PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25139172-4	2015	In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes.	Polyphenols	32-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129	
26440517-0	2015	Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity.	Polyphenols	5-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73	
26440517-4	2015	This study characterized effects of a subset of polyphenols on COX-2 expression and activity in vitro and compared the potency with known drugs.	Polyphenols	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68	
26440517-6	2015	Enzyme assays and incubations of polyphenols with the cancer cell line HCA-7 and lipopolysaccharide (LPS) stimulated primary monocytes support the hypothesis that polyphenols can effect COX-2 expression and activity in vitro.	Polyphenols	163-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191	
25710724-0	2015	Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf.	Polyphenols	18-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77	
11103814-8	2000	Among the tea polyphenols tested, TF-2 and, to a lesser degree, (-)-epigallocatechin gallate inhibited cyclooxygenase (Cox)-2 gene expression.	Polyphenols	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-125	
22595400-0	2012	Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer.	Polyphenols	19-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87	
22595400-8	2012	Our findings reveal that olive oil and red wine polyphenols reduce inflammatory angiogenesis in cultured endothelial cells, through MMP-9 and COX-2 inhibition, supporting a potential protective role for dietary polyphenols in atherosclerotic vascular disease and cancer.	Polyphenols	48-59	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	142-147	
15662752-18	2004	Several nutritional polyphenols (the secondary metabolites of plants) are COX2 and/or LOX inhibitors and iNOS activators.	Polyphenols	20-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-78	
30802511-10	2019	Based on the shift in the omega-6/omega-3 balance towards omega-6, as well as the increase in COX-2 and TNFalpha protein expressions, we may postulate a pro-inflammatory nature of the examined polyphenol.	Polyphenols	193-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99	
27974694-0	2017	Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells.	Polyphenols	21-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-70