PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31498706-3	2021	Objective: The purpose of this study was to assess the management and clinical outcome of acne patients with abnormal aspartate transaminase (AST) and alanine aminotransferase (ALT) when receiving isotretinoin.	Isotretinoin	197-209	solute carrier family 17 member 5	Homo sapiens	118-140	
34992430-10	2021	Results: Six month administration of oral isotretinoin in Egyptian AV patients is associated with significantly elevated aspartate transaminase (AST) in CC and AC genotypes (P<0.001).	Isotretinoin	42-54	solute carrier family 17 member 5	Homo sapiens	121-143	
34992430-10	2021	Results: Six month administration of oral isotretinoin in Egyptian AV patients is associated with significantly elevated aspartate transaminase (AST) in CC and AC genotypes (P<0.001).	Isotretinoin	42-54	solute carrier family 17 member 5	Homo sapiens	145-148	
34853752-17	2021	Conclusion The findings of this study indicate that oral isotretinoin can cause an elevation in ALT, AST, total cholesterol, and triglyceride levels but the incidence of these laboratory abnormalities is low and the elevation was not associated with significant morbidity, and therefore the practice of monthly laboratory monitoring for all patients while on isotretinoin needs to be revised as there is no strong evidence for such practice.	Isotretinoin	57-69	solute carrier family 17 member 5	Homo sapiens	101-104	
31498706-3	2021	Objective: The purpose of this study was to assess the management and clinical outcome of acne patients with abnormal aspartate transaminase (AST) and alanine aminotransferase (ALT) when receiving isotretinoin.	Isotretinoin	197-209	solute carrier family 17 member 5	Homo sapiens	142-145	
22714752-2	2012	OBJECTIVE: The objective of this study was to evaluate the profile of changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride levels in patients who had been treated with oral isotretinoin dispensed by the Sao Mateus/ES pharmacy for special drugs.	Isotretinoin	213-225	solute carrier family 17 member 5	Homo sapiens	113-139	
28686773-7	2017	75% report stopping isotretinoin when AST or ALT values reach 3 times normal; 89% report stopping at 4 times normal.	Isotretinoin	20-32	solute carrier family 17 member 5	Homo sapiens	38-41	
22714752-8	2012	After treatment with oral isotretinoin, triglyceride levels had increased beyond the normal range in 11% of the patients, while 8.6% had elevated AST levels and 7.3% had increased ALT levels.	Isotretinoin	26-38	solute carrier family 17 member 5	Homo sapiens	146-149	
22714752-9	2012	CONCLUSION: The results in this population show that the use of oral isotretinoin for the treatment of acne may result in altered triglyceride, AST and ALT levels.	Isotretinoin	69-81	solute carrier family 17 member 5	Homo sapiens	144-147