PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20726329-4	2009	This work aimed to study the degree of expression of TLR2 on peripheral blood monocytes (PBM) from patients with non-inflammatory and inflammatory acne and to investigate the influence of systemic isotretinoin therapy on TLR2 expression.	Isotretinoin	197-209	toll like receptor 2	Homo sapiens	221-225	
22513780-0	2012	Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients.	Isotretinoin	9-21	toll like receptor 2	Homo sapiens	53-58	
22513780-5	2012	Treatment of patients with isotretinoin significantly decreased monocyte TLR-2 expression and subsequent inflammatory cytokine response to P. acnes after 1 week of therapy.	Isotretinoin	27-39	toll like receptor 2	Homo sapiens	73-78	
22513780-6	2012	This effect was sustained 6 months following cessation of therapy, indicating that TLR-2 modulation may be involved in the durable therapeutic response to isotretinoin.	Isotretinoin	155-167	toll like receptor 2	Homo sapiens	83-88