PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31557846-5 2019 The transported polyphenols were able to prevent IL-8 production and suppress the gene expression of proinflammatory mediators (TNF-alpha, ICAM-1, VCAM-1, and COX-2) in the TNF-alpha or oxidized low-density lipoprotein (ox-LDL) treated EA.hy926 cells. Polyphenols 16-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 159-164 34207896-8 2021 These preliminary findings show that dietary polyphenols modulate inflammatory and apoptotic activities in rabbit ovary, regulating cyclooxygenase-2 and BAX expression, thus suggesting a functional involvement of these dietary compounds in mammalian reproduction. Polyphenols 45-56 prostaglandin-endoperoxide synthase 2 Homo sapiens 132-148 31888113-0 2019 Endoplasmic Reticulum Stress-Induced Resistance to Doxorubicin Is Reversed by Mulberry Leaf Polyphenol Extract in Hepatocellular Carcinoma through Inhibition of COX-2. Polyphenols 92-102 prostaglandin-endoperoxide synthase 2 Homo sapiens 161-166 27750207-1 2016 Free radical scavenging and inhibitory potency against cyclooxygenase-2 (COX-2) by two abundant colon metabolites of polyphenols, i.e., 3-hydroxyphenylacetic acid (3-HPAA) and 4-hydroxyphenylpropionic acid (4-HPPA) were theoretically studied. Polyphenols 117-128 prostaglandin-endoperoxide synthase 2 Homo sapiens 55-71 29532213-4 2018 Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2). Polyphenols 10-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 499-515 29532213-4 2018 Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-alpha) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2). Polyphenols 10-21 prostaglandin-endoperoxide synthase 2 Homo sapiens 517-522 29312947-0 2017 Taheebo Polyphenols Attenuate Free Fatty Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2. Polyphenols 8-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 125-141 29068698-0 2017 The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer. Polyphenols 22-33 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-42 29068698-4 2017 Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid. Polyphenols 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 153-169 29068698-4 2017 Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, and TNF-alpha, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid. Polyphenols 0-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 171-176 29068698-6 2017 This paper reviews the current state of knowledge concerning the potential of various dietary polyphenols to inhibit the effects of COX-2 in colon cancer, by examining the available evidence regarding the efficacy and safety of these compounds obtained from in vitro and animal studies. Polyphenols 94-105 prostaglandin-endoperoxide synthase 2 Homo sapiens 132-137 27750207-1 2016 Free radical scavenging and inhibitory potency against cyclooxygenase-2 (COX-2) by two abundant colon metabolites of polyphenols, i.e., 3-hydroxyphenylacetic acid (3-HPAA) and 4-hydroxyphenylpropionic acid (4-HPPA) were theoretically studied. Polyphenols 117-128 prostaglandin-endoperoxide synthase 2 Homo sapiens 73-78 27750207-0 2016 Free radical scavenging and COX-2 inhibition by simple colon metabolites of polyphenols: A theoretical approach. Polyphenols 76-87 prostaglandin-endoperoxide synthase 2 Homo sapiens 28-33 26043379-7 2015 A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme. Polyphenols 43-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 206-222 26043379-7 2015 A negative correlation existed between the polyphenol concentration of the extracts and pro-inflammatory cytokines: Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), prostaglandin (PGE2), and cyclooxygenase-2 (COX-2) enzyme. Polyphenols 43-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 224-229 15626591-5 2005 This review highlights the importance of C/EBP beta and NF-kappa B in COX-2 transcriptional activation by proinflammatory mediators and as targets of inhibition by endogenous molecules such as melatonin and natural products including salicylate and polyphenols. Polyphenols 249-260 prostaglandin-endoperoxide synthase 2 Homo sapiens 70-75 24836925-0 2014 Wine polyphenols exert antineoplasic effect on androgen resistant PC-3 cell line through the inhibition of the transcriptional activity of COX-2 promoter mediated by NF-kbeta. Polyphenols 5-16 prostaglandin-endoperoxide synthase 2 Homo sapiens 139-144 24836925-3 2014 We intend to clarify whether resveratrol and other polyphenols effectively inhibit COX-2 activity and induce apoptosis in hormone-resistant PC-3 cell line. Polyphenols 51-62 prostaglandin-endoperoxide synthase 2 Homo sapiens 83-88 24836925-16 2014 CONCLUSIONS: Polyphenols inhibit transcriptional activity of COX-2 promoter mediated by NF-kbeta. Polyphenols 13-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 61-66 21598179-0 2011 Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97). Polyphenols 10-20 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 21598179-8 2011 Polyphenol metabolites did not affect cell number but significantly upregulated GSTT2 expression and decreased COX-2. Polyphenols 0-10 prostaglandin-endoperoxide synthase 2 Homo sapiens 111-116 21598179-11 2011 An upregulation of GSTT2 and downregulation of COX-2 could possibly contribute to the chemopreventive potential of polyphenols after degradation in the gut. Polyphenols 115-126 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-52 17825902-0 2007 Grape polyphenols affect mRNA expression of PGHS-2, TIS11b and FOXO3 in endometrium of heifers under ACTH-induced stress. Polyphenols 6-17 prostaglandin-endoperoxide synthase 2 Homo sapiens 44-50 17825902-14 2007 An interesting role of polyphenols in modulating the expression levels of PGHS-2 in endometrial tissue and on the activation of TIS11b and SOD2 through c-AMP-dependent signalling was suggested. Polyphenols 23-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 74-80 16508969-0 2006 Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Polyphenols 10-20 prostaglandin-endoperoxide synthase 2 Homo sapiens 61-77