PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12840208-11	2003	Several polyphenols suppressed phosphorylation of AKT and ERK1/2, and more potently inhibited IRS-1 tyrosyl phosphorylation after IGF-I exposure.	Polyphenols	8-19	AKT serine/threonine kinase 1	Rattus norvegicus	50-53	
22381400-3	2012	We further studied the involvement of neuroprotective pathway protein AKT in green tea polyphenols protection against iAbeta-induced cytotoxicity on cultured rat primary prefrontal cortical neurons.	Polyphenols	87-98	AKT serine/threonine kinase 1	Rattus norvegicus	70-73	
22381400-4	2012	The results demonstrated that the content of p-AKT decreased significantly after iAbeta treatment, while administration of green tea polyphenols significantly inhibited the iAbeta-induced decrease in the content of p-AKT.	Polyphenols	133-144	AKT serine/threonine kinase 1	Rattus norvegicus	217-220	
22381400-5	2012	Moreover, blockade of AKT signalling inhibited the protective effects of green tea polyphenols against iAbeta-induced neurotoxicity.	Polyphenols	83-94	AKT serine/threonine kinase 1	Rattus norvegicus	22-25	
22381400-6	2012	The results suggest that green tea polyphenols may play a protective effect on cultured rat primary prefrontal cortical neurons against iAbeta-induced cytotoxicity and AKT is involved in the green tea polyphenols-induced protective effects.	Polyphenols	201-212	AKT serine/threonine kinase 1	Rattus norvegicus	168-171	
19936622-0	2011	Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	26-37	AKT serine/threonine kinase 1	Rattus norvegicus	114-117	
19496785-5	2009	Western blot analyses showed that resveratrol (10 microM) and quercetin (25 microM) caused a reduction in phosphorylation of Akt, but this reduction was not sufficient by itself to mediate the effects of these polyphenols.	Polyphenols	210-221	AKT serine/threonine kinase 1	Rattus norvegicus	125-128	
34673854-0	2021	Protective action of pomegranate peel polyphenols in type 2 diabetic rats via the translocation of Nrf2 and FoxO1 regulated by the PI3K/Akt pathway.	Polyphenols	38-49	AKT serine/threonine kinase 1	Rattus norvegicus	136-139	
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Polyphenols	4-15	AKT serine/threonine kinase 1	Rattus norvegicus	99-102	
32204114-0	2020	Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway.	Polyphenols	27-37	AKT serine/threonine kinase 1	Rattus norvegicus	139-142	
29248832-0	2018	Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation.	Polyphenols	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	143-146	
30374328-0	2018	Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3beta and Inhibition of IRE1alpha-XBP1 Pathways.	Polyphenols	47-58	AKT serine/threonine kinase 1	Rattus norvegicus	106-109	
31392548-0	2019	Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.	Polyphenols	41-52	AKT serine/threonine kinase 1	Rattus norvegicus	129-132	
30320189-4	2018	Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR.	Polyphenols	25-35	AKT serine/threonine kinase 1	Rattus norvegicus	123-126