PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17512311-0	2007	13-cis-Retinoic acid therapy induces insulin resistance, regulates inflammatory parameters, and paradoxically increases serum adiponectin concentration.	Isotretinoin	0-20	insulin	Homo sapiens	37-44	
18194936-7	2007	CONCLUSION: 13-cis-Retinoic acid likely causes insulin resistance through its role as an agonist of retinoid A and X receptors.	Isotretinoin	12-32	insulin	Homo sapiens	47-54	
18194936-8	2007	Although elevated levels of serum triglycerides are well documented with use of this drug, to the best of our knowledge this is the first report of a patient in whom polycystic ovary syndrome, a condition known to be associated with insulin resistance, manifested during isotretinoin therapy.	Isotretinoin	271-283	insulin	Homo sapiens	233-240	
17512311-1	2007	13-cis-Retinoic acid treatment causes insulin resistance and disturbances in lipid and glucose metabolism.	Isotretinoin	0-20	insulin	Homo sapiens	38-45	
11747145-0	2001	Dyslipidemia and a reversible decrease in insulin sensitivity induced by therapy with 13-cis-retinoic acid.	Isotretinoin	86-106	insulin	Homo sapiens	42-49	
16380803-1	2006	AIMS/HYPOTHESIS: We previously reported that treatment of acne with 13-cis-retinoic acid causes insulin resistance and disturbances in lipid metabolism resembling those of the insulin-resistance syndrome.	Isotretinoin	68-88	insulin	Homo sapiens	96-103	
16380803-5	2006	RESULTS: There was a reversible reduction in whole-body insulin sensitivity during therapy with 13-cis-retinoic acid.	Isotretinoin	96-116	insulin	Homo sapiens	56-63	
16380803-9	2006	CONCLUSIONS/INTERPRETATION: There is a paradoxical increase in fasting serum adiponectin concentration during the 13-cis-retinoic acid-induced reduction in insulin sensitivity.	Isotretinoin	114-134	insulin	Homo sapiens	156-163	
11747145-8	2001	CONCLUSION: Treatment of acne with 13-cis-retinoic acid reduces insulin sensitivity and induces alterations in lipid metabolism resembling those of the insulin resistance syndrome.	Isotretinoin	35-55	insulin	Homo sapiens	64-71	
32391951-2	2020	We therefore aimed to examine the effects of isotretinoin treatment on changes in insulin resistance and serum levels of adiponectin in patients with acne.	Isotretinoin	45-57	insulin	Homo sapiens	82-89	
31080813-8	2019	Results: Isotretinoin treatment significantly decreased Ferriman-Gallwey score, free testosterone, insulin level, hemoglobin level, acne score, and ovarian volume.	Isotretinoin	9-21	insulin	Homo sapiens	99-106	
31080813-10	2019	Conclusion: Isotretinoin treatment may have beneficial effects on free testosterone, insulin, acne score, and Ferriman-Gallwey score.	Isotretinoin	12-24	insulin	Homo sapiens	85-92	
30761880-6	2019	Conclusions: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in in-sulin resistance is not dependent on age, BMI, BFM, and lipid levels of these patients.	Isotretinoin	51-63	insulin	Homo sapiens	94-101	
30761880-1	2019	The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels.	Isotretinoin	137-149	insulin	Homo sapiens	153-160	
25573071-1	2015	BACKGROUND: The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting.	Isotretinoin	26-38	insulin	Homo sapiens	63-70