PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32391951-2	2020	We therefore aimed to examine the effects of isotretinoin treatment on changes in insulin resistance and serum levels of adiponectin in patients with acne.	Isotretinoin	45-57	adiponectin, C1Q and collagen domain containing	Homo sapiens	121-132	
32391951-8	2020	Our study concluded that isotretinoin treatment for patients with acne resulted in an increased serum level of adiponectin but did not have a substantial impact on the status of insulin resistance.	Isotretinoin	25-37	adiponectin, C1Q and collagen domain containing	Homo sapiens	111-122	
32411191-0	2020	The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.	Isotretinoin	88-100	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35	
32411191-4	2020	Aim: In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (n = 230).	Isotretinoin	158-170	adiponectin, C1Q and collagen domain containing	Homo sapiens	89-100	
32411191-10	2020	Conclusions: Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.	Isotretinoin	159-171	adiponectin, C1Q and collagen domain containing	Homo sapiens	59-65	
16380803-9	2006	CONCLUSIONS/INTERPRETATION: There is a paradoxical increase in fasting serum adiponectin concentration during the 13-cis-retinoic acid-induced reduction in insulin sensitivity.	Isotretinoin	114-134	adiponectin, C1Q and collagen domain containing	Homo sapiens	77-88	
27605902-7	2016	In addition, serum adiponectin and leptin levels were significantly increased following isotretinoin therapy while serum ghrelin levels were not different.	Isotretinoin	88-100	adiponectin, C1Q and collagen domain containing	Homo sapiens	19-30	
27605902-8	2016	CONCLUSIONS: Isotretinoin may exert its anti-inflammatory activity by increasing leptin and adiponectin levels.	Isotretinoin	13-25	adiponectin, C1Q and collagen domain containing	Homo sapiens	92-103	
17512311-0	2007	13-cis-Retinoic acid therapy induces insulin resistance, regulates inflammatory parameters, and paradoxically increases serum adiponectin concentration.	Isotretinoin	0-20	adiponectin, C1Q and collagen domain containing	Homo sapiens	126-137	
17512311-2	2007	We studied how 13-cis-retinoic acid affects inflammatory factors and adiponectin.	Isotretinoin	15-35	adiponectin, C1Q and collagen domain containing	Homo sapiens	69-80	
17512311-6	2007	Treatment with 13-cis-retinoic acid resulted in a significantly elevated serum adiponectin concentration (from 24.9 +/- 2.5 to 29.4 +/- 3.6 mg/L, P < .05), hemoglobin A(1c) (from 5.27% +/- 0.05% to 5.42% +/- 0.06%, P < .01), C-peptide area under the curve (from 314.2 +/- 16.6 to 350.0 +/- 21.0 (nmol .	Isotretinoin	15-35	adiponectin, C1Q and collagen domain containing	Homo sapiens	79-90	
17512311-8	2007	The increase in adiponectin during 13-cis-retinoic acid therapy correlated with baseline triglycerides (r = 0.51, P < .02).	Isotretinoin	35-55	adiponectin, C1Q and collagen domain containing	Homo sapiens	16-27	
29190629-0	2017	Suppressed Adiponectin Levels and Increased Adiponectin Response to Oral Glucose Load in Lean Women with Severe Acne Normalizes after Isotretinoin Treatment.	Isotretinoin	134-146	adiponectin, C1Q and collagen domain containing	Homo sapiens	44-55	
29190629-3	2017	In this study, we aimed to investigate adiponectin levels in postadolescent severe acne and the effect of isotretinoin on adiponectin levels.	Isotretinoin	106-118	adiponectin, C1Q and collagen domain containing	Homo sapiens	122-133	
29190629-8	2017	Isotretinoin treatment resulted in a significant increase in weight, BMI, and triglyceride and adiponectin levels.	Isotretinoin	0-12	adiponectin, C1Q and collagen domain containing	Homo sapiens	95-106	
29190629-11	2017	Remarkably, this OGTT-induced adiponectin increment in acne patients was diminished after isotretinoin treatment.	Isotretinoin	90-102	adiponectin, C1Q and collagen domain containing	Homo sapiens	30-41	
29190629-13	2017	Suppression of baseline adiponectin ameliorates after 6 months of isotretinoin treatment, reaching levels similar to those of healthy controls.	Isotretinoin	66-78	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35	
25573071-8	2015	CONCLUSION: ISO may affect leptin and adiponectin levels.	Isotretinoin	12-15	adiponectin, C1Q and collagen domain containing	Homo sapiens	38-49