PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17512125-6	2007	Since the photochemistry of melanopsin is very similar to other opsin photopigments, and it is known that melanopsin uses the same retinaldehyde chromophore, it is hypothesized here that isotretinoin may exert inhibitory effect on chromophore regeneration in ipRGCs similar to what is seen in rod and cone cells, thus enabling to alter circadian and circannual rhythms.	Isotretinoin	187-199	opsin 4	Homo sapiens	28-38	
17512125-6	2007	Since the photochemistry of melanopsin is very similar to other opsin photopigments, and it is known that melanopsin uses the same retinaldehyde chromophore, it is hypothesized here that isotretinoin may exert inhibitory effect on chromophore regeneration in ipRGCs similar to what is seen in rod and cone cells, thus enabling to alter circadian and circannual rhythms.	Isotretinoin	187-199	opsin 4	Homo sapiens	106-116