PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24262216-8	2014	In addition, the links between natural products (e.g. polyphenols) and their associated modules and TFs are helpful to elucidate their polypharmacological effects in terms of activating specific TFs, such as ERs, nuclear factor-like 2 and peroxisome proliferator-activated receptor gamma.	Polyphenols	54-65	peroxisome proliferator activated receptor gamma	Homo sapiens	213-287	
21788573-8	2011	To define the role of PPARgamma in modulating polyphenol effects, small interfering RNA technique and PPARgamma antagonist were used to inhibit transcription factor activity.	Polyphenols	46-56	peroxisome proliferator activated receptor gamma	Homo sapiens	22-31	
21788573-11	2011	It is interesting that PPARgamma inhibition counteracted the polyphenol-induced adiponectin and GLUT4 upregulations, suggesting a direct involvement of PPARgamma in this process.	Polyphenols	61-71	peroxisome proliferator activated receptor gamma	Homo sapiens	23-32	
21788573-11	2011	It is interesting that PPARgamma inhibition counteracted the polyphenol-induced adiponectin and GLUT4 upregulations, suggesting a direct involvement of PPARgamma in this process.	Polyphenols	61-71	peroxisome proliferator activated receptor gamma	Homo sapiens	152-161	
34361774-2	2021	The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-kappaB and PPAR-gamma receptor.	Polyphenols	9-19	peroxisome proliferator activated receptor gamma	Homo sapiens	294-304	
33293765-0	2020	Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-gamma and SOCS1 induction.	Polyphenols	7-17	peroxisome proliferator activated receptor gamma	Homo sapiens	113-123	
27845788-8	2016	The PPARgamma protein, ABCA1 protein and CYP7A1 protein were up-regulated in L-02 cells treated with the three tested polyphenols.	Polyphenols	118-129	peroxisome proliferator activated receptor gamma	Homo sapiens	4-13	
26604687-0	2015	In silico approach for the discovery of new PPARgamma modulators among plant-derived polyphenols.	Polyphenols	85-96	peroxisome proliferator activated receptor gamma	Homo sapiens	44-53	
26604687-4	2015	Based on recent evidence obtained with plant-derived polyphenols, the present in silico study aimed at finding new selective human PPARgamma (hPPARgamma) modulators that are able to improve glucose homeostasis with reduced side effects compared with TZDs.	Polyphenols	53-64	peroxisome proliferator activated receptor gamma	Homo sapiens	131-140	
26604687-4	2015	Based on recent evidence obtained with plant-derived polyphenols, the present in silico study aimed at finding new selective human PPARgamma (hPPARgamma) modulators that are able to improve glucose homeostasis with reduced side effects compared with TZDs.	Polyphenols	53-64	peroxisome proliferator activated receptor gamma	Homo sapiens	142-152	
23990052-0	2013	Epigallocatechin-3-O-gallate, a green tea polyphenol, induces expression of pim-1 kinase via PPARgamma in human vascular endothelial cells.	Polyphenols	42-52	peroxisome proliferator activated receptor gamma	Homo sapiens	93-102	
35441186-4	2022	Our results showed that the existence of the galloyl moiety in the structure of polyphenols was necessary for their inhibition of adipogenic differentiation, which could help to delay cells from entering the G2/M phase as well as to hinder the MCE process in the early stage of differentiation and the downstream PPARgamma and C/EBPalpha related MAPK signaling pathway, probably via binding to IR and disturbing the alpha-helix in its conformation.	Polyphenols	80-91	peroxisome proliferator activated receptor gamma	Homo sapiens	313-322	
30832407-4	2019	All polyphenols, except cyanidin, inhibited the effects on FAS and PPARgamma and further increased CPT1A1 expression, suggesting a shift toward increased beta-oxidation.	Polyphenols	4-15	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76