PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19331204-2 2009 The primary endpoint evaluated in this study was whether interleukin-2 (IL-2) and 13-cisretinoic acid (RA) treatment reduced VEGF and improved immune function in such patients. Isotretinoin 82-101 interleukin 2 receptor subunit alpha Homo sapiens 103-105 16767920-2 2003 We have demonstrated, in a phase IB study, that administering low-dose interleukin-2 (IL-2) and 13-cis retinoic acid (RA), there was a significant improvement of the immune function, with low toxicity, in PTS with advanced tumors that had been treated with aggressive surgery and chemotherapy (Clin Cancer Res 7: 1251-1257, 2001). Isotretinoin 96-116 interleukin 2 receptor subunit alpha Homo sapiens 118-120 12012010-2 2002 13-cis retinoic acid (RA) has immunomodulatory properties, potentially synergistic with IL-2. Isotretinoin 0-20 interleukin 2 receptor subunit alpha Homo sapiens 22-24 9067580-2 1997 Incubation of these cells for 48 h with either 13-cis retinoid acid (13-cis RA) or all-trans retinoic acid (ATRA) resulted in marked inhibition of cell growth, determined by 3H-thymidine incorporation, and in down-regulation of CD25 expression, determined by flow cytometry. Isotretinoin 69-78 interleukin 2 receptor subunit alpha Homo sapiens 228-232 8952316-1 1996 We observed the effects of the retinoic acid (13-cis retinoic acid; 13-cis RA, and all-trans retinoic acid; ATRA) for the cell growth and the expression of CD 25 on peripheral blood mononuclear cells (PBMC) from 17 patients with adult T cell leukemia (ATL). Isotretinoin 46-66 interleukin 2 receptor subunit alpha Homo sapiens 156-161