PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11054644-0 2000 Dose-response effects of a new growth hormone receptor antagonist (B2036-PEG) on circulating, hepatic and renal expression of the growth hormone/insulin-like growth factor system in adult mice. pegvisomant 67-76 growth hormone Mus musculus 31-45 16541323-2 2006 In this study we investigated the effect of a GH antagonist, pegvisomant (Somavert, Pfizer), on normal mammary gland development and breast cancer xenograft growth. pegvisomant 61-72 growth hormone Mus musculus 46-48 16541323-5 2006 This effect of pegvisomant was mediated by a complete inhibition of both GH and IGF-IR-mediated signaling within the gland. pegvisomant 15-26 growth hormone Mus musculus 73-75 24035867-5 2014 Since the GH/IGF-1 axis has been implicated in the progression of several types of cancers, many have suggested the use of pegvisomant as an anti-cancer therapeutic. pegvisomant 123-134 growth hormone Mus musculus 10-12