PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28554658-4 2017 However, recent studies demonstrate Cr(VI) inhibits homologous recombination repair through the misregulation of RAD51. chromium hexavalent ion 36-42 RAD51 recombinase Homo sapiens 113-118 28554658-6 2017 Recent studies show prolonged Cr(VI) exposure prevents proper RAD51 subcellular localization, causing it to accumulate in the cytoplasm. chromium hexavalent ion 30-36 RAD51 recombinase Homo sapiens 62-67 28554658-10 2017 These results correlate temporally with the previously reported Cr(VI)-induced RAD51 cytoplasmic accumulation. chromium hexavalent ion 64-70 RAD51 recombinase Homo sapiens 79-84 27449664-9 2016 The response of proteins involved in Rad51 nuclear import and nucleofilament formation displayed varying responses to prolonged Cr(VI) exposure. chromium hexavalent ion 128-134 RAD51 recombinase Homo sapiens 37-42 33677506-4 2021 Particulate Cr(VI) causes DNA double strand breaks and prolonged exposure impairs homologous recombination targeting a key effector protein in this pathway, RAD51. chromium hexavalent ion 12-18 RAD51 recombinase Homo sapiens 157-162 33677506-5 2021 Reduced RAD51 protein is a key endpoint of particulate Cr(VI) exposure. chromium hexavalent ion 55-61 RAD51 recombinase Homo sapiens 8-13 33677506-6 2021 It is currently unknown how Cr(VI) reduces RAD51 protein. chromium hexavalent ion 28-34 RAD51 recombinase Homo sapiens 43-48 33677506-8 2021 This study sought to identify if E2F1 modulates the RAD51 response to particulate Cr(VI). chromium hexavalent ion 82-88 RAD51 recombinase Homo sapiens 52-57 33677506-9 2021 Particulate Cr(VI) reduced RAD51 protein and mRNA levels but had a minimal effect on RAD51 half-life. chromium hexavalent ion 12-18 RAD51 recombinase Homo sapiens 27-32 33677506-12 2021 E2F1 knockdown inhibited RAD51 nuclear foci formation after acute particulate Cr(VI) exposure. chromium hexavalent ion 78-84 RAD51 recombinase Homo sapiens 25-30 33677506-13 2021 These data indicate reduced RAD51 protein levels after prolonged particulate Cr(VI) exposure are predominantly due to inhibited expression. chromium hexavalent ion 77-83 RAD51 recombinase Homo sapiens 28-33