PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33375450-6 2020 The results show that long-term intake of polyphenol-enriched diet improves memory and learning, correlating with restoration of brain monoaminergic neurotransmitters and hippocampal SIRT1 levels in aged rats. Polyphenols 42-52 sirtuin 1 Rattus norvegicus 183-188 28751004-8 2017 The translocation of GLUT4, phosphorylation of AMPK and the expression of SIRT1 and PGC-1alpha which were reduced in insulin resistant cells, were increased upon treatment with polyphenols. Polyphenols 177-188 sirtuin 1 Rattus norvegicus 74-79 32311492-5 2020 Stilbenoids are bioactive polyphenols and earlier studies have shown that imine stilbene exert cardioprotective and anti aging effects by acting as modulators of Sirt1. Polyphenols 26-37 sirtuin 1 Rattus norvegicus 162-167 31281594-8 2019 Polyphenols tend to fine-tune SIRT1 expression towards normal in the liver of intoxicated rats in both acute and subchronic studies. Polyphenols 0-11 sirtuin 1 Rattus norvegicus 30-35 31281594-10 2019 The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols. Polyphenols 80-91 sirtuin 1 Rattus norvegicus 26-31 31281594-10 2019 The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols. Polyphenols 80-91 sirtuin 1 Rattus norvegicus 98-103 31281594-10 2019 The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols. Polyphenols 80-91 sirtuin 1 Rattus norvegicus 98-103 31281594-10 2019 The catalytic activity of SIRT1 is important in the hepatoprotective effects of polyphenols where SIRT1 inhibitors block and the allosteric SIRT1 activators mimic the hepatoprotective effects of polyphenols. Polyphenols 195-206 sirtuin 1 Rattus norvegicus 26-31 29242624-3 2017 SIRT1 activators, including plant polyphenols such as resveratrol, improve insulin sensitivity in skeletal muscle tissue. Polyphenols 34-45 sirtuin 1 Rattus norvegicus 0-5 24395567-3 2014 Our experiments led to the identification of sirtuin 1 (SIRT1) as a potential target in T-H. Administration of resveratrol (a naturally occurring polyphenol and activator of SIRT1) after T-H improved left ventricular function and tissue ATP levels. Polyphenols 146-156 sirtuin 1 Rattus norvegicus 45-54 28817690-1 2017 BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Polyphenols 66-76 sirtuin 1 Rattus norvegicus 111-120 28817690-1 2017 BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Polyphenols 66-76 sirtuin 1 Rattus norvegicus 122-127 24631135-0 2014 Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100beta secretion by regulating sirtuin 1 in C6 rat glioma cells. Polyphenols 9-20 sirtuin 1 Rattus norvegicus 113-122 24395567-3 2014 Our experiments led to the identification of sirtuin 1 (SIRT1) as a potential target in T-H. Administration of resveratrol (a naturally occurring polyphenol and activator of SIRT1) after T-H improved left ventricular function and tissue ATP levels. Polyphenols 146-156 sirtuin 1 Rattus norvegicus 56-61 21269399-3 2011 Resveratrol, a plant polyphenol, is reported to activate endothelial NO synthase (eNOS) through activation of sirtuin 1. Polyphenols 21-31 sirtuin 1 Rattus norvegicus 110-119 23461657-0 2013 A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. Polyphenols 10-20 sirtuin 1 Rattus norvegicus 115-120 23461657-1 2013 Polyphenol resveratrol (RSV) has been associated with Silent Information Regulator T1 (SIRT1) and AMP-activated protein kinase (AMPK) metabolic stress sensors and probably responds to the intracellular energy status. Polyphenols 0-10 sirtuin 1 Rattus norvegicus 54-85 23461657-1 2013 Polyphenol resveratrol (RSV) has been associated with Silent Information Regulator T1 (SIRT1) and AMP-activated protein kinase (AMPK) metabolic stress sensors and probably responds to the intracellular energy status. Polyphenols 0-10 sirtuin 1 Rattus norvegicus 87-92 20429690-2 2010 Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetylase activity. Polyphenols 25-35 sirtuin 1 Rattus norvegicus 51-56 20673376-3 2010 The present study was designed to determine whether a polyphenol extract (PPE), from red grapes, modulates liver fatty acid composition and desaturase activity indexes in rats fed a high-fat-high-sucrose (HFHS) diet, and to explore whether sirtuin-1 deacetylase activation was implicated in the effect of the PPE against liver steatosis. Polyphenols 54-64 sirtuin 1 Rattus norvegicus 240-249 19415680-1 2009 Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Polyphenols 15-25 sirtuin 1 Rattus norvegicus 77-81 35337137-0 2022 New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds. Polyphenols 35-46 sirtuin 1 Rattus norvegicus 50-59 18420994-1 2008 OBJECTIVE: Resveratrol (3,5,4"-trihydroxystilbene), a polyphenol found in red wine, is known to activate sirtuin1 (SIRT1), a longevity gene. Polyphenols 54-64 sirtuin 1 Rattus norvegicus 105-113 18420994-1 2008 OBJECTIVE: Resveratrol (3,5,4"-trihydroxystilbene), a polyphenol found in red wine, is known to activate sirtuin1 (SIRT1), a longevity gene. Polyphenols 54-64 sirtuin 1 Rattus norvegicus 115-120 16813520-13 2006 Treatment with the plant polyphenol resveratrol as well as isonicotinamide, both of which activate Sirt1, blocked adipocyte development and increased the expression of osteoblast markers. Polyphenols 25-35 sirtuin 1 Rattus norvegicus 99-104