PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28299982-1 2017 We developed stimuli-labile polyrotaxanes (PRXs) composed of beta-cyclodextrin (beta-CD), Pluronic as an axle polymer, and acid-cleavable N-triphenylmethyl groups as bulky stopper molecules, and found that the PRXs are potent therapeutics for Niemann-Pick type C disease, because the PRX can effectively reduce intracellular cholesterol through the intracellular release of threaded beta-CDs. Rotaxanes 28-41 periaxin Mus musculus 43-46 25810046-3 2015 Herein, we report the sulfonated polyrotaxanes (S-PRX) composed of alpha-cyclodextrin threaded onto a linear polymer for the protection of BMP-2 through the polyelectrolyte complex formation. Rotaxanes 33-46 periaxin Mus musculus 50-53