PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35380741-7 2022 Our data demonstrated an unreported role of PSMG3-AS1 in TMZ resistance and provide a potential novel target to tackle TMZ resistance in GBM. Temozolomide 119-122 proteasome assembly chaperone 3 Homo sapiens 44-49 35380741-0 2022 PSMG3-AS1 enhances glioma resistance to temozolomide via stabilizing c-Myc in the nucleus. Temozolomide 40-52 proteasome assembly chaperone 3 Homo sapiens 0-5 35380741-5 2022 We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. Temozolomide 70-73 proteasome assembly chaperone 3 Homo sapiens 26-31 35380741-5 2022 We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. Temozolomide 70-73 proteasome assembly chaperone 3 Homo sapiens 91-96 35380741-5 2022 We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. Temozolomide 235-238 proteasome assembly chaperone 3 Homo sapiens 26-31 35380741-5 2022 We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. Temozolomide 235-238 proteasome assembly chaperone 3 Homo sapiens 91-96 35380741-5 2022 We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. Temozolomide 235-238 proteasome assembly chaperone 3 Homo sapiens 164-169 35380741-6 2022 Mechanistically, PSMG3-AS1 directly binds to c-Myc and thus stabilizes c-Myc in the nucleus to promote the survival of GBM cells under treatment of TMZ. Temozolomide 148-151 proteasome assembly chaperone 3 Homo sapiens 17-22 35380741-7 2022 Our data demonstrated an unreported role of PSMG3-AS1 in TMZ resistance and provide a potential novel target to tackle TMZ resistance in GBM. Temozolomide 57-60 proteasome assembly chaperone 3 Homo sapiens 44-49