PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26934981-2 2016 The PIKfyve complex, consisting of the phosphoinositide kinase PIKfyve (also known as FAB1), VAC14 and FIG4, is required for the production of phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2]. phosphatidylinositol 3,5-diphosphate 143-180 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 86-90 29674454-2 2018 On the surface of lysosomes, the PIKfyve/Fab1 complex generates phosphatidylinositol 3,5-bisphosphate, PI-3,5-P2, which is critical for lysosomal membrane homeostasis during acute osmotic stress and for lysosomal signaling. phosphatidylinositol 3,5-diphosphate 64-101 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 41-45 29674454-2 2018 On the surface of lysosomes, the PIKfyve/Fab1 complex generates phosphatidylinositol 3,5-bisphosphate, PI-3,5-P2, which is critical for lysosomal membrane homeostasis during acute osmotic stress and for lysosomal signaling. phosphatidylinositol 3,5-diphosphate 103-112 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 41-45 29674454-3 2018 Here, we identify the inverted BAR protein Ivy1 as an inhibitor of the Fab1 complex with a direct influence on PI-3,5-P2 levels and vacuole homeostasis. phosphatidylinositol 3,5-diphosphate 111-120 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 71-75 28148651-0 2017 An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels. phosphatidylinositol 3,5-diphosphate 78-115 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 54-58 28148651-3 2017 PI(3,5)P2 is generated from PI3P by the conserved lipid kinase Fab1/PIKfyve. phosphatidylinositol 3,5-diphosphate 0-9 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 63-67 28148651-8 2017 We also identify mutations in the CCR domain that lead to elevated levels of PI(3,5)P2 Together these findings reveal a regulatory mechanism that involves the CCR domain of Fab1 and contributes to dynamic control of cellular PI(3,5)P2 synthesis. phosphatidylinositol 3,5-diphosphate 77-86 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 173-177 28148651-8 2017 We also identify mutations in the CCR domain that lead to elevated levels of PI(3,5)P2 Together these findings reveal a regulatory mechanism that involves the CCR domain of Fab1 and contributes to dynamic control of cellular PI(3,5)P2 synthesis. phosphatidylinositol 3,5-diphosphate 225-234 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 173-177 26934981-2 2016 The PIKfyve complex, consisting of the phosphoinositide kinase PIKfyve (also known as FAB1), VAC14 and FIG4, is required for the production of phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2]. phosphatidylinositol 3,5-diphosphate 182-191 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 86-90 26216398-3 2016 PI(3,5)P2 is formed by phosphorylation of PI(3)P by the PIKfyve complex which is crucial for maintaining endosomal homeostasis. phosphatidylinositol 3,5-diphosphate 0-9 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 56-63 26862203-3 2016 A large complex of proteins that includes the lipid kinase Fab1-PIKfyve, dynamically regulates the levels of PI(3,5)P2. phosphatidylinositol 3,5-diphosphate 109-118 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 59-63 26216398-9 2016 We show that APP binding to the PIKfyve complex drives formation of PI(3,5)P2 positive vesicles and that APP gene family members are required for supporting PIKfyve function. phosphatidylinositol 3,5-diphosphate 68-77 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 32-39 26216398-10 2016 Interestingly, the PIKfyve complex is required for APP trafficking, suggesting a feedback loop in which APP, by binding to and stimulating PI(3,5)P2 vesicle formation may control its own trafficking. phosphatidylinositol 3,5-diphosphate 139-148 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 19-26 24323921-3 2014 A complex of proteins that includes Fab1/PIKfyve, Vac14, and Fig4/Sac3 mediates the biosynthesis of PI(3,5)P2 , and mutations that disrupt complex function and/or formation cause profound consequences in cells. phosphatidylinositol 3,5-diphosphate 100-109 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 36-40 25713145-6 2015 Fab1, along with its mammalian ortholog PIKfyve, is the lipid kinase responsible for synthesizing PtdIns(3,5)P2. phosphatidylinositol 3,5-diphosphate 98-111 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 0-4 20630877-1 2010 The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)) phosphatase Sac3 and ArPIKfyve, the associated regulator of the PtdIns3P-5 kinase PIKfyve, form a stable binary complex that associates with PIKfyve in a ternary complex to increase PtdIns(3,5)P(2) production. phosphatidylinositol 3,5-diphosphate 55-70 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 154-161 23389034-3 2013 The Fab1/PIKfyve lipid kinase phosphorylates PtdIns(3)P into PtdIns(3,5)P2 whereas the Fig4/Sac3 lipid phosphatase antagonizes this reaction. phosphatidylinositol 3,5-diphosphate 61-74 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 4-8 23389034-4 2013 Interestingly, Fab1 and Fig4 form a common protein complex that coordinates synthesis and degradation of PtdIns(3,5)P2 by a poorly understood process. phosphatidylinositol 3,5-diphosphate 105-118 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 15-19 23389034-5 2013 Assembly of the Fab1 complex requires Vac14/ArPIKfyve, a multimeric scaffolding adaptor protein that coordinates synthesis and turnover of PtdIns(3,5)P2. phosphatidylinositol 3,5-diphosphate 139-152 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 16-20 21736686-8 2012 PtdIns(3,5)P(2) synthesis and turnover are tightly coupled via a protein complex that includes the Fab1/PIKfyve lipid kinase and its antagonistic Fig4/Sac3 lipid phosphatase. phosphatidylinositol 3,5-diphosphate 0-15 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 100-104 20630877-1 2010 The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)) phosphatase Sac3 and ArPIKfyve, the associated regulator of the PtdIns3P-5 kinase PIKfyve, form a stable binary complex that associates with PIKfyve in a ternary complex to increase PtdIns(3,5)P(2) production. phosphatidylinositol 3,5-diphosphate 14-53 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 95-102 20630877-1 2010 The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)) phosphatase Sac3 and ArPIKfyve, the associated regulator of the PtdIns3P-5 kinase PIKfyve, form a stable binary complex that associates with PIKfyve in a ternary complex to increase PtdIns(3,5)P(2) production. phosphatidylinositol 3,5-diphosphate 14-53 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 154-161 20630877-1 2010 The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P(2)) phosphatase Sac3 and ArPIKfyve, the associated regulator of the PtdIns3P-5 kinase PIKfyve, form a stable binary complex that associates with PIKfyve in a ternary complex to increase PtdIns(3,5)P(2) production. phosphatidylinositol 3,5-diphosphate 55-70 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 95-102 9660759-10 1998 When expressed in mammalian cells, PIP5K Ialpha and PIP5K Ibeta differed in their ability to synthesize PtdIns-3,5-P2 relative to PtdIns-3,4-P2. phosphatidylinositol 3,5-diphosphate 104-117 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 35-40 16954148-1 2006 The yeast gene fab1 and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]. phosphatidylinositol 3,5-diphosphate 179-216 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 49-55 16954148-1 2006 The yeast gene fab1 and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]. phosphatidylinositol 3,5-diphosphate 179-216 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 123-128 16954148-1 2006 The yeast gene fab1 and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]. phosphatidylinositol 3,5-diphosphate 218-233 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 49-55 16954148-1 2006 The yeast gene fab1 and its mammalian orthologue Pip5k3 encode the phosphatidylinositol 3-phosphate [PtdIns(3)P] 5-kinases Fab1p and PIKfyve, respectively, enzymes that generates phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P(2)]. phosphatidylinositol 3,5-diphosphate 218-233 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 123-128 10567352-2 1999 In Saccharomyces cerevisiae, PtdIns(3,5)P(2) synthesis is catalyzed by the PtdIns3P 5-kinase Fab1p, and loss of this activity results in vacuolar morphological defects, indicating that PtdIns(3,5)P(2) is essential for vacuole homeostasis. phosphatidylinositol 3,5-diphosphate 29-44 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 93-98 17556371-3 2007 This is reinforced by the structural and functional homology of yeast Vac14 and human Vac14 (ArPIKfyve), which activate yeast and mammalian PtdIns(3,5)P2-producing enzymes, Fab1 and PIKfyve, respectively. phosphatidylinositol 3,5-diphosphate 140-153 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 173-177 15103325-1 2004 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), made by Fab1p, is essential for vesicle recycling from vacuole/lysosomal compartments and for protein sorting into multivesicular bodies. phosphatidylinositol 3,5-diphosphate 0-37 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 63-68 15103325-1 2004 Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), made by Fab1p, is essential for vesicle recycling from vacuole/lysosomal compartments and for protein sorting into multivesicular bodies. phosphatidylinositol 3,5-diphosphate 39-52 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 63-68 33157024-5 2021 Accordingly, TORC1 can phosphorylate Fab1 proximal to its PI3P-interacting FYVE domain, which causes Fab1 to shift to signaling endosomes, where it generates PI(3,5)P2. phosphatidylinositol 3,5-diphosphate 158-167 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 37-41 33157024-5 2021 Accordingly, TORC1 can phosphorylate Fab1 proximal to its PI3P-interacting FYVE domain, which causes Fab1 to shift to signaling endosomes, where it generates PI(3,5)P2. phosphatidylinositol 3,5-diphosphate 158-167 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 101-105 31628917-1 2019 Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. phosphatidylinositol 3,5-diphosphate 49-62 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 128-135