PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30397150-4 2018 This hyperplastic/inflammatory prostate has a human prostate cancer-like microRNA profile, with up-regulation of the Zn-homeostasis-regulating miR-183-96-182 cluster (fold change = 1.41-2.38; P = 0.029-0.0003) and down-regulation of the Zn importer ZIP1 (target of miR-182), leading to a reduction of prostatic Zn. Zinc 117-119 solute carrier family 39 member 1 Homo sapiens 249-253 11301334-4 2001 First, we examined (65)Zn uptake activity in K562 erythroleukemia cells overexpressing hZIP1. Zinc 23-25 solute carrier family 39 member 1 Homo sapiens 87-92 11301334-9 2001 Furthermore, hZIP1-dependent (65)Zn uptake was biochemically indistinguishable from the endogenous activity. Zinc 33-35 solute carrier family 39 member 1 Homo sapiens 13-18 11301334-10 2001 Finally, inhibition of endogenous hZIP1 expression with antisense oligonucleotides caused a marked decrease in endogenous (65)Zn uptake activity. Zinc 126-128 solute carrier family 39 member 1 Homo sapiens 34-39 16183033-7 2005 The IC50 for proton effects was close to the pKa for histidine, suggesting conserved histidine residues present in SLC39A1 play a critical role in Zn2+ influx and are involved in the pH effect. Zinc 147-151 solute carrier family 39 member 1 Homo sapiens 115-122 30581142-3 2019 Here, we found that MMP is reduced focally at a fission site by the Drp1 recruitment, which is initiated by the interaction of Drp1 with mitochondrial zinc transporter Zip1 and Zn2+ entry through the Zip1-MCU complex. Zinc 177-181 solute carrier family 39 member 1 Homo sapiens 200-204 30397150-5 2018 This inverse relationship between miR-182 and ZIP1 also occurs in human prostate cancer tissue, which is known for Zn loss. Zinc 115-117 solute carrier family 39 member 1 Homo sapiens 46-50 30397150-6 2018 The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid (P = 0.0003), links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR-183-96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer. Zinc 23-25 solute carrier family 39 member 1 Homo sapiens 344-348 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 16-20 solute carrier family 39 member 1 Homo sapiens 93-97 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 16-20 solute carrier family 39 member 1 Homo sapiens 167-171 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 93-97 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 167-171 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 93-97 29721422-4 2018 Moreover, zinc (Zn2+) is identified playing dual functions: (i) Zn2+ influx is influenced by ZIP1 which is regulated by Runx2 and Osterix to form a zinc-Runx2/Osterix-ZIP1 regulation axis promoting osteogenic differentiation; (ii) Zn2+ enhances citrate accumulation and deposition in bone apatite. Zinc 64-68 solute carrier family 39 member 1 Homo sapiens 167-171 23378263-9 2013 Functional studies to establish a role for hZip1 in cellular zinc accumulation were carried out using (65)Zn. Zinc 106-108 solute carrier family 39 member 1 Homo sapiens 43-48 25162517-4 2014 In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in response to Zn treatment, including the metal binding protein MT-1, the zinc efflux protein ZnT-1, and the zinc influx regulator ZIP-1. Zinc 147-149 solute carrier family 39 member 1 Homo sapiens 264-269 25755079-8 2015 Both MT1A and ZIP1 expression showed a significant increase in the Zn supplemented group (p < 0.05). Zinc 67-69 solute carrier family 39 member 1 Homo sapiens 14-18 23064315-4 2012 The aim of this study was to determine the expression levels of selected miRNA and zinc(II)-related genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II) treatment. Zinc 95-103 solute carrier family 39 member 1 Homo sapiens 131-136 23064315-4 2012 The aim of this study was to determine the expression levels of selected miRNA and zinc(II)-related genes (ZIP-1, BAX, MT2A and MT1A) in the non-tumor PNT1A prostate cell line in comparison with the prostate cancer cell lines 22Rv1, PC-3 and LNCaP after zinc(II) treatment. Zinc 290-298 solute carrier family 39 member 1 Homo sapiens 131-136 22570624-4 2012 Using a genetically tractable Drosophila model, we found that the expression of dZip1, the orthologue of human Slc39 family transporter hZip1 in Drosophila, was altered in the brains of Abeta42-expressing flies, and Zn homeostasis could be modulated by forcible dZip1 expression changes. Zinc 216-218 solute carrier family 39 member 1 Homo sapiens 136-141 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Zinc 227-229 solute carrier family 39 member 1 Homo sapiens 36-41 22253048-6 2011 Expression of Zrt-Irt-like protein (ZIP)1, a plasma membrane-type zinc transporter, was detected in microglia, and nickel, a relatively sensitive substrate/inhibitor of ZIP1, showed cis- and trans-inhibitory effects on the (65)Zn uptake. Zinc 227-229 solute carrier family 39 member 1 Homo sapiens 169-173 20705137-7 2010 Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method. Zinc 51-53 solute carrier family 39 member 1 Homo sapiens 187-192 20705137-7 2010 Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method. Zinc 171-173 solute carrier family 39 member 1 Homo sapiens 187-192 20705137-7 2010 Here we report a new method to show a differential Zn staining method that correlates with various stages of prostate cancer development in situ and expression of a human Zn transporter1-hZIP1 -in situ by in situ reverse transcriptase-polymerase chain reaction hybridization (ISRTPCR) that correlate with the relative Zn levels determined by the differential Zn staining method. Zinc 171-173 solute carrier family 39 member 1 Homo sapiens 187-192