PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32645737-0 2020 Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice. Polyphenols 11-22 brain expressed, associated with Nedd4, 1 Mus musculus 6-10 32645737-2 2020 Cacao bean polyphenols have recently gained considerable attention for their beneficial effects on cardiovascular diseases. Polyphenols 11-22 brain expressed, associated with Nedd4, 1 Mus musculus 6-10 32645737-7 2020 In cardiomyocytes, cacao bean polyphenols significantly suppressed phenylephrine-induced cardiomyocyte hypertrophy and hypertrophic gene transcription. Polyphenols 30-41 brain expressed, associated with Nedd4, 1 Mus musculus 25-29 32645737-8 2020 Extracellular signal-regulated kinase 1/2 and GATA binding protein 4 phosphorylation induced by phenylephrine was inhibited by cacao bean polyphenols treatment in the cardiomyocytes. Polyphenols 138-149 brain expressed, associated with Nedd4, 1 Mus musculus 133-137 32645737-9 2020 Cacao bean polyphenols treatment at 1200 mg/kg significantly ameliorated left ventricular posterior wall thickness, fractional shortening, hypertrophic gene transcription, cardiac hypertrophy, cardiac fibrosis, and extracellular signal-regulated kinase 1/2 phosphorylation induced by pressure overload. Polyphenols 11-22 brain expressed, associated with Nedd4, 1 Mus musculus 6-10 32645737-10 2020 In conclusion, these findings suggest that cacao bean polyphenols prevent pressure overload-induced cardiac hypertrophy and systolic dysfunction by inhibiting the extracellular signal-regulated kinase 1/2-GATA binding protein 4 pathway in cardiomyocytes. Polyphenols 54-65 brain expressed, associated with Nedd4, 1 Mus musculus 49-53