PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32256785-0 2020 Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression. hydroxysafflor yellow A 0-23 mitogen-activated protein kinase 1 Homo sapiens 97-100 27713966-0 2016 Hydroxysafflor yellow A inhibits IL-1beta-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-kappaB and AP-1 signaling in SW982 human synovial cells. hydroxysafflor yellow A 0-23 mitogen-activated protein kinase 1 Homo sapiens 102-105 31055884-0 2019 Hydroxysafflor yellow A inhibited lipopolysaccharide-induced non-small cell lung cancer cell proliferation, migration, and invasion by suppressing the PI3K/AKT/mTOR and ERK/MAPK signaling pathways. hydroxysafflor yellow A 0-23 mitogen-activated protein kinase 1 Homo sapiens 169-172 31055884-0 2019 Hydroxysafflor yellow A inhibited lipopolysaccharide-induced non-small cell lung cancer cell proliferation, migration, and invasion by suppressing the PI3K/AKT/mTOR and ERK/MAPK signaling pathways. hydroxysafflor yellow A 0-23 mitogen-activated protein kinase 1 Homo sapiens 173-177 27713966-5 2016 HSYA also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), p65 and c-Jun. hydroxysafflor yellow A 0-4 mitogen-activated protein kinase 1 Homo sapiens 43-80 27713966-5 2016 HSYA also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), p65 and c-Jun. hydroxysafflor yellow A 0-4 mitogen-activated protein kinase 1 Homo sapiens 82-85 27713966-7 2016 These results indicate that the inhibitory effects of HSYA on IL-1beta-induced IL-6, IL-8 and MMP-1 release might be mediated via suppression of ERK, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) signaling pathways. hydroxysafflor yellow A 54-58 mitogen-activated protein kinase 1 Homo sapiens 145-148