PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28533128-5 2017 B[a]P increased expression of genes related to oxidative stress and inflammation (Nrf2, UCP2, and TNF-alpha) after 24 h. Polyphenols strongly inhibited the increase in TNF-alpha and also several polyphenols inhibited the increase in UCP2. Polyphenols 121-132 nuclear factor, erythroid derived 2, like 2 Mus musculus 82-86 28386616-2 2017 Hydroxytyrosol (HT), a polyphenol with cytoprotective effects present in extra virgin olive oil, improves the cellular antioxidant capacity for activation of transcription factor Nrf2. Polyphenols 23-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 179-183 33803136-7 2021 Interestingly, representative PPEP polyphenols mediated the induction of Nrf2 target genes cell-autonomously in adipocytes, suggesting that this induction may be related to the specific polyphenol content of PPEP. Polyphenols 35-46 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 26811344-0 2016 Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice. Polyphenols 43-54 nuclear factor, erythroid derived 2, like 2 Mus musculus 110-114 27550943-0 2016 A Novel Polyphenol Conjugate Sensitizes Cisplatin-Resistant Head and Neck Cancer Cells to Cisplatin via Nrf2 Inhibition. Polyphenols 8-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 104-108 27417135-8 2016 These findings suggested that polyphenol Nrf2 modulators, especially combined with drugs activating AMP-activated protein kinase, including hypoglycemic drugs, are worthy of further investigation to combat diabetic complications. Polyphenols 30-40 nuclear factor, erythroid derived 2, like 2 Mus musculus 41-45 27166148-2 2016 Our recent studies with immortalized murine microglial cells (BV-2) demonstrated effects of botanical polyphenols to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) and enhance Nrf2-mediated antioxidant responses (Sun et al., 2015). Polyphenols 102-113 nuclear factor, erythroid derived 2, like 2 Mus musculus 188-192 33803136-7 2021 Interestingly, representative PPEP polyphenols mediated the induction of Nrf2 target genes cell-autonomously in adipocytes, suggesting that this induction may be related to the specific polyphenol content of PPEP. Polyphenols 35-45 nuclear factor, erythroid derived 2, like 2 Mus musculus 73-77 34146850-2 2021 This study investigated the effects of polyphenols from Pterocarpus santalinus hydroalcoholic extract (PSHE) against gamma radiation-induced derangements via the upregulation of Nrf2. Polyphenols 39-50 nuclear factor, erythroid derived 2, like 2 Mus musculus 178-182 34737813-0 2021 Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells. Polyphenols 4-15 nuclear factor, erythroid derived 2, like 2 Mus musculus 92-96 34737813-0 2021 Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells. Polyphenols 4-15 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 34829046-0 2021 Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation. Polyphenols 34-44 nuclear factor, erythroid derived 2, like 2 Mus musculus 99-103 31410984-1 2019 SCOPE: Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2-related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown. Polyphenols 7-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-130 34129203-2 2021 Mangiferin (MA), a polyphenol compound, has been reported to activate Nrf2/antioxidant-responsive element (ARE) signaling pathway. Polyphenols 19-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 70-74 35326124-0 2022 Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway. Polyphenols 0-10 nuclear factor, erythroid derived 2, like 2 Mus musculus 105-109 35284456-0 2022 Green Tea Polyphenols Upregulate the Nrf2 Signaling Pathway and Suppress Oxidative Stress and Inflammation Markers in D-Galactose-Induced Liver Aging in Mice. Polyphenols 10-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 37-41 32871358-0 2021 Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-kappaB and Nrf2 pathways. Polyphenols 28-39 nuclear factor, erythroid derived 2, like 2 Mus musculus 139-143 32871358-2 2021 In this study, we evaluated the underlying immunomodulatory activity of polyphenol extracts of thinned peach (PETP) via the NF-kappaB and Nrf2 signaling pathways in RAW264.7 macrophages. Polyphenols 72-82 nuclear factor, erythroid derived 2, like 2 Mus musculus 138-142 32750449-0 2020 Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways. Polyphenols 10-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 133-137 34097996-0 2021 Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata sensitizes prostate cancer cells in vitro and in vivo. Polyphenols 114-124 nuclear factor, erythroid derived 2, like 2 Mus musculus 77-81 35460827-2 2022 To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways. Polyphenols 56-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 208-244 35460827-2 2022 To study the anti-inflammatory influence of jujube peel polyphenols in lipopolysaccharide (LPS) induced RAW 264.7 cells through mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and nuclear erythroid 2-related factor 2 (Nrf2) signaling pathways. Polyphenols 56-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 246-250 35460827-5 2022 Additionally, jujube peel polyphenol activate Nrf2 from the cytoplasm to the nucleus, regulate antioxidant enzymes and pro-inflammatory cytokines, and reduce oxidative stress and inflammatory responses. Polyphenols 26-36 nuclear factor, erythroid derived 2, like 2 Mus musculus 46-50 35460827-6 2022 Results obtained from this study suggest that jujube peel polyphenols may alleviate oxidative stress and inflammation by inhibiting MAPK and NF-kappaB and activating Nrf2 signaling pathways. Polyphenols 58-69 nuclear factor, erythroid derived 2, like 2 Mus musculus 166-170 32447828-6 2020 In vitro, polyphenols improved ROS levels, Cu/ZnSOD activity and both Nox4 and Nrf2 gene expression deregulated by high glucose. Polyphenols 10-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 79-83 32447828-7 2020 Polyphenols reduced Nrf2 nuclear translocation, and counteracted NFkB pathway activation, IL-6 secretion and the altered production of vasoactive markers mediated by high glucose. Polyphenols 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 20-24 32172946-0 2020 Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway. Polyphenols 10-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 105-110 31410984-1 2019 SCOPE: Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2-related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown. Polyphenols 7-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 140-144 29063666-3 2018 Previously, we demonstrated that induction of antioxidant enzymes by Nrf2 activation using Nrf2-gene transfer, an ETGE-peptide or polyphenols, successfully ameliorated RANKL-dependent osteoclastogenesis. Polyphenols 130-141 nuclear factor, erythroid derived 2, like 2 Mus musculus 69-73 29864924-0 2018 Antioxidant mechanism of polyphenol-rich Nymphaea nouchali leaf extract protecting DNA damage and attenuating oxidative stress-induced cell death via Nrf2-mediated heme-oxygenase-1 induction coupled with ERK/p38 signaling pathway. Polyphenols 25-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 150-154