PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12593667-1 2003 Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. Zinc 185-187 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 28-33 12606709-3 2003 This alteration is hypothesized to cause neurodegeneration by permitting a lethal influx of Ca(2+) and/or Zn(2+) through newly formed GluR2-lacking AMPA receptors. Zinc 106-108 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 134-139 33046551-1 2020 Zn2+ has been shown to have a wide range of modulatory effects on neuronal AMPARs. Zinc 0-4 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 75-81 33046551-3 2020 Here we show that Zn2+ inhibits GluA2(Q) homomeric receptors in an activity- and voltage-dependent manner, indicating a pore block mechanism. Zinc 18-22 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 32-37 33046551-9 2020 Here we have systematically studied Zn2+ inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn2+ inhibits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the receptors. Zinc 36-40 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 55-61 33046551-9 2020 Here we have systematically studied Zn2+ inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn2+ inhibits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the receptors. Zinc 151-155 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 55-61 33046551-9 2020 Here we have systematically studied Zn2+ inhibition of AMPARs by varying calcium permeability, auxiliary subunits, and activation levels and show that Zn2+ inhibits AMPARs in an activity-dependent manner, opening up this pathway as a means to pharmacologically modulate the receptors. Zinc 151-155 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 165-171 17114218-9 2007 Binding of the polyamines and Zn(II) to the S1S2 domain of the GluR2 subunit was not observed. Zinc 30-36 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 63-68 17275103-2 2007 AMPA receptors lacking GluR2 subunits are permeable to Ca(2+) and Zn(2+). Zinc 66-68 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 23-28 16215279-5 2005 Circumstance data have indicated that the GluR2 subunits dictate Ca2+/Zn2+ permeability of AMPA receptor channels and gate injurious Ca2+/Zn2+ signals in vulnerable neurons. Zinc 70-74 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 42-47 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 212-214 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 108-114 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 212-214 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 230-244 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 212-214 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 246-251 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 212-214 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 261-267 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 287-289 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 108-114 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 287-289 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 230-244 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 287-289 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 246-251 16093311-3 2005 Here we show that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) at Schaffer collateral to CA1 synapses in postischemic hippocampus exhibit properties of Ca(2+)/Zn(2+)-permeable, Glu receptor 2 (GluR2)-lacking AMPARs before the rise in Zn(2+) and cell death. Zinc 287-289 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 261-267 16093311-7 2005 These results implicate GluR2-lacking AMPA receptors in the ischemia-induced rise in free Zn(2+) and death of CA1 neurons, although a direct action at the time of the rise in Zn(2+) is unproven. Zinc 90-92 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 24-29 16093311-7 2005 These results implicate GluR2-lacking AMPA receptors in the ischemia-induced rise in free Zn(2+) and death of CA1 neurons, although a direct action at the time of the rise in Zn(2+) is unproven. Zinc 175-177 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 24-29 15525775-1 2004 Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons. Zinc 66-70 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 98-118 15525775-1 2004 Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons. Zinc 66-70 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 120-125 15525775-1 2004 Transient global ischemia induces a delayed rise in intracellular Zn2+, which may be mediated via glutamate receptor 2 (GluR2)-lacking AMPA receptors (AMPARs), and selective, delayed death of hippocampal CA1 neurons. Zinc 66-70 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 151-157 15525775-5 2004 Early CaEDTA attenuated ischemia-induced GluR2 mRNA and protein downregulation (and, by inference, formation of Zn2+-permeable AMPARs), the delayed rise in Zn2+, and neuronal death. Zinc 112-116 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 127-133 15525775-6 2004 These findings suggest that Zn2+ acts at step(s) upstream from GluR2 gene downregulation and implicate Zn2+ in transcriptional regulation and/or GluR2 mRNA stability. Zinc 28-32 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 63-68