PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18795249-13	2009	The dichotomous effects of isotretinoin are at least in part due to time- and dose-dependent alterations of transforming growth factor beta1 and collagen IV gene expression as also suggested by cell-culture studies in vascular smooth muscle cells.	Isotretinoin	27-39	transforming growth factor, beta 1	Rattus norvegicus	108-140	
11675406-3	2001	Therefore, the effects of all-trans retinoic acid and isotretinoin on the components of the TGF-beta system and extracellular matrix proteins in anti-Thy1.1-nephritis (Thy-GN) were investigated.	Isotretinoin	54-66	transforming growth factor, beta 1	Rattus norvegicus	92-100	
11675406-6	2001	The increase of cortical TGF-beta 1 gene expression in Thy-GN rats was significantly attenuated with all-trans retinoic acid and even more with isotretinoin treatment as compared with untreated animals (P < 0.025).	Isotretinoin	144-156	transforming growth factor, beta 1	Rattus norvegicus	25-35	
11737596-10	2001	The increase of transforming growth factor (TGF)-beta1, TGF receptor II and prepro-endothelin-1 gene expression in vehicle-treated nephritic rats was significantly attenuated by isotretinoin.	Isotretinoin	178-190	transforming growth factor, beta 1	Rattus norvegicus	16-54