PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26470595-0 2015 Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio. deoxypodophyllotoxin 0-20 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 110-114 26470595-5 2015 In the current study, we found that DPT promotes cytoskeleton remodeling in human umbilical vein endothelial cells (HUVECs) via stimulation of AMP-activated protein kinase (AMPK) and that this effect is abolished by either treatment with a selective AMPK inhibitor or knockdown. deoxypodophyllotoxin 36-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 143-171 26470595-5 2015 In the current study, we found that DPT promotes cytoskeleton remodeling in human umbilical vein endothelial cells (HUVECs) via stimulation of AMP-activated protein kinase (AMPK) and that this effect is abolished by either treatment with a selective AMPK inhibitor or knockdown. deoxypodophyllotoxin 36-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 173-177 26470595-5 2015 In the current study, we found that DPT promotes cytoskeleton remodeling in human umbilical vein endothelial cells (HUVECs) via stimulation of AMP-activated protein kinase (AMPK) and that this effect is abolished by either treatment with a selective AMPK inhibitor or knockdown. deoxypodophyllotoxin 36-39 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 250-254 26470595-6 2015 Moreover, the cellular levels of LKB1, a kinase upstream of AMPK, were enhanced following DPT exposure. deoxypodophyllotoxin 90-93 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 60-64 26470595-7 2015 DPT-induced activation of AMPK in tumor vasculature effect was also verified by transgenic zebrafish (VEGFR2:GFP), Matrigel plug assay, and xenograft model in nude mice. deoxypodophyllotoxin 0-3 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 26-30