4-MAPK/NF-kappaB pathway. Polyphenols 18-28 nuclear factor kappa B subunit 1 Homo sapiens 113-122 26538333-0 2016 Extractable and non-extractable polyphenols from blueberries modulate LPS-induced expression of iNOS and COX-2 in RAW264.7 macrophages via the NF-kappaB signalling pathway. Polyphenols 32-43 nuclear factor kappa B subunit 1 Homo sapiens 143-152 26878794-2 2016 It is well known that bioactive food compounds such as polyphenols may exert their protection by modulating inflammatory pathways regulated through nuclear factor-kappa B (NF-kappaB) signaling. Polyphenols 55-66 nuclear factor kappa B subunit 1 Homo sapiens 148-170 26878794-2 2016 It is well known that bioactive food compounds such as polyphenols may exert their protection by modulating inflammatory pathways regulated through nuclear factor-kappa B (NF-kappaB) signaling. Polyphenols 55-66 nuclear factor kappa B subunit 1 Homo sapiens 172-181 26529010-7 2015 In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and beta-catenin/T cell factor (Tcf)). Polyphenols 28-38 nuclear factor kappa B subunit 1 Homo sapiens 283-292 21776820-0 2011 Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. Polyphenols 4-15 nuclear factor kappa B subunit 1 Homo sapiens 81-102 21895782-8 2012 Thus, polyphenol-rich GSGM meal-based feed additives may be useful for the inhibition or prevention of inflammatory processes in the intestine of livestock animals, in particular during states with inappropriate NF-kappaB activation in the intestinal tissue, such as the weaning phase. Polyphenols 6-16 nuclear factor kappa B subunit 1 Homo sapiens 212-221 22252293-0 2012 Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition. Polyphenols 37-48 nuclear factor kappa B subunit 1 Homo sapiens 126-135 22252293-7 2012 Biochemical analysis showed that quince polyphenols extract inhibited the LPS-mediated activation of three major cellular pro-inflammatory effectors, nuclear factor-kappa B (NF-kappaB), p38MAPK and Akt. Polyphenols 40-51 nuclear factor kappa B subunit 1 Homo sapiens 174-183 21756928-0 2011 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFkappaB and AhR and EGFR-ERK pathway. Polyphenols 6-17 nuclear factor kappa B subunit 1 Homo sapiens 144-152 21776820-7 2011 Thus, we can conclude that tea polyphenols inhibit the growth of cervical cancer cells by inducing apoptosis and regulating NF-kappaB and Akt. Polyphenols 31-42 nuclear factor kappa B subunit 1 Homo sapiens 124-133 20584749-0 2010 Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target. Polyphenols 29-39 nuclear factor kappa B subunit 1 Homo sapiens 72-83 16354769-11 2006 Results suggest that signaling through p38 mitogen-activated protein kinase, NF-kappaB, and Nrf2 as well as other unidentified molecules is involved in HO-1 induction by hemin and both polyphenols, but cell-specific factors also play a role, particularly with respect to EGCG. Polyphenols 185-196 nuclear factor kappa B subunit 1 Homo sapiens 77-86 17499812-3 2007 In the present study, we report that black tea polyphenol, Theaflavins (TF)-induced apoptosis in human prostate carcinoma, LNCaP cells is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-kappa B activity, causing a change in the ratio of pro-and antiapoptotic proteins leading to apoptosis. Polyphenols 47-57 nuclear factor kappa B subunit 1 Homo sapiens 231-241 16862172-0 2007 Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells. Polyphenols 10-20 nuclear factor kappa B subunit 1 Homo sapiens 72-81 16354769-0 2006 Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Polyphenols 142-153 nuclear factor kappa B subunit 1 Homo sapiens 37-58 18327875-6 2008 Curcumin is a polyphenol present in the spice turmeric, which can directly scavenge free radicals such as superoxide anion and nitric oxide and modulate important signaling pathways mediated via NF-kappaB and mitogen-activated protein kinase pathways. Polyphenols 14-24 nuclear factor kappa B subunit 1 Homo sapiens 195-204 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. Polyphenols 54-65 nuclear factor kappa B subunit 1 Homo sapiens 93-102 16970955-9 2007 CONCLUSION: Consumption of moderate amounts of alcoholic drinks containing polyphenols decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a fat-enriched diet. Polyphenols 75-86 nuclear factor kappa B subunit 1 Homo sapiens 97-106 17189836-0 2007 Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? Polyphenols 21-32 nuclear factor kappa B subunit 1 Homo sapiens 73-81 10470285-7 1999 Thus, EGCG and other tea polyphenols may interact with various transcription factors, in addition to AP-1 and NF-kappa B, in nuclei of various cells, resulting in inhibition of TNF-alpha gene expression and TNF-alpha release. Polyphenols 25-36 nuclear factor kappa B subunit 1 Homo sapiens 110-120 15652768-1 2005 This study investigated for the first time the effects of the cis isomer of RESV (c-RESV), a polyphenol present in red wine, on an array of genes whose expression is controlled by nuclear factor kappa B (NF-kappaB) and whose transcriptional activation is critical in a number of pathologies (including some cardiovascular diseases). Polyphenols 93-103 nuclear factor kappa B subunit 1 Homo sapiens 180-202 15652768-1 2005 This study investigated for the first time the effects of the cis isomer of RESV (c-RESV), a polyphenol present in red wine, on an array of genes whose expression is controlled by nuclear factor kappa B (NF-kappaB) and whose transcriptional activation is critical in a number of pathologies (including some cardiovascular diseases). Polyphenols 93-103 nuclear factor kappa B subunit 1 Homo sapiens 204-213 34863710-0 2022 The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-kappaB pathway exert anti-inflammatory activity in ischemic stroke. Polyphenols 12-25 nuclear factor kappa B subunit 1 Homo sapiens 75-84 33794330-7 2021 The polyphenols are able to modulate several inflammation-associated cell signaling pathways, namely nuclear factor-kappa beta (NF-kappaB), mitogen activated protein kinases (MAPKs), Wnt/beta-catenin and phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt) via selective actions on various components of the networks. Polyphenols 4-15 nuclear factor kappa B subunit 1 Homo sapiens 128-137 33808148-4 2021 Indeed, it was found in keratinocytes that carotenoids and polyphenols inhibit UVB-induced NFkappaB activity and release of cytokine IL-6. Polyphenols 59-70 nuclear factor kappa B subunit 1 Homo sapiens 91-99 34863710-11 2022 Thus, this review focuses on the anti-inflammatory properties of dietary (poly)phenols and discusses their effects on the polarization of microglia through modulating TLR4/NF-kappaB signaling pathway in the ischemic stroke. Polyphenols 74-86 nuclear factor kappa B subunit 1 Homo sapiens 172-181 34770980-5 2021 Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-kappaB), and c-Jun N-terminal kinases (JNK)). Polyphenols 0-11 nuclear factor kappa B subunit 1 Homo sapiens 264-273 34419542-3 2021 The hydrophobic polyphenol curcumin is shown to inhibit NF-kappaB and hence CR. Polyphenols 16-26 nuclear factor kappa B subunit 1 Homo sapiens 56-65 34944489-8 2021 Although EGCG did not reduce (e)Abeta42, the polyphenol reversed Ca2+ influx dysregulation as a response to acetylcholine (ACh) stimuli in PSEN1 E280A ChLNs, inhibited the activation of transcription factor NF-kappaB, and reduced the secretion of pro-inflammatory IL-6 in wild-type astrocyte-like cells (ALCs) when exposed to mutant ChLNs culture supernatant. Polyphenols 45-55 nuclear factor kappa B subunit 1 Homo sapiens 207-216 34371836-7 2021 We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Polyphenols 83-93 nuclear factor kappa B subunit 1 Homo sapiens 126-131 34361774-2 2021 The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-kappaB and PPAR-gamma receptor. Polyphenols 9-19 nuclear factor kappa B subunit 1 Homo sapiens 280-289 35218127-9 2022 Although polyphenols reportedly inhibit the NF-kappaB signaling pathway, phosphorylation of NF-kappaB p65 was observed. Polyphenols 9-20 nuclear factor kappa B subunit 1 Homo sapiens 44-53 34069133-0 2021 Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-kappaB Dependent and Independent Pathways: Protective Effects of Polyphenols. Polyphenols 163-174 nuclear factor kappa B subunit 1 Homo sapiens 95-104 34069133-10 2021 These data indicated that polyphenols prevented PM-induced migration and cytokine secretion via blocking the ROS-dependent NF-kappaB signaling pathway in VSMCs. Polyphenols 26-37 nuclear factor kappa B subunit 1 Homo sapiens 123-132 35104489-7 2022 Nutraceuticals belonging to the chemical category polyphenols, alkaloids, terpenoids, flavonoids, tannins have the potential to combat the NF-kappaB pathway. Polyphenols 50-61 nuclear factor kappa B subunit 1 Homo sapiens 139-148 35630763-8 2022 Moreover, these polyphenols can manage the inflammation via various mechanisms, in particular the inhibition of the transcriptional factor Nf-kappaB. Polyphenols 16-27 nuclear factor kappa B subunit 1 Homo sapiens 139-148 34525916-6 2022 Besides, polyphenols downregulate NF-kappaB, suppressing the pro-inflammatory state developed in NAFLD and upregulate liver Nrf2, increasing the cellular antioxidant potential. Polyphenols 9-20 nuclear factor kappa B subunit 1 Homo sapiens 34-43 34978320-6 2022 Ten preclinical studies have found that prunes and/or their polyphenol extracts decrease malondialdehyde and nitric oxide secretion, increase antioxidant enzyme expression, or suppress NF-kappaB activation and pro-inflammatory cytokine production. Polyphenols 60-70 nuclear factor kappa B subunit 1 Homo sapiens 185-194 35204100-7 2022 Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-kappaB pathway, resulting in the suppression of osteoclastogenesis. Polyphenols 32-43 nuclear factor kappa B subunit 1 Homo sapiens 182-191 35204100-7 2022 Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-kappaB pathway, resulting in the suppression of osteoclastogenesis. Polyphenols 48-58 nuclear factor kappa B subunit 1 Homo sapiens 182-191 33530554-6 2021 Moreover, polyphenols could modulate microbiota composition, inhibit the NF-kappaB pathway, lower IL-6, and upregulate antioxidant enzymes. Polyphenols 10-21 nuclear factor kappa B subunit 1 Homo sapiens 73-82 33673390-10 2021 We note that Mediterranean diet (MedDiet) dietary polyphenols can de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and NF-kappaB-mediated oxidative stress, and metabolic inflammation. Polyphenols 50-61 nuclear factor kappa B subunit 1 Homo sapiens 148-157 31974389-9 2020 Thanks to their biphasic activity of antioxidant in normal cells undergoing stressful conditions and pro-oxidant in cancer cells, these polyphenols probably engage an interplay among the key factors Nrf-2, NF-kappaB, STAT-3 and p53. Polyphenols 136-147 nuclear factor kappa B subunit 1 Homo sapiens 206-215 33372886-8 2021 Polyphenols are endowed with anti-oxidant and anti-inflammatory activity in view of their property to inhibit NF-kappaB activation, to induce the anti-inflammatory T regulatory cells and to normalize the intestinal microbiota. Polyphenols 0-11 nuclear factor kappa B subunit 1 Homo sapiens 110-119 33425912-2 2020 We previously demonstrated that green tea polyphenol EGCG had potent anti-tumor effect in bladder cancer via down regulation of NF-kappaB. Polyphenols 42-52 nuclear factor kappa B subunit 1 Homo sapiens 128-137 31823227-0 2020 NF-kappaB-Mediated Neuroinflammation in Parkinson"s Disease and Potential Therapeutic Effect of Polyphenols. Polyphenols 96-107 nuclear factor kappa B subunit 1 Homo sapiens 0-9 31823227-9 2020 In this aspect, this review highlights the role of NF-kappaB and the possible therapeutic roles of polyphenols in NF-kappaB-mediated neuroinflammation in PD. Polyphenols 99-110 nuclear factor kappa B subunit 1 Homo sapiens 114-123 33213314-0 2021 Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-kappaB to Halt Alzheimer"s Disease. Polyphenols 36-47 nuclear factor kappa B subunit 1 Homo sapiens 62-71 33213314-9 2021 This review represents the anti-neuroinflammatory potential of polyphenols as inhibitors of NF-kappaB to combat AD pathogenesis. Polyphenols 63-74 nuclear factor kappa B subunit 1 Homo sapiens 92-101 33038311-2 2020 We analyzed and discovered a novel mechanism by which epigallocatechin gallate (EGCG), the most abundant polyphenol in tea and a putative health-promoting constituent, inhibits activation of the nuclear transcription factor NF-kappaB, which mediates inflammatory responses to cytokines and other agents. Polyphenols 105-115 nuclear factor kappa B subunit 1 Homo sapiens 224-233 32655263-6 2020 We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factor kappaB (NF-kappaB) and JAK/STAT signaling pathways. Polyphenols 14-25 nuclear factor kappa B subunit 1 Homo sapiens 154-163 32490857-6 2020 The polyphenols and their microbial metabolites alleviate IBD through reduction of oxidative stress, inhibition of inflammatory cytokines secretion (TNF-alpha, IL-6, IL-8, and IL-1beta), suppression of NF-kappaB, upregulation of Nrf2, gut barrier protection, and modulation of immune function. Polyphenols 4-15 nuclear factor kappa B subunit 1 Homo sapiens 202-211 31512490-0 2020 Targeting NF-kappaB signaling pathway in cancer by dietary polyphenols. Polyphenols 59-70 nuclear factor kappa B subunit 1 Homo sapiens 10-19 31512490-5 2020 Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-kappaB signaling pathway. Polyphenols 0-11 nuclear factor kappa B subunit 1 Homo sapiens 122-131 31512490-7 2020 Through inhibition of NF-kappaB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. Polyphenols 33-44 nuclear factor kappa B subunit 1 Homo sapiens 22-31 31512490-8 2020 This review highlights the anticancer effects of polyphenols on the basis of NF-kappaB signaling pathway regulation. Polyphenols 49-60 nuclear factor kappa B subunit 1 Homo sapiens 77-86 31773117-2 2019 Curcumin, a dietary polyphenol isolated from the rhizome of turmeric, has been found to have therapeutic benefits in chronic obstructive pulmonary disease (COPD) via inhibiting NF-kappaB. Polyphenols 20-30 nuclear factor kappa B subunit 1 Homo sapiens 177-186 31059841-9 2019 Polyphenols activate intracellular pathways such as arachidonic acid dependent pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and epigenetic modulation, which regulate the host"s immune response. Polyphenols 0-11 nuclear factor kappa B subunit 1 Homo sapiens 152-161 31393642-0 2019 Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-kappaB Pathway. Polyphenols 18-29 nuclear factor kappa B subunit 1 Homo sapiens 122-131 31134076-7 2019 Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages. Polyphenols 14-25 nuclear factor kappa B subunit 1 Homo sapiens 93-102 31134076-7 2019 Further, some polyphenols can suppress overexpression of inflammatory mediators through TLR4/NF-kappaB/STAT signaling intervention, while others can reduce neuronal apoptosis via modulating the TLR4/MyD88/NF-kappaB-pathway in microglia/macrophages. Polyphenols 14-25 nuclear factor kappa B subunit 1 Homo sapiens 205-214 31013659-7 2019 The main RA factors modified by polyphenols are mitogen-activated protein kinase (MAPK), interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) and c-Jun N-terminal kinases (JNK). Polyphenols 32-43 nuclear factor kappa B subunit 1 Homo sapiens 230-239