PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33232763-0 2021 Tea polyphenols inhibit the growth and virulence of ETEC K88. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 33232763-4 2021 Tea polyphenols have numerous important biological functions, including antibacterial, antiviral, antioxidative, anti-inflammatory, and antihypertensive effects. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 33232763-6 2021 Pretreating with tea polyphenols attenuated the symptoms induced by ETEC K88. Polyphenols 21-32 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 17-20 33232763-7 2021 Furthermore, in a cell adherence assay, tea polyphenols inhibited ETEC K88 adherence to IPEC-J2 cells. Polyphenols 44-55 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 40-43 33232763-9 2021 However, when cells were pretreated with tea polyphenols, claudin-1 mRNA and protein levels were higher than those in cells without pretreatment upon cell infection with ETEC K88. Polyphenols 45-56 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 41-44 33232763-10 2021 TLR2 mRNA levels were also higher following cell infection with ETEC K88 when cells were pretreated with tea polyphenols. Polyphenols 109-120 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 105-108 33232763-11 2021 These data revealed that tea polyphenols could increase the barrier integrity of IPEC-J2 cells by upregulating expression of claudin-1 through activation of TLR2. Polyphenols 29-40 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 25-28 33232763-12 2021 Tea polyphenols had beneficial effects on epithelial barrier function. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 33232763-13 2021 Therefore, tea polyphenols could be used as a novel strategy to control and treat pig infections caused by ETEC K88. Polyphenols 15-26 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 11-14 35133795-0 2022 Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Block Pyroptosis in Endotoxin-Induced Sepsis. Polyphenols 55-66 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 51-54 35471225-0 2022 Tea polyphenols alleviate the adverse effects of diabetes on oocyte quality. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 35471225-3 2022 Polyphenols are the most abundant bioactive components of green tea. Polyphenols 0-11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 64-67 35471225-4 2022 It is reported that tea polyphenols have many health functions, for instance anti-oxidation, anti-inflammation, anti-obesity, and anti-diabetes. Polyphenols 24-35 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 20-23 35471225-5 2022 Thus, we hypothesize that tea polyphenols may play a crucial role in alleviating adverse effects of diabetes on oocyte quality. Polyphenols 30-41 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 26-29 35471225-6 2022 In the present study, we researched the effects of tea polyphenols on diabetic oocyte maturation in vitro. Polyphenols 55-66 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 51-54 35471225-8 2022 However, tea polyphenols significantly increased the oocyte maturation rate, and reduced the incidence of abnormal spindle assembly and chromosome segregation. Polyphenols 13-24 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 9-12 35471225-9 2022 Tea polyphenols also obviously decreased the reactive oxygen species (ROS) levels in diabetic oocytes, and increased the expression of antioxidant genes (Sod1 and Sod2). Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 35471225-10 2022 Abnormal mitochondrial membrane potential was also alleviated in diabetic oocytes, and the expression of genes regulating mitochondrial fusion (Opa1, Mfn1 and Mfn2) and fission (Drp1) was significantly increased while tea polyphenols were added. Polyphenols 222-233 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 218-221 35471225-11 2022 Meanwhile, tea polyphenols reduced DNA damage in diabetic oocytes which may be mediated by the increased expression of Rad51, related to DNA damage repair. Polyphenols 15-26 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 11-14 35471225-12 2022 Our results suggest that tea polyphenols would, at least partially, restore the adverse effects of diabetes mellitus on oocyte quality. Polyphenols 29-40 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 25-28 35275634-3 2022 In this study, transmission electron microscopy results demonstrate the existence of CDs in herbal tea, while Fourier transform infrared and X-ray photoelectron spectroscopy results suggest the participation of polyphenol in herbal tea CD (H-CD) formation. Polyphenols 211-221 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 232-235 35133795-3 2022 Here we reported drug-free tea polyphenols nanoparticles (TPNs) with intrinsic broad-spectrum RONS scavenging and pyroptosis-blocking activities to treat endotoxin (LPS)-induced sepsis in mice. Polyphenols 31-42 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 27-30 31793191-0 2020 Tea polyphenols alleviate tri-ortho-cresyl phosphate-induced autophagy of mouse ovarian granulosa cells. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 35112849-0 2022 Omics Analyses of Intestinal Microbiota and Hypothalamus Clock Genes in Circadian Disturbance Model Mice Fed with Green Tea Polyphenols. Polyphenols 124-135 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 120-123 35112849-1 2022 Green tea polyphenols (GTP) have similar activities as prebiotics, which effectively regulate the structure of intestinal flora and affect their metabolic pathways. Polyphenols 10-21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 33273950-0 2020 Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters. Polyphenols 10-21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 33273950-1 2020 Green tea polyphenols (GTPs) have been shown to exhibit diverse beneficial effects against a variety of diseases. Polyphenols 10-21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 32453025-0 2020 Tea polyphenols protect learning and memory in sleep-deprived mice by promoting AMPA receptor internalization. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 32453025-6 2020 Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 32453025-6 2020 Tea polyphenols, major active compounds in green tea, suppressed TNFalpha production through downregulating TNFalpha converting enzyme (TACE) level. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 49-52 32453025-7 2020 Meanwhile, tea polyphenols treatment could ameliorate recognition impairment and anxiety-like behaviors in S-DEP mice. Polyphenols 15-26 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 11-14 32453025-8 2020 The aforementioned results demonstrate cognition protective effects of tea polyphenols in S-DEP mice model, which provide a theoretical basis for the treatments of S-DEP-induced cognition impairment by targeting the TACE/TNFalpha/AMPA pathway. Polyphenols 75-86 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 71-74 31793191-2 2020 Tea polyphenols (TPs) have multiple health effects via inhibiting oxidative stress. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 31212946-11 2019 Taken together, our findings show that constituents found in all major tea types, predominantly L-theanine, polyphenols and polyphenol metabolites, are capable of functioning through multiple pathways simultaneously to collectively reduce the risk of depression. Polyphenols 108-118 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 71-74 31665823-0 2020 Translating In Vitro Acrolein-Trapping Capacities of Tea Polyphenol and Soy Genistein to In Vivo Situation is Mediated by the Bioavailability and Biotransformation of Individual Polyphenols. Polyphenols 57-67 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 53-56 31665823-0 2020 Translating In Vitro Acrolein-Trapping Capacities of Tea Polyphenol and Soy Genistein to In Vivo Situation is Mediated by the Bioavailability and Biotransformation of Individual Polyphenols. Polyphenols 178-189 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 53-56 31480575-0 2019 Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice. Polyphenols 22-32 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 9-12 31212946-11 2019 Taken together, our findings show that constituents found in all major tea types, predominantly L-theanine, polyphenols and polyphenol metabolites, are capable of functioning through multiple pathways simultaneously to collectively reduce the risk of depression. Polyphenols 108-119 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 71-74 31773068-7 2019 Methods: A course of antibiotics (clindamycin, piperacillin/tazobactam, or aztreonam) was administered SC daily (days 1 and 2) to mice receiving polyphenol-rich green tea in drinking water. Polyphenols 145-155 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 167-170 31184120-0 2019 Correlation Analysis of Intestinal Redox State with the Gut Microbiota Reveals the Positive Intervention of Tea Polyphenols on Hyperlipidemia in High Fat Diet Fed Mice. Polyphenols 112-123 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 108-111 31184120-1 2019 Tea polyphenols (TP) possess the ability to regulate dyslipidemia and gut microbiota dysbiosis. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 31312655-0 2019 Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. Polyphenols 62-73 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 58-61 31312655-2 2019 Tea polyphenols exert multiple beneficial effects on human health and may play a positive regulatory role in fat assumption. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 31312655-4 2019 Small RNA expression profile can be regulated by tea polyphenols in adipocytes. Polyphenols 53-64 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 49-52 31312655-5 2019 Therefore, tea polyphenols may regulate fat metabolism by controlling small RNA-associated biological processes. Polyphenols 15-26 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 11-14 31312655-6 2019 In this study, we developed a systematic research platform based on mouse models and performed small RNA sequencing to identify the specific role of small RNAs in the regulatory effect of tea polyphenols on fat metabolism. Polyphenols 192-203 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 188-191 31312655-8 2019 Most of these small RNAs participate in lipid metabolism, suggesting that small RNAs play a significant role in tea polyphenol-associated obesity and related pathogenesis. Polyphenols 116-126 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 112-115 31312655-9 2019 Furthermore, gene ontology and KEGG pathway enrichment indicated that small RNAs influence the regulatory effects of tea polyphenols on obesity, revealing the potential pathogenic mechanisms for such nutritional disease. Polyphenols 121-132 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 117-120 30875793-0 2019 Liver Injury Induced by Carbon Tetrachloride in Mice Is Prevented by the Antioxidant Capacity of Anji White Tea Polyphenols. Polyphenols 112-123 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 108-111 30871261-0 2019 Protective Effects of Kuding Tea (Ilex kudingcha C. J. Tseng) Polyphenols on UVB-Induced Skin Aging in SKH1 Hairless Mice. Polyphenols 62-73 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 29-32 30871261-2 2019 The ion precipitation method was used for extraction of polyphenols from Kuding tea. Polyphenols 56-67 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 80-83 30875793-1 2019 Anji white tea is a unique variety of green tea that is rich in polyphenols. Polyphenols 64-75 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 11-14 30875793-1 2019 Anji white tea is a unique variety of green tea that is rich in polyphenols. Polyphenols 64-75 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 44-47 30875793-2 2019 In this study, the effect of Anji white tea polyphenols (AJWTP) on the prevention of carbon tetrachloride (CCl4)-induced liver injury through its antioxidant properties was studied. Polyphenols 44-55 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 40-43 29351230-0 2018 Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice. Polyphenols 79-90 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 62-65 30606217-0 2019 Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model. Polyphenols 25-35 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 21-24 30388863-0 2018 Preventive Effect of Raw Liubao Tea Polyphenols on Mouse Gastric Injuries Induced by HCl/Ethanol via Anti-Oxidative Stress. Polyphenols 36-47 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 32-35 30388863-2 2018 This study is a basic research of the contained polyphenols (active substances) and detected preventive effects of polyphenols of raw Liubao tea (PRLT) on mouse gastric injuries induced by HCl/ethanol. Polyphenols 115-126 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 141-144 30510092-0 2018 Editor"s Note: Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems. Polyphenols 72-83 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 68-71 29278293-0 2018 Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice. Polyphenols 10-20 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 29351230-0 2018 Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice. Polyphenols 79-90 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 62-65 29351230-2 2018 Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. Polyphenols 11-22 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 7-10 29351230-2 2018 Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. Polyphenols 58-69 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 41-44 29351230-2 2018 Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. Polyphenols 58-69 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 41-44 29351230-2 2018 Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. Polyphenols 58-69 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 41-44 29351230-2 2018 Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. Polyphenols 58-69 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 41-44 29351230-3 2018 The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice. Polyphenols 82-93 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 78-81 29351230-3 2018 The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice. Polyphenols 129-140 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 112-115 29351230-3 2018 The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice. Polyphenols 129-140 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 112-115 29061705-0 2018 Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice. Polyphenols 0-10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 51-54 29359608-0 2018 Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the down-regulation of TLR4. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 29359608-2 2018 Toll-like receptor 4 (TLR4) had been reported to play an important role in melanoma, and tea polyphenol (TP) is regarded as an anticancer substance. Polyphenols 93-103 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 89-92 29163391-5 2017 After cultivation of 48 h, tea polyphenols, caffeine, and L-theanine decreased by 31.0, 26.2, and 8.3%, respectively. Polyphenols 31-42 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 27-30 27882175-0 2016 Tea polyphenols protect against ischemia/reperfusion-induced liver injury in mice through anti-oxidative and anti-apoptotic properties. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 28777810-0 2017 Green tea polyphenol treatment attenuates atherosclerosis in high-fat diet-fed apolipoprotein E-knockout mice via alleviating dyslipidemia and up-regulating autophagy. Polyphenols 10-20 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 28777810-1 2017 BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood. Polyphenols 22-32 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 18-21 28777810-1 2017 BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood. Polyphenols 22-32 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 73-76 28777810-1 2017 BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood. Polyphenols 44-54 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 18-21 28777810-1 2017 BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood. Polyphenols 44-54 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 73-76 27206430-0 2017 Delayed Treatment with Green Tea Polyphenol EGCG Promotes Neurogenesis After Ischemic Stroke in Adult Mice. Polyphenols 33-43 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 29-32 28539729-0 2017 Anti-Fatigue Effect of Green Tea Polyphenols (-)-Epigallocatechin-3-Gallate (EGCG). Polyphenols 33-44 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 29-32 28539729-1 2017 BACKGROUND: (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant of the green tea polyphenols that exhibit a variety of bioactivities. Polyphenols 88-99 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 84-87 28066771-3 2016 This study was designed to evaluate the modulation of dietary tea polyphenols (TPs) on intestinal Bifidobacteria (IB) and its correlation with AS development in apolipoprotein E-deficient (ApoE-/-) mice. Polyphenols 66-77 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 62-65 27882175-1 2016 Tea polyphenols (TPs), which are derived from tea extracts, are a class of chemicals containing polyphenol hydroxyls that have been observed to have strong anti-oxidative properties. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 27882175-1 2016 Tea polyphenols (TPs), which are derived from tea extracts, are a class of chemicals containing polyphenol hydroxyls that have been observed to have strong anti-oxidative properties. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 46-49 27058323-0 2016 Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 27389300-0 2016 Fabrication of BSA-Green Tea Polyphenols-Chitosan Nanoparticles and Their Role in Radioprotection: A Molecular and Biochemical Approach. Polyphenols 29-40 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 25-28 27389300-2 2016 Tea polyphenols (TPs) have been shown to reduce radiation-induced damage in multiple studies, but their pharmacological application is still limited due to poor bioavailability. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 26582073-0 2016 Stachyose increases absorption and hepatoprotective effect of tea polyphenols in high fructose-fed mice. Polyphenols 66-77 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 62-65 26582073-1 2016 SCOPE: The consumption of tea polyphenols (TP) and stachyose contributes to preventive effects on hepatic injury. Polyphenols 30-41 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 26-29 25516005-0 2014 Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Polyphenols 10-20 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 26586942-0 2015 PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma. Polyphenols 22-33 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 18-21 26586942-1 2015 The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability. Polyphenols 49-60 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 45-48 26586942-2 2015 Herein, following the concept of nanochemoprevention, which uses nanotechnology for enhancing the efficacy of chemotherapeutic drugs, we employed tea polyphenols, namely theaflavin (TF) and epigallocatechin-3-gallate (EGCG) encapsulated in a biodegradable nanoparticulate formulation based on poly(lactide-co-glycolide) (PLGA) with approximately 26% and 18% encapsulation efficiency, respectively. Polyphenols 150-161 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 146-149 25498223-0 2015 Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral alpha-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 25498223-1 2015 Tea polyphenols (TPs) are bioactive flavanol-related catechins that have been shown to protect dopaminergic (DAergic) neurons against neurotoxin-induced injury in mouse Parkinson"s disease (PD) models. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 25516005-1 2014 INTRODUCTION: Epigallocatechin 3-gallate (EGCG), a polyphenol present in green tea, was shown to exert chondroprotective effects in vitro. Polyphenols 51-61 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 79-82 24343902-3 2014 In the present study, to examine the involvement of AP-1 in green tea polyphenols induced tumor inhibition, human NSCLC cell line H1299 and mouse SPON 10 cells were identified as AP-1 dependent, as these two lines exhibit high constitutive AP-1 activity, and when TAM67 expression was induced with doxycycline, cell growth was inhibited and correlated with suppressed AP-1 activity. Polyphenols 70-81 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 66-69 24343902-4 2014 RNA-seq was used to determine the global transcriptional effects of AP-1 inhibition and also uncover the possible involvement of AP-1 in tea polyphenols induced chemoprevention. Polyphenols 141-152 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 137-140 22613332-2 2012 The anti-angiogenic effect of tea polyphenols (TPs) on lung carcinoma was confirmed in our previous study. Polyphenols 34-45 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 30-33 23840920-1 2013 Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 23840920-2 2013 In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and cytochrome c (cyt c) in cerebral cortex were detected. Polyphenols 55-66 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 51-54 23840920-7 2013 After pretreatment with tea polyphenols, the neurological outcome was also improved. Polyphenols 28-39 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 24-27 23840920-8 2013 The results provide strong evidence that tea polyphenols enhance neuroprotective effects by inhibiting polarization of mitochondrial membrane potential, increasing ATP content, and blocking cyt c release. Polyphenols 45-56 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 41-44 21789892-0 2011 Tea polyphenol-induced neuron-like differentiation of mouse mesenchymal stem cells. Polyphenols 4-14 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 22754316-1 2012 The purpose of this study was to evaluate the antioxidant nature of tea polyphenol on S180 cells induced liver cancer in mice. Polyphenols 72-82 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 68-71 22754316-3 2012 The antitumor activity of tea polyphenol has been determined in vivo in hepatocellular carcinoma mice after treatment of drug (50, 100, 150 mg/kg body weight) by gavage for 20 days. Polyphenols 30-40 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 26-29 22754316-6 2012 These altered enzyme levels were ameliorated significantly by administration of tea polyphenol at the concentration of 50, 100, 150 mg/kg body weight in drug-treated animals. Polyphenols 84-94 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 80-83 22754316-7 2012 These results indicate that the protective effect of tea polyphenol was associated with inhibition of MDA induced by S180 cells and to maintain the antioxidant enzyme levels. Polyphenols 57-67 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 53-56 21452375-6 2011 Tea polyphenols also significantly decreased radiation-induced lipid peroxidation (malondialdehyde levels), elevated endogenous antioxidant enzymes (superoxide dismutase) and reduced the serum cytokines which were elevated in radiation-induced toxicity. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 22181980-5 2011 Tea polyphenols are reported to have excellent chemopreventive properties against cancer. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 22181980-9 2011 Thus, tea polyphenols may prove effective in treating arsenic-induced carcinogenesis. Polyphenols 10-21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 19517063-0 2010 Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 19517063-3 2010 Tea (Camellia sinensis) and its bioactive polyphenols have been associated with prevention of human cancer for several organs. Polyphenols 42-53 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 19517063-4 2010 Thus, intake of tea polyphenols seems to be a viable mean to control lung cancer burden. Polyphenols 20-31 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 16-19 19517063-6 2010 RESULTS: Chemopreventive potential of tea polyphenols, was recorded as evident by, low incidence of alveologenic tumors in lungs of animals at tested doses (0.1% and 0.2% of both GTP and BTP) when compared with DEN (20 mg/kg b wt) treated animals. Polyphenols 42-53 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 38-41 20707208-0 2010 [Protective activity of different concentration of tea polyphenols and its major compound EGCG against whole body irradiation-induced injury in mice]. Polyphenols 55-66 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 51-54 20707208-1 2010 OBJECTIVE: To evaluate the different concentrate of tea polyphenols (TP) and its compound for irradiation-protection and investigate its mechanism. Polyphenols 56-67 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 52-55 16772446-0 2006 Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 19063841-1 2008 OBJECTIVE: To study the anticancer effects of tea polyphenols on colorectal cancer with microsatellite instability (MSI) in nude mice and to explore its mechanism. Polyphenols 50-61 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 46-49 19063841-4 2008 Then, the nude mice were divided into untreated group and 50, 75 and 100 mg/kg tea polyphenols groups. Polyphenols 83-94 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 79-82 19063841-5 2008 The mice in tea polyphenols-treated groups were given intra-abdominal injection of 50, 75 and 100 mg/kg tea polyphenols respectively. Polyphenols 16-27 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 12-15 19063841-5 2008 The mice in tea polyphenols-treated groups were given intra-abdominal injection of 50, 75 and 100 mg/kg tea polyphenols respectively. Polyphenols 16-27 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 104-107 19063841-5 2008 The mice in tea polyphenols-treated groups were given intra-abdominal injection of 50, 75 and 100 mg/kg tea polyphenols respectively. Polyphenols 108-119 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 12-15 19063841-8 2008 The study found that tea polyphenols could inhibit the tumor growth. Polyphenols 25-36 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 21-24 19063841-11 2008 After using the tea polyphenols, the microsatellite tended to become stable. Polyphenols 20-31 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 16-19 19063841-12 2008 CONCLUSION: Tea polyphenols can inhibit the mismatch-repair-gene deficient colorectal cancer in nude mice by down-regulating the microsatellite instability. Polyphenols 16-27 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 12-15 17317271-0 2007 Glucuronide transport across the endoplasmic reticulum membrane is inhibited by epigallocatechin gallate and other green tea polyphenols. Polyphenols 125-136 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 121-124 18656336-0 2009 Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 18656336-2 2009 Progression of lung lesions was restricted at the hyperplastic stage by tea polyphenols. Polyphenols 76-87 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 72-75 18656336-6 2009 The tea polyphenols inhibited inflammatory response in the lung lesions on the 9th week, when decreased expression of H-ras and c-myc and increased expression of bax were noted. Polyphenols 8-19 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 4-7 18656336-7 2009 Prolonged treatment (>9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week). Polyphenols 44-55 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 40-43 18656336-8 2009 These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points. Polyphenols 41-52 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 37-40 19370779-0 2009 Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. Polyphenols 25-36 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 21-24 19370779-1 2009 AIM: To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with cytochrome P450 (CYP450) expression in mice. Polyphenols 57-68 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 53-56 16772446-2 2006 The objective of this study was to determine the bioavailability and bioactivity of tea polyphenols (PP) and theaflavins in human serum and human and mouse tissues. Polyphenols 88-99 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 84-87 21544351-7 1996 Evidence has also accumulated showing that tea polyphenols prevent tumor promoter- and ultraviolet B-induced inflammatory responses in murine skin. Polyphenols 47-58 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 43-46 11807963-1 2002 Tea pigments are oxidized products of polyphenols derived from tea leaves (Camellia sinensis). Polyphenols 38-49 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 11807963-1 2002 Tea pigments are oxidized products of polyphenols derived from tea leaves (Camellia sinensis). Polyphenols 38-49 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 63-66 10837321-0 2000 Tea polyphenols: prevention of cancer and optimizing health. Polyphenols 4-15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 10837321-6 2000 Because the epidemiologic studies and research findings in laboratory animals have shown the chemopreventive potential of tea polyphenols in cancer, the usefulness of tea polyphenols for humans should be evaluated in clinical trials. Polyphenols 126-137 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 122-125 10837321-9 2000 The usefulness of tea polyphenols may be extended by combining them with other consumer products such as food items and vitamin supplements. Polyphenols 22-33 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 18-21 9659588-0 1998 Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. Polyphenols 12-23 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 8-11 9659588-8 1998 Growth inhibition by various tea polyphenols has been demonstrated in human lung H661 and H1299 cells. Polyphenols 33-44 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 29-32 10682639-0 1998 [The antioxidative mechanisms of tea polyphenols in inhibiting tumor promotion by TPA]. Polyphenols 37-48 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 33-36 10682639-1 1998 In the mouse study, topical application of green tea polyphenols (GTP) significantly inhibited TPA-induced increasing of epidermal ornithine decarboxylase (ODC) and increased the activities of several antioxidant enzymes (CAT, GR and GST). Polyphenols 53-64 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 49-52 9255589-10 1997 They are most likely related to the biochemical actions of the tea polyphenols, which include antioxidative activities and inhibition of cell proliferation and of tumor promotion-related activities. Polyphenols 67-78 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 63-66 9255589-12 1997 The bioavailability and pharmacokinetics of tea polyphenols are being studied in animals and humans to provide a basis for more quantitative analyses on the effect of tea on carcinogenesis. Polyphenols 48-59 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 44-47 9591194-3 1997 This article summarizes experimental data on chemopreventive effects of tea polyphenols in different tumor bioassay systems. Polyphenols 76-87 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 72-75 9591194-9 1997 Several epicatechin derivatives (polyphenols) present in green tea have been shown to possess anticarcinogenic activity; the most active is (-)-epigallocatechin-3-gallate, which is also the major constituent of GTP. Polyphenols 33-44 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 63-66 9591194-12 1997 These properties of tea polyphenols make them effective chemopreventive agents against the initiation, promotion, and progression stages of multistage carcinogenesis. Polyphenols 24-35 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 20-23 11051231-0 2000 Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA. Polyphenols 10-20 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 11051231-1 2000 Cancer chemopreventive effects of polyphenols from green tea (GTP) in mouse models of photocarcinogenesis are established. Polyphenols 34-45 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 57-60 10786933-0 2000 Cancer chemoprevention by tea polyphenols. Polyphenols 30-41 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 26-29 10786933-3 2000 The inhibitory effects of tea against carcinogenesis have been attributed to the biologic activities of the polyphenol fraction in tea. Polyphenols 108-118 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 26-29 10786933-3 2000 The inhibitory effects of tea against carcinogenesis have been attributed to the biologic activities of the polyphenol fraction in tea. Polyphenols 108-118 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 131-134 10786933-4 2000 This review summarizes experimental data on chemopreventive effects of tea polyphenols in various tumor bioassay systems. Polyphenols 75-86 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 71-74 10786933-5 2000 Many laboratory studies have demonstrated the inhibitory effects of green tea polyphenols, especially (-)-epigallocatechin-3-gallate (EGCG), on carcinogenesis in animals models. Polyphenols 78-89 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 74-77 10786933-6 2000 The majority of these studies have been conducted in mouse skin tumor models, where tea polyphenols were used either as oral feeding in drinking water or in direct local application. Polyphenols 88-99 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 84-87 10786933-7 2000 Most studies used 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet (UV) radiation as the tumor promoter and found anticarcinogenic effects caused by green tea polyphenols. Polyphenols 168-179 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 164-167 10786933-11 2000 The molecular mechanisms of the cancer chemopreventive effects of tea polyphenols are not completely understood. Polyphenols 70-81 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 66-69 10786933-12 2000 They are most likely related to the mechanisms of biochemical actions of tea polyphenols, which include antioxidative activities, modulation of xenobiotic metabolite enzymes and inhibition of tumor promotion. Polyphenols 77-88 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 73-76 10786933-13 2000 In addition, we have also proposed that tea polyphenols function as cancer chemopreventive agents through modulation of mitotic signal transduction. Polyphenols 44-55 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 40-43 1614996-2 1992 Since tea contains several polyphenols and since several other naturally occurring dietary polyphenols have shown antimutagenic effects in bacteria and anticarcinogenic effects in animal bioassay systems, we studied whether polyphenols extracted from Chinese green tea (GTP) also possess antimutagenic and anticarcinogenic effects. Polyphenols 27-38 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 8697942-0 1995 [Inhibition of colorectal carcinoma induced by 1, 2-dimethylhydrazine in mice with tea polyphenols]. Polyphenols 87-98 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 83-86